ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	179/1045	423/7206	2.98902251923e-47
ko04724	Glutamatergic synapse	82/1045	152/7206	1.01360230986e-30
ko04721	Synaptic vesicle cycle	55/1045	80/7206	2.04951494552e-28
ko05033	Nicotine addiction	44/1045	56/7206	5.51873233595e-27
ko04713	Circadian entrainment	67/1045	136/7206	2.61161176472e-22
ko04727	GABAergic synapse	59/1045	110/7206	3.41915041056e-22
ko05032	Morphine addiction	59/1045	110/7206	3.41915041056e-22
ko04728	Dopaminergic synapse	79/1045	185/7206	3.73906740664e-21
ko04725	Cholinergic synapse	71/1045	160/7206	2.91535681025e-20
ko04723	Retrograde endocannabinoid signaling	70/1045	175/7206	5.27198493852e-17
ko04024	cAMP signaling pathway	94/1045	279/7206	1.94183072085e-16
ko04911	Insulin secretion	52/1045	117/7206	3.51981986574e-15
ko04921	Oxytocin signaling pathway	74/1045	209/7206	1.90660138308e-14
ko04020	Calcium signaling pathway	87/1045	265/7206	1.92221655781e-14
ko04726	Serotonergic synapse	55/1045	137/7206	1.08847832212e-13
ko04742	Taste transduction	33/1045	61/7206	4.25914210602e-13
ko04261	Adrenergic signaling in cardiomyocytes	67/1045	205/7206	2.41686995449e-11
ko05031	Amphetamine addiction	38/1045	91/7206	1.87326578373e-10
ko04970	Salivary secretion	39/1045	95/7206	1.99327549852e-10
ko04720	Long-term potentiation	40/1045	99/7206	2.08382427571e-10
ko04966	Collecting duct acid secretion	17/1045	26/7206	4.20880509797e-09
ko03040	Spliceosome	1/1045	145/7206	5.78519314243e-09
ko04744	Phototransduction	20/1045	36/7206	1.02739078468e-08
ko05168	Herpes simplex infection	4/1045	182/7206	2.40399558824e-08
ko04971	Gastric acid secretion	35/1045	98/7206	1.17817689124e-07
ko05164	Influenza A	4/1045	167/7206	1.69131180522e-07
ko05203	Viral carcinogenesis	13/1045	277/7206	1.86924168564e-07
ko04925	Aldosterone synthesis and secretion	36/1045	105/7206	3.16047236329e-07
ko04060	Cytokine-cytokine receptor interaction	6/1045	191/7206	3.23518366153e-07
ko04360	Axon guidance	63/1045	233/7206	3.65432655279e-07
ko05030	Cocaine addiction	28/1045	73/7206	4.01396513546e-07
ko04740	Olfactory transduction	29/1045	80/7206	1.00075515081e-06
ko03013	RNA transport	5/1045	166/7206	1.07309007415e-06
ko04540	Gap junction	40/1045	128/7206	1.32999482184e-06
ko04120	Ubiquitin mediated proteolysis	3/1045	138/7206	1.88843171451e-06
ko04260	Cardiac muscle contraction	32/1045	98/7206	4.09804636064e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1045	74/7206	7.03038421465e-06
ko05110	Vibrio cholerae infection	23/1045	63/7206	1.14521952634e-05
ko04976	Bile secretion	27/1045	80/7206	1.44495273816e-05
ko04010	MAPK signaling pathway	74/1045	321/7206	3.04979486662e-05
ko04022	cGMP-PKG signaling pathway	54/1045	216/7206	3.23068118101e-05
ko04745	Phototransduction - fly	16/1045	38/7206	3.25164508243e-05
ko05322	Systemic lupus erythematosus	6/1045	151/7206	3.46377654632e-05
ko04514	Cell adhesion molecules (CAMs)	37/1045	130/7206	3.93850296338e-05
ko04730	Long-term depression	25/1045	78/7206	6.69839423467e-05
ko04924	Renin secretion	27/1045	86/7206	6.87155967626e-05
ko04621	NOD-like receptor signaling pathway	7/1045	157/7206	7.73841849696e-05
ko04964	Proximal tubule bicarbonate reclamation	13/1045	29/7206	8.21577937666e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1045	79/7206	8.28593158626e-05
ko04972	Pancreatic secretion	32/1045	111/7206	9.87899513361e-05
ko05162	Measles	4/1045	120/7206	0.000110248514302
ko05169	Epstein-Barr virus infection	12/1045	206/7206	0.000116740187112
ko04141	Protein processing in endoplasmic reticulum	10/1045	184/7206	0.000118613358423
ko04612	Antigen processing and presentation	1/1045	77/7206	0.000125505784379
ko03008	Ribosome biogenesis in eukaryotes	1/1045	79/7206	0.000136006340836
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1045	59/7206	0.000233734900097
ko04750	Inflammatory mediator regulation of TRP channels	33/1045	122/7206	0.000238410770001
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1045	14/7206	0.000253261031748
ko05414	Dilated cardiomyopathy	31/1045	112/7206	0.000337341445403
ko04014	Ras signaling pathway	62/1045	279/7206	0.000477791007227
ko04610	Complement and coagulation cascades	2/1045	79/7206	0.000633854973096
ko04915	Estrogen signaling pathway	33/1045	131/7206	0.00102517066804
ko04371	Apelin signaling pathway	42/1045	177/7206	0.00105642132029
ko04110	Cell cycle	8/1045	145/7206	0.00113032119637
ko05161	Hepatitis B	11/1045	173/7206	0.00137243770983
ko05140	Leishmaniasis	2/1045	75/7206	0.00138859947897
ko00240	Pyrimidine metabolism	5/1045	110/7206	0.00145691078957
ko04064	NF-kappa B signaling pathway	4/1045	96/7206	0.00189181036431
ko04214	Apoptosis - fly	2/1045	72/7206	0.00202473810568
ko00480	Glutathione metabolism	1/1045	55/7206	0.00325514899051
ko04668	TNF signaling pathway	7/1045	120/7206	0.00387348511752
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1045	92/7206	0.00401132763126
ko05166	HTLV-I infection	26/1045	292/7206	0.00492580548811
ko04978	Mineral absorption	13/1045	40/7206	0.00497620142812
ko04974	Protein digestion and absorption	24/1045	96/7206	0.00537830637304
ko05205	Proteoglycans in cancer	24/1045	271/7206	0.00620300888893
ko04640	Hematopoietic cell lineage	2/1045	64/7206	0.00639482944301
ko04140	Autophagy - animal	12/1045	164/7206	0.00673084082789
ko00310	Lysine degradation	3/1045	73/7206	0.0070079033366
ko04922	Glucagon signaling pathway	30/1045	128/7206	0.00722375308442
ko04217	Necroptosis	14/1045	178/7206	0.00932623583059
ko04626	Plant-pathogen interaction	7/1045	18/7206	0.0097511495374
ko04072	Phospholipase D signaling pathway	42/1045	197/7206	0.00988081967031
ko04350	TGF-beta signaling pathway	6/1045	103/7206	0.0103338348991
ko03420	Nucleotide excision repair	1/1045	46/7206	0.0107202614062
ko05321	Inflammatory bowel disease (IBD)	2/1045	56/7206	0.0130311471685
ko04146	Peroxisome	5/1045	89/7206	0.0143919591944
ko04015	Rap1 signaling pathway	55/1045	278/7206	0.0146644568244
ko04916	Melanogenesis	31/1045	142/7206	0.0158279502185
ko05144	Malaria	1/1045	45/7206	0.0167876297348
ko04210	Apoptosis	15/1045	180/7206	0.0177328717716
ko04912	GnRH signaling pathway	27/1045	122/7206	0.0195327193454
ko04657	IL-17 signaling pathway	5/1045	87/7206	0.0201238596987
ko01524	Platinum drug resistance	4/1045	76/7206	0.0203896892168
ko04923	Regulation of lipolysis in adipocytes	19/1045	77/7206	0.0209814782462
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1045	100/7206	0.0212072687773
ko00190	Oxidative phosphorylation	28/1045	127/7206	0.0212212646385
ko05323	Rheumatoid arthritis	21/1045	89/7206	0.021733571548
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1045	40/7206	0.0236125506578
ko04630	Jak-STAT signaling pathway	10/1045	132/7206	0.0237560110898
ko05131	Shigellosis	5/1045	82/7206	0.0265983138287
ko05212	Pancreatic cancer	5/1045	83/7206	0.0268382980464
ko03018	RNA degradation	5/1045	84/7206	0.0273942475948
ko05418	Fluid shear stress and atherosclerosis	15/1045	173/7206	0.0281678516181
ko04330	Notch signaling pathway	3/1045	62/7206	0.028198701426
ko04622	RIG-I-like receptor signaling pathway	3/1045	62/7206	0.028198701426
ko05215	Prostate cancer	8/1045	111/7206	0.0286376651219
ko04620	Toll-like receptor signaling pathway	7/1045	100/7206	0.0310737210563
ko05010	Alzheimer's disease	40/1045	202/7206	0.0333632858788
ko00982	Drug metabolism - cytochrome P450	1/1045	37/7206	0.0349556901607
ko04270	Vascular smooth muscle contraction	32/1045	154/7206	0.0362857854144
ko00260	Glycine, serine and threonine metabolism	2/1045	48/7206	0.0386876145357
ko05219	Bladder cancer	2/1045	48/7206	0.0386876145357
ko04218	Cellular senescence	16/1045	177/7206	0.0392837094777
ko05206	MicroRNAs in cancer	16/1045	177/7206	0.0392837094777
ko05145	Toxoplasmosis	10/1045	126/7206	0.0398595413574
ko00380	Tryptophan metabolism	2/1045	50/7206	0.0404344093497
ko04658	Th1 and Th2 cell differentiation	7/1045	96/7206	0.0410111093294
ko04145	Phagosome	33/1045	162/7206	0.0412792414226
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1045	182/7206	0.0429882343442
ko05133	Pertussis	6/1045	87/7206	0.0451428122922