ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 36/306 145/7206 1.30146266768e-18 ko04110 Cell cycle 33/306 145/7206 6.45301206177e-16 ko04111 Cell cycle - yeast 23/306 90/7206 1.46886684441e-12 ko03022 Basal transcription factors 14/306 44/7206 1.67646700436e-09 ko03013 RNA transport 26/306 166/7206 5.67778883113e-09 ko04113 Meiosis - yeast 16/306 70/7206 2.34260679922e-08 ko04080 Neuroactive ligand-receptor interaction 1/306 423/7206 2.82851300687e-07 ko03440 Homologous recombination 11/306 41/7206 6.82855538223e-07 ko03460 Fanconi anemia pathway 12/306 51/7206 9.91699945066e-07 ko05203 Viral carcinogenesis 29/306 277/7206 5.38882929421e-06 ko04114 Oocyte meiosis 18/306 139/7206 2.12350001936e-05 ko05322 Systemic lupus erythematosus 18/306 151/7206 6.52225784054e-05 ko03420 Nucleotide excision repair 9/306 46/7206 0.000109653824215 ko03410 Base excision repair 8/306 38/7206 0.000154682380789 ko03430 Mismatch repair 6/306 22/7206 0.000233918561551 ko04120 Ubiquitin mediated proteolysis 15/306 138/7206 0.000717611525365 ko03030 DNA replication 7/306 38/7206 0.000942039706372 ko04914 Progesterone-mediated oocyte maturation 12/306 104/7206 0.00143646500372 ko04144 Endocytosis 4/306 342/7206 0.00143825521095 ko03015 mRNA surveillance pathway 11/306 93/7206 0.00183786960109 ko03060 Protein export 5/306 23/7206 0.00239103028904 ko03018 RNA degradation 10/306 84/7206 0.00279295934886 ko05034 Alcoholism 20/306 238/7206 0.00297239146442 ko04014 Ras signaling pathway 3/306 279/7206 0.00359736610352 ko04218 Cellular senescence 16/306 177/7206 0.00380991578237 ko04060 Cytokine-cytokine receptor interaction 1/306 191/7206 0.0051900347147 ko04723 Retrograde endocannabinoid signaling 1/306 175/7206 0.00713003281239 ko04020 Calcium signaling pathway 3/306 265/7206 0.00732774325552 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/306 182/7206 0.00757590272449 ko04115 p53 signaling pathway 8/306 74/7206 0.0127218511725 ko04621 NOD-like receptor signaling pathway 1/306 157/7206 0.0149957857842 ko04072 Phospholipase D signaling pathway 2/306 197/7206 0.0180285803585 ko03008 Ribosome biogenesis in eukaryotes 8/306 79/7206 0.0183708194539 ko05205 Proteoglycans in cancer 4/306 271/7206 0.0196588488371 ko05169 Epstein-Barr virus infection 16/306 206/7206 0.0203166739756 ko04142 Lysosome 1/306 151/7206 0.0221431050091 ko04724 Glutamatergic synapse 1/306 152/7206 0.0223719370494 ko04270 Vascular smooth muscle contraction 1/306 154/7206 0.0229489434362 ko00240 Pyrimidine metabolism 10/306 110/7206 0.026222205119 ko04151 PI3K-Akt signaling pathway 8/306 390/7206 0.0270093515391 ko04713 Circadian entrainment 1/306 136/7206 0.0311100707078 ko04931 Insulin resistance 1/306 137/7206 0.0311284006486 ko04712 Circadian rhythm - plant 2/306 7/7206 0.03276364661 ko03020 RNA polymerase 4/306 29/7206 0.0327761249198 ko04024 cAMP signaling pathway 5/306 279/7206 0.0335164235587 ko05224 Breast cancer 2/306 174/7206 0.0349434915245 ko04371 Apelin signaling pathway 2/306 177/7206 0.0353735426221 ko04210 Apoptosis 2/306 180/7206 0.0362232742572 ko05168 Herpes simplex infection 14/306 182/7206 0.0370226925939 ko04022 cGMP-PKG signaling pathway 3/306 216/7206 0.0370508310822 ko00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 3/306 19/7206 0.0443800535976 ko05145 Toxoplasmosis 1/306 126/7206 0.044731453534 ko01200 Carbon metabolism 1/306 128/7206 0.0447934554158 ko04380 Osteoclast differentiation 1/306 134/7206 0.0467464222545 ko04360 Axon guidance 4/306 233/7206 0.0473344871235 ko04510 Focal adhesion 4/306 240/7206 0.0482473891185 ko04145 Phagosome 2/306 162/7206 0.0487387779174 ko04140 Autophagy - animal 2/306 164/7206 0.0487847353893 ko05164 Influenza A 2/306 167/7206 0.0493145134072