ko pathway ratio_in_study ratio_in_pop p_value ko05033 Nicotine addiction 8/55 56/7206 7.27941804201e-09 ko04727 GABAergic synapse 10/55 110/7206 7.48561963119e-09 ko04723 Retrograde endocannabinoid signaling 11/55 175/7206 5.99058518768e-08 ko05032 Morphine addiction 9/55 110/7206 1.14545521538e-07 ko04261 Adrenergic signaling in cardiomyocytes 8/55 205/7206 0.000144324554861 ko04721 Synaptic vesicle cycle 5/55 80/7206 0.000334992116758 ko04020 Calcium signaling pathway 8/55 265/7206 0.000816443454931 ko04742 Taste transduction 4/55 61/7206 0.00114827030195 ko05414 Dilated cardiomyopathy 5/55 112/7206 0.0015541593829 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 4/55 79/7206 0.00298739172546 ko04080 Neuroactive ligand-receptor interaction 9/55 423/7206 0.00432998965568 ko04921 Oxytocin signaling pathway 6/55 209/7206 0.00491328940385 ko04024 cAMP signaling pathway 7/55 279/7206 0.0049911881227 ko04022 cGMP-PKG signaling pathway 6/55 216/7206 0.00576156100114 ko04724 Glutamatergic synapse 5/55 152/7206 0.0058223925188 ko04260 Cardiac muscle contraction 4/55 98/7206 0.00645550112945 ko05410 Hypertrophic cardiomyopathy (HCM) 4/55 100/7206 0.00692949953751 ko04972 Pancreatic secretion 4/55 111/7206 0.00995147253079 ko04713 Circadian entrainment 4/55 136/7206 0.0197038066178 ko04725 Cholinergic synapse 4/55 160/7206 0.0332567187864 ko04970 Salivary secretion 3/55 95/7206 0.0355690612518 ko04371 Apelin signaling pathway 4/55 177/7206 0.0455008046766 ko04925 Aldosterone synthesis and secretion 3/55 105/7206 0.0456944114364