ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1054	423/7206	7.09194578186e-54
ko04724	Glutamatergic synapse	87/1054	152/7206	6.29450018883e-35
ko05033	Nicotine addiction	49/1054	56/7206	3.85635024436e-34
ko04713	Circadian entrainment	78/1054	136/7206	1.82477650869e-31
ko05032	Morphine addiction	68/1054	110/7206	2.46519920372e-30
ko04727	GABAergic synapse	66/1054	110/7206	2.29238332762e-28
ko04728	Dopaminergic synapse	83/1054	185/7206	1.14923845325e-23
ko04725	Cholinergic synapse	74/1054	160/7206	3.51473327766e-22
ko04723	Retrograde endocannabinoid signaling	77/1054	175/7206	2.23909244653e-21
ko04721	Synaptic vesicle cycle	47/1054	80/7206	5.6540288125e-20
ko04024	cAMP signaling pathway	100/1054	279/7206	2.04431640622e-19
ko04911	Insulin secretion	56/1054	117/7206	6.59034361806e-18
ko04020	Calcium signaling pathway	92/1054	265/7206	7.37338947783e-17
ko04921	Oxytocin signaling pathway	76/1054	209/7206	2.03424137031e-15
ko04742	Taste transduction	34/1054	61/7206	7.41791898365e-14
ko04726	Serotonergic synapse	55/1054	137/7206	1.5707924298e-13
ko05031	Amphetamine addiction	42/1054	91/7206	4.62538065094e-13
ko04261	Adrenergic signaling in cardiomyocytes	70/1054	205/7206	1.15559675617e-12
ko04970	Salivary secretion	41/1054	95/7206	1.31355168312e-11
ko04744	Phototransduction	23/1054	36/7206	1.72889410188e-11
ko04720	Long-term potentiation	41/1054	99/7206	6.42923000898e-11
ko04925	Aldosterone synthesis and secretion	41/1054	105/7206	5.65470013678e-10
ko05030	Cocaine addiction	32/1054	73/7206	1.47457461651e-09
ko04971	Gastric acid secretion	38/1054	98/7206	3.06521302352e-09
ko03040	Spliceosome	1/1054	145/7206	3.5299535041e-09
ko04740	Olfactory transduction	33/1054	80/7206	5.40061282865e-09
ko04022	cGMP-PKG signaling pathway	62/1054	216/7206	6.93067339113e-08
ko05168	Herpes simplex infection	5/1054	182/7206	1.07737192394e-07
ko05203	Viral carcinogenesis	13/1054	277/7206	1.28773852624e-07
ko04060	Cytokine-cytokine receptor interaction	6/1054	191/7206	2.09018364756e-07
ko04972	Pancreatic secretion	37/1054	111/7206	5.04074824187e-07
ko05322	Systemic lupus erythematosus	4/1054	151/7206	1.15709836323e-06
ko04730	Long-term depression	28/1054	78/7206	2.29017776259e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1054	74/7206	2.4130705819e-06
ko04010	MAPK signaling pathway	78/1054	321/7206	3.26108224419e-06
ko04540	Gap junction	38/1054	128/7206	1.09581865289e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1054	79/7206	1.35030671339e-05
ko03013	RNA transport	7/1054	166/7206	1.9069482208e-05
ko04976	Bile secretion	26/1054	80/7206	4.26777997871e-05
ko04072	Phospholipase D signaling pathway	50/1054	197/7206	5.56705512404e-05
ko04260	Cardiac muscle contraction	30/1054	98/7206	6.48755303978e-05
ko05164	Influenza A	8/1054	167/7206	8.33371662555e-05
ko04360	Axon guidance	56/1054	233/7206	0.000100386562771
ko04141	Protein processing in endoplasmic reticulum	10/1054	184/7206	0.000118641363919
ko05414	Dilated cardiomyopathy	32/1054	112/7206	0.000119629303367
ko04070	Phosphatidylinositol signaling system	32/1054	112/7206	0.000119629303367
ko04745	Phototransduction - fly	15/1054	38/7206	0.000153258863313
ko04924	Renin secretion	26/1054	86/7206	0.000172728058488
ko04621	NOD-like receptor signaling pathway	8/1054	157/7206	0.00021838889035
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1054	59/7206	0.000244013874635
ko04915	Estrogen signaling pathway	35/1054	131/7206	0.000249179510938
ko05169	Epstein-Barr virus infection	13/1054	206/7206	0.000278022843717
ko05205	Proteoglycans in cancer	20/1054	271/7206	0.000298675078464
ko04110	Cell cycle	7/1054	145/7206	0.000302531532497
ko04750	Inflammatory mediator regulation of TRP channels	33/1054	122/7206	0.000385337453535
ko04120	Ubiquitin mediated proteolysis	7/1054	138/7206	0.000569237030816
ko04966	Collecting duct acid secretion	11/1054	26/7206	0.000580277774357
ko03008	Ribosome biogenesis in eukaryotes	2/1054	79/7206	0.00062689496063
ko04350	TGF-beta signaling pathway	4/1054	103/7206	0.000645974236866
ko04330	Notch signaling pathway	1/1054	62/7206	0.000957413767029
ko04514	Cell adhesion molecules (CAMs)	33/1054	130/7206	0.0010274851037
ko04923	Regulation of lipolysis in adipocytes	22/1054	77/7206	0.00162469886794
ko04964	Proximal tubule bicarbonate reclamation	11/1054	29/7206	0.00170824630515
ko05110	Vibrio cholerae infection	19/1054	63/7206	0.00172962399058
ko04973	Carbohydrate digestion and absorption	14/1054	42/7206	0.001809715383
ko04214	Apoptosis - fly	2/1054	72/7206	0.00205309129266
ko05161	Hepatitis B	12/1054	173/7206	0.0022100241004
ko04014	Ras signaling pathway	59/1054	279/7206	0.00244995811401
ko04630	Jak-STAT signaling pathway	8/1054	132/7206	0.00275105769736
ko00480	Glutathione metabolism	1/1054	55/7206	0.00327439653733
ko04610	Complement and coagulation cascades	3/1054	79/7206	0.00344740811571
ko05162	Measles	7/1054	120/7206	0.00385626931847
ko04912	GnRH signaling pathway	30/1054	122/7206	0.00402424416218
ko04371	Apelin signaling pathway	40/1054	177/7206	0.00478106251687
ko05140	Leishmaniasis	3/1054	75/7206	0.00488604170816
ko04612	Antigen processing and presentation	3/1054	77/7206	0.00505383063153
ko04064	NF-kappa B signaling pathway	5/1054	96/7206	0.00539397190297
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1054	182/7206	0.00552849804471
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1054	100/7206	0.0061167754437
ko00310	Lysine degradation	3/1054	73/7206	0.00700627215322
ko04217	Necroptosis	14/1054	178/7206	0.00716705581563
ko04918	Thyroid hormone synthesis	22/1054	86/7206	0.00808115969326
ko00240	Pyrimidine metabolism	7/1054	110/7206	0.00962318272395
ko05215	Prostate cancer	7/1054	111/7206	0.00963107333046
ko00562	Inositol phosphate metabolism	22/1054	89/7206	0.0099844018529
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1054	14/7206	0.0101244229428
ko04550	Signaling pathways regulating pluripotency of stem cells	13/1054	165/7206	0.0102369925744
ko05144	Malaria	1/1054	45/7206	0.0106872543281
ko00071	Fatty acid degradation	1/1054	45/7206	0.0106872543281
ko03420	Nucleotide excision repair	1/1054	46/7206	0.0107097507176
ko04930	Type II diabetes mellitus	15/1054	54/7206	0.0107487857559
ko05166	HTLV-I infection	28/1054	292/7206	0.0111032901728
ko05321	Inflammatory bowel disease (IBD)	2/1054	56/7206	0.0129365593647
ko05016	Huntington's disease	19/1054	215/7206	0.0139169762142
ko04657	IL-17 signaling pathway	5/1054	87/7206	0.0141798115009
ko04146	Peroxisome	5/1054	89/7206	0.0145611703221
ko04015	Rap1 signaling pathway	55/1054	278/7206	0.0153499549193
ko05202	Transcriptional misregulation in cancer	16/1054	188/7206	0.0156573259596
ko04658	Th1 and Th2 cell differentiation	6/1054	96/7206	0.0188380258768
ko05034	Alcoholism	48/1054	238/7206	0.0192226269784
ko03018	RNA degradation	5/1054	84/7206	0.0194208260499
ko05220	Chronic myeloid leukemia	5/1054	85/7206	0.019537620422
ko04115	p53 signaling pathway	4/1054	74/7206	0.0199588798344
ko00230	Purine metabolism	40/1054	194/7206	0.0228377402584
ko04922	Glucagon signaling pathway	28/1054	128/7206	0.0230747719345
ko00140	Steroid hormone biosynthesis	1/1054	41/7206	0.0239781077735
ko04210	Apoptosis	16/1054	180/7206	0.0247987622402
ko04140	Autophagy - animal	14/1054	164/7206	0.0248517525567
ko04062	Chemokine signaling pathway	41/1054	201/7206	0.0253149487616
ko05231	Choline metabolism in cancer	29/1054	134/7206	0.0257951721173
ko00330	Arginine and proline metabolism	3/1054	61/7206	0.0279505184923
ko04622	RIG-I-like receptor signaling pathway	3/1054	62/7206	0.0283628045875
ko04916	Melanogenesis	30/1054	142/7206	0.0308604002632
ko04270	Vascular smooth muscle contraction	32/1054	154/7206	0.0371303456997
ko04626	Plant-pathogen interaction	6/1054	18/7206	0.037369765078
ko03320	PPAR signaling pathway	4/1054	69/7206	0.038294771337
ko04978	Mineral absorption	11/1054	40/7206	0.0388277461114
ko04960	Aldosterone-regulated sodium reabsorption	11/1054	41/7206	0.041838969277
ko01524	Platinum drug resistance	5/1054	76/7206	0.0488110240531
ko05418	Fluid shear stress and atherosclerosis	16/1054	173/7206	0.0490256671233