ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 154/929 423/7206 1.44147645764e-37 ko04724 Glutamatergic synapse 78/929 152/7206 6.87539662984e-31 ko05033 Nicotine addiction 42/929 56/7206 1.80556711485e-26 ko05032 Morphine addiction 57/929 110/7206 4.35133116252e-23 ko04721 Synaptic vesicle cycle 47/929 80/7206 2.48344647267e-22 ko04728 Dopaminergic synapse 75/929 185/7206 1.2039839831e-21 ko04713 Circadian entrainment 60/929 136/7206 1.06481966594e-19 ko04727 GABAergic synapse 53/929 110/7206 1.142105014e-19 ko04725 Cholinergic synapse 63/929 160/7206 1.39998085821e-17 ko04723 Retrograde endocannabinoid signaling 65/929 175/7206 1.37281813972e-16 ko04024 cAMP signaling pathway 84/929 279/7206 9.31062103409e-15 ko04921 Oxytocin signaling pathway 66/929 209/7206 8.6576561622e-13 ko04020 Calcium signaling pathway 75/929 265/7206 9.05280811048e-12 ko04726 Serotonergic synapse 48/929 137/7206 1.71246758652e-11 ko05031 Amphetamine addiction 37/929 91/7206 2.53898780763e-11 ko04911 Insulin secretion 42/929 117/7206 1.33981463331e-10 ko04744 Phototransduction 21/929 36/7206 1.37982578791e-10 ko04742 Taste transduction 28/929 61/7206 2.32259963642e-10 ko04720 Long-term potentiation 37/929 99/7206 4.57072427373e-10 ko04261 Adrenergic signaling in cardiomyocytes 58/929 205/7206 2.33308692242e-09 ko03040 Spliceosome 1/929 145/7206 5.77688605309e-08 ko05030 Cocaine addiction 26/929 73/7206 5.461583193e-07 ko04966 Collecting duct acid secretion 14/929 26/7206 6.8437101034e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 26/929 74/7206 7.40540719022e-07 ko04970 Salivary secretion 30/929 95/7206 1.44963977335e-06 ko05203 Viral carcinogenesis 12/929 277/7206 1.52675315759e-06 ko04925 Aldosterone synthesis and secretion 32/929 105/7206 2.02082211598e-06 ko04060 Cytokine-cytokine receptor interaction 6/929 191/7206 4.87154151946e-06 ko04010 MAPK signaling pathway 69/929 321/7206 1.15058639628e-05 ko05168 Herpes simplex infection 6/929 182/7206 1.45300154853e-05 ko03013 RNA transport 5/929 166/7206 1.71637176901e-05 ko05322 Systemic lupus erythematosus 4/929 151/7206 2.02452986474e-05 ko05110 Vibrio cholerae infection 21/929 63/7206 2.17439310734e-05 ko04360 Axon guidance 53/929 233/7206 2.40843954792e-05 ko04971 Gastric acid secretion 28/929 98/7206 2.80174940828e-05 ko04745 Phototransduction - fly 15/929 38/7206 3.47390483683e-05 ko04514 Cell adhesion molecules (CAMs) 34/929 130/7206 4.96992766662e-05 ko04120 Ubiquitin mediated proteolysis 4/929 138/7206 8.71744486975e-05 ko04730 Long-term depression 23/929 78/7206 0.000100816406782 ko04022 cGMP-PKG signaling pathway 48/929 216/7206 0.000115201954441 ko04740 Olfactory transduction 23/929 80/7206 0.000139294724247 ko04621 NOD-like receptor signaling pathway 6/929 157/7206 0.00015813004401 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 22/929 79/7206 0.000304157566548 ko03008 Ribosome biogenesis in eukaryotes 1/929 79/7206 0.000508423009471 ko05164 Influenza A 8/929 167/7206 0.00063900874264 ko04260 Cardiac muscle contraction 25/929 98/7206 0.000648466366535 ko04014 Ras signaling pathway 56/929 279/7206 0.00068289969736 ko04972 Pancreatic secretion 27/929 111/7206 0.000859351494266 ko04070 Phosphatidylinositol signaling system 27/929 112/7206 0.000949010720617 ko04626 Plant-pathogen interaction 8/929 18/7206 0.000981227747881 ko04141 Protein processing in endoplasmic reticulum 10/929 184/7206 0.00113457416325 ko04915 Estrogen signaling pathway 30/929 131/7206 0.0013885141341 ko05120 Epithelial cell signaling in Helicobacter pylori infection 23/929 92/7206 0.0014206023653 ko04110 Cell cycle 7/929 145/7206 0.00164313805892 ko04924 Renin secretion 22/929 86/7206 0.00164565566444 ko04064 NF-kappa B signaling pathway 3/929 96/7206 0.00184046298989 ko04540 Gap junction 29/929 128/7206 0.00196960287102 ko05205 Proteoglycans in cancer 19/929 271/7206 0.00219175442086 ko05162 Measles 5/929 120/7206 0.00220881949129 ko04961 Endocrine and other factor-regulated calcium reabsorption 16/929 59/7206 0.00281141540882 ko05169 Epstein-Barr virus infection 13/929 206/7206 0.00294720131629 ko04612 Antigen processing and presentation 2/929 77/7206 0.00317496784896 ko04610 Complement and coagulation cascades 2/929 79/7206 0.00336390336531 ko04750 Inflammatory mediator regulation of TRP channels 27/929 122/7206 0.00392668361085 ko05166 HTLV-I infection 22/929 292/7206 0.00417523849857 ko05140 Leishmaniasis 2/929 75/7206 0.00472585481198 ko04072 Phospholipase D signaling pathway 39/929 197/7206 0.00496896385798 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/929 14/7206 0.00540514163664 ko04214 Apoptosis - fly 2/929 72/7206 0.00688287018426 ko04930 Type II diabetes mellitus 14/929 54/7206 0.00765109481248 ko00480 Glutathione metabolism 1/929 55/7206 0.00772329094963 ko05161 Hepatitis B 11/929 173/7206 0.00782837360265 ko04964 Proximal tubule bicarbonate reclamation 9/929 29/7206 0.00854646074921 ko05414 Dilated cardiomyopathy 24/929 112/7206 0.0100708238331 ko00590 Arachidonic acid metabolism 1/929 52/7206 0.0114494266012 ko00240 Pyrimidine metabolism 6/929 110/7206 0.014536846515 ko04146 Peroxisome 4/929 89/7206 0.0156413071743 ko04922 Glucagon signaling pathway 26/929 128/7206 0.0160381707828 ko05219 Bladder cancer 1/929 48/7206 0.0168696558257 ko00330 Arginine and proline metabolism 2/929 61/7206 0.0199024026065 ko04330 Notch signaling pathway 2/929 62/7206 0.0202912393464 ko00310 Lysine degradation 3/929 73/7206 0.0211489907199 ko05323 Rheumatoid arthritis 19/929 89/7206 0.0244143432686 ko05010 Alzheimer's disease 37/929 202/7206 0.0248331681087 ko00071 Fatty acid degradation 1/929 45/7206 0.0248596746281 ko03420 Nucleotide excision repair 1/929 46/7206 0.0250776381925 ko04350 TGF-beta signaling pathway 6/929 103/7206 0.0263227247638 ko00512 Mucin type O-glycan biosynthesis 8/929 29/7206 0.0264645746463 ko04114 Oocyte meiosis 27/929 139/7206 0.0286848648069 ko04510 Focal adhesion 20/929 240/7206 0.0308948359635 ko04630 Jak-STAT signaling pathway 9/929 132/7206 0.0352093770388 ko00983 Drug metabolism - other enzymes 1/929 42/7206 0.0365876989587 ko03022 Basal transcription factors 1/929 44/7206 0.0381390677063 ko00280 Valine, leucine and isoleucine degradation 2/929 54/7206 0.0404353537722 ko04371 Apelin signaling pathway 32/929 177/7206 0.0409971803405 ko05321 Inflammatory bowel disease (IBD) 2/929 56/7206 0.0419124146991 ko05410 Hypertrophic cardiomyopathy (HCM) 20/929 100/7206 0.0486658707508 ko05034 Alcoholism 41/929 238/7206 0.0486982307879