ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	172/999	423/7206	2.56161152652e-45
ko04724	Glutamatergic synapse	81/999	152/7206	2.81027722133e-31
ko05033	Nicotine addiction	44/999	56/7206	7.95677327807e-28
ko05032	Morphine addiction	61/999	110/7206	5.17102204232e-25
ko04727	GABAergic synapse	57/999	110/7206	1.72995143939e-21
ko04713	Circadian entrainment	64/999	136/7206	4.44235114856e-21
ko04721	Synaptic vesicle cycle	46/999	80/7206	5.1572548823e-20
ko04728	Dopaminergic synapse	73/999	185/7206	2.02064518464e-18
ko04024	cAMP signaling pathway	93/999	279/7206	2.28605301899e-17
ko04725	Cholinergic synapse	65/999	160/7206	2.80813146638e-17
ko04723	Retrograde endocannabinoid signaling	68/999	175/7206	8.1092589003e-17
ko04921	Oxytocin signaling pathway	74/999	209/7206	1.32083177351e-15
ko04020	Calcium signaling pathway	86/999	265/7206	2.55560726085e-15
ko04911	Insulin secretion	49/999	117/7206	6.27666698363e-14
ko04742	Taste transduction	32/999	61/7206	8.45090561679e-13
ko04726	Serotonergic synapse	50/999	137/7206	1.7388740189e-11
ko04744	Phototransduction	22/999	36/7206	5.84751665692e-11
ko05031	Amphetamine addiction	37/999	91/7206	2.18860683379e-10
ko04970	Salivary secretion	38/999	95/7206	2.21001214226e-10
ko04261	Adrenergic signaling in cardiomyocytes	63/999	205/7206	2.2838531344e-10
ko04720	Long-term potentiation	38/999	99/7206	9.10354738425e-10
ko03040	Spliceosome	1/999	145/7206	1.44706837951e-08
ko04022	cGMP-PKG signaling pathway	59/999	216/7206	1.18956738615e-07
ko05203	Viral carcinogenesis	12/999	277/7206	1.83366334671e-07
ko04925	Aldosterone synthesis and secretion	35/999	105/7206	4.04053626114e-07
ko04971	Gastric acid secretion	33/999	98/7206	4.46585143598e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	27/999	74/7206	8.28826942685e-07
ko04740	Olfactory transduction	28/999	80/7206	1.37850380193e-06
ko05168	Herpes simplex infection	6/999	182/7206	2.08829703435e-06
ko05030	Cocaine addiction	26/999	73/7206	2.24590467846e-06
ko05322	Systemic lupus erythematosus	4/999	151/7206	3.95916586133e-06
ko04010	MAPK signaling pathway	74/999	321/7206	6.56214408704e-06
ko04360	Axon guidance	57/999	233/7206	1.11415915702e-05
ko05164	Influenza A	6/999	167/7206	1.26640492434e-05
ko04060	Cytokine-cytokine receptor interaction	8/999	191/7206	1.62761231803e-05
ko04745	Phototransduction - fly	16/999	38/7206	1.82953572206e-05
ko04514	Cell adhesion molecules (CAMs)	36/999	130/7206	2.84905926482e-05
ko05169	Epstein-Barr virus infection	10/999	206/7206	3.46143029855e-05
ko04972	Pancreatic secretion	32/999	111/7206	3.70670898533e-05
ko04730	Long-term depression	25/999	78/7206	3.71841021366e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/999	79/7206	4.39623207833e-05
ko04621	NOD-like receptor signaling pathway	6/999	157/7206	5.38155445657e-05
ko03013	RNA transport	7/999	166/7206	5.74221532499e-05
ko04966	Collecting duct acid secretion	12/999	26/7206	6.97879322233e-05
ko04120	Ubiquitin mediated proteolysis	5/999	138/7206	9.2464457378e-05
ko04260	Cardiac muscle contraction	28/999	98/7206	0.000157880745962
ko04924	Renin secretion	25/999	86/7206	0.000209606922646
ko05205	Proteoglycans in cancer	18/999	271/7206	0.000214269331706
ko04141	Protein processing in endoplasmic reticulum	10/999	184/7206	0.000318734091714
ko04110	Cell cycle	7/999	145/7206	0.000594653000902
ko04540	Gap junction	32/999	128/7206	0.000671084573222
ko05110	Vibrio cholerae infection	19/999	63/7206	0.000692111993584
ko05162	Measles	5/999	120/7206	0.000752169278334
ko04070	Phosphatidylinositol signaling system	29/999	112/7206	0.000756103537596
ko04964	Proximal tubule bicarbonate reclamation	11/999	29/7206	0.00108834111066
ko04750	Inflammatory mediator regulation of TRP channels	30/999	122/7206	0.00132686908775
ko05414	Dilated cardiomyopathy	28/999	112/7206	0.00136533927573
ko04612	Antigen processing and presentation	2/999	77/7206	0.00141470432329
ko04610	Complement and coagulation cascades	2/999	79/7206	0.00147294768995
ko03008	Ribosome biogenesis in eukaryotes	2/999	79/7206	0.00147294768995
ko04626	Plant-pathogen interaction	8/999	18/7206	0.00159693361599
ko04146	Peroxisome	3/999	89/7206	0.00173533169792
ko05166	HTLV-I infection	23/999	292/7206	0.00176786542933
ko04915	Estrogen signaling pathway	31/999	131/7206	0.00205265136458
ko05140	Leishmaniasis	2/999	75/7206	0.00208461975145
ko04630	Jak-STAT signaling pathway	7/999	132/7206	0.00213864959662
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/999	59/7206	0.00217923455946
ko00330	Arginine and proline metabolism	1/999	61/7206	0.00228871487948
ko05161	Hepatitis B	11/999	173/7206	0.00246102114236
ko04371	Apelin signaling pathway	39/999	177/7206	0.00273327843652
ko04064	NF-kappa B signaling pathway	4/999	96/7206	0.00274911296274
ko04922	Glucagon signaling pathway	30/999	128/7206	0.00283665852163
ko04072	Phospholipase D signaling pathway	42/999	197/7206	0.00332796739974
ko04014	Ras signaling pathway	56/999	279/7206	0.00342147386191
ko00480	Glutathione metabolism	1/999	55/7206	0.00506515257537
ko05410	Hypertrophic cardiomyopathy (HCM)	24/999	100/7206	0.00534450502086
ko00240	Pyrimidine metabolism	6/999	110/7206	0.0076612201141
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/999	14/7206	0.00777401352841
ko04330	Notch signaling pathway	2/999	62/7206	0.00922113983602
ko05219	Bladder cancer	1/999	48/7206	0.0109920748787
ko04550	Signaling pathways regulating pluripotency of stem cells	12/999	165/7206	0.0116819106032
ko04114	Oocyte meiosis	30/999	139/7206	0.0124793666707
ko00562	Inositol phosphate metabolism	21/999	89/7206	0.0125090675741
ko04710	Circadian rhythm	12/999	43/7206	0.0132706986971
ko04350	TGF-beta signaling pathway	6/999	103/7206	0.0140613346752
ko04976	Bile secretion	19/999	80/7206	0.0143370795431
ko04214	Apoptosis - fly	3/999	72/7206	0.0148750778129
ko00071	Fatty acid degradation	1/999	45/7206	0.0162938809136
ko03420	Nucleotide excision repair	1/999	46/7206	0.0165204014125
ko05215	Prostate cancer	7/999	111/7206	0.0178894552301
ko05321	Inflammatory bowel disease (IBD)	2/999	56/7206	0.0191729516304
ko04923	Regulation of lipolysis in adipocytes	18/999	77/7206	0.0200676862066
ko03022	Basal transcription factors	1/999	44/7206	0.025278220465
ko05220	Chronic myeloid leukemia	5/999	85/7206	0.0271435784525
ko04657	IL-17 signaling pathway	5/999	87/7206	0.0274425486345
ko00280	Valine, leucine and isoleucine degradation	2/999	54/7206	0.0277630432278
ko04640	Hematopoietic cell lineage	3/999	64/7206	0.0285698856908
ko05120	Epithelial cell signaling in Helicobacter pylori infection	20/999	92/7206	0.0333211071208
ko04510	Focal adhesion	22/999	240/7206	0.0359580295456
ko00980	Metabolism of xenobiotics by cytochrome P450	1/999	40/7206	0.0360370312991
ko04217	Necroptosis	15/999	178/7206	0.0361083413605
ko00140	Steroid hormone biosynthesis	1/999	41/7206	0.0372342369567
ko03018	RNA degradation	5/999	84/7206	0.0372408998716
ko00310	Lysine degradation	4/999	73/7206	0.0392270576455
ko00380	Tryptophan metabolism	2/999	50/7206	0.039354847631
ko04115	p53 signaling pathway	4/999	74/7206	0.0400719372225
ko04622	RIG-I-like receptor signaling pathway	3/999	62/7206	0.0403189272612
ko00561	Glycerolipid metabolism	3/999	63/7206	0.0412223245777
ko04930	Type II diabetes mellitus	13/999	54/7206	0.0446103155154
ko04912	GnRH signaling pathway	25/999	122/7206	0.0459609795694
ko05010	Alzheimer's disease	38/999	202/7206	0.0488962562875