ko pathway ratio_in_study ratio_in_pop p_value ko00120 Primary bile acid biosynthesis 11/451 20/7206 5.14320142119e-09 ko04380 Osteoclast differentiation 24/451 134/7206 2.27730870372e-06 ko04146 Peroxisome 18/451 89/7206 7.42210807331e-06 ko05340 Primary immunodeficiency 10/451 30/7206 8.04745727329e-06 ko05321 Inflammatory bowel disease (IBD) 13/451 56/7206 3.00368667486e-05 ko04137 Mitophagy - animal 16/451 82/7206 3.80582297193e-05 ko05150 Staphylococcus aureus infection 10/451 36/7206 4.84283540219e-05 ko04060 Cytokine-cytokine receptor interaction 27/451 191/7206 5.45149418867e-05 ko03320 PPAR signaling pathway 14/451 69/7206 7.40050486567e-05 ko04650 Natural killer cell mediated cytotoxicity 17/451 97/7206 9.14379429645e-05 ko04610 Complement and coagulation cascades 15/451 79/7206 9.20669908301e-05 ko04662 B cell receptor signaling pathway 16/451 88/7206 9.31735496693e-05 ko05145 Toxoplasmosis 20/451 126/7206 9.61637619598e-05 ko05164 Influenza A 24/451 167/7206 0.000119902231615 ko05162 Measles 19/451 120/7206 0.000148144137784 ko05140 Leishmaniasis 14/451 75/7206 0.000189863917409 ko00362 Benzoate degradation 4/451 6/7206 0.000205305527219 ko00380 Tryptophan metabolism 11/451 50/7206 0.000205514831281 ko04064 NF-kappa B signaling pathway 16/451 96/7206 0.000268036861817 ko05034 Alcoholism 3/451 238/7206 0.000310625353113 ko00071 Fatty acid degradation 10/451 45/7206 0.000365346852938 ko04620 Toll-like receptor signaling pathway 16/451 100/7206 0.000432114590162 ko03013 RNA transport 1/451 166/7206 0.000484625022452 ko05152 Tuberculosis 24/451 187/7206 0.00064451788809 ko04630 Jak-STAT signaling pathway 19/451 132/7206 0.00070174941415 ko04659 Th17 cell differentiation 16/451 106/7206 0.000836891880829 ko04660 T cell receptor signaling pathway 18/451 124/7206 0.000961716803259 ko04390 Hippo signaling pathway 2/451 188/7206 0.00105770331001 ko04621 NOD-like receptor signaling pathway 21/451 157/7206 0.0011413594606 ko03040 Spliceosome 1/451 145/7206 0.00149575941201 ko04110 Cell cycle 1/451 145/7206 0.00149575941201 ko05167 Kaposi's sarcoma-associated herpesvirus infection 23/451 191/7206 0.00215535964447 ko04723 Retrograde endocannabinoid signaling 2/451 175/7206 0.00217299175096 ko04217 Necroptosis 22/451 178/7206 0.00235513656617 ko04658 Th1 and Th2 cell differentiation 14/451 96/7206 0.0024261334133 ko05168 Herpes simplex infection 22/451 182/7206 0.00273408362416 ko04612 Antigen processing and presentation 12/451 77/7206 0.00276820543403 ko00051 Fructose and mannose metabolism 8/451 42/7206 0.00395634180842 ko00590 Arachidonic acid metabolism 9/451 52/7206 0.00448867741938 ko04611 Platelet activation 20/451 163/7206 0.00453014489999 ko04310 Wnt signaling pathway 3/451 181/7206 0.00484333710318 ko03010 Ribosome 1/451 129/7206 0.00484934338321 ko00592 alpha-Linolenic acid metabolism 5/451 19/7206 0.00524686448698 ko04640 Hematopoietic cell lineage 10/451 64/7206 0.00597537235911 ko04724 Glutamatergic synapse 2/451 152/7206 0.00601025552946 ko05144 Malaria 8/451 45/7206 0.00613045170437 ko05224 Breast cancer 3/451 174/7206 0.00678440965542 ko00982 Drug metabolism - cytochrome P450 7/451 37/7206 0.00717160862459 ko05204 Chemical carcinogenesis 8/451 48/7206 0.00911009763424 ko05160 Hepatitis C 18/451 153/7206 0.00991023691318 ko04136 Autophagy - other 6/451 31/7206 0.0112129692828 ko00140 Steroid hormone biosynthesis 7/451 41/7206 0.0126289546776 ko04623 Cytosolic DNA-sensing pathway 7/451 41/7206 0.0126289546776 ko00330 Arginine and proline metabolism 9/451 61/7206 0.0128771834344 ko04622 RIG-I-like receptor signaling pathway 9/451 62/7206 0.0142586176176 ko00983 Drug metabolism - other enzymes 7/451 42/7206 0.0143634772512 ko00830 Retinol metabolism 7/451 42/7206 0.0143634772512 ko00220 Arginine biosynthesis 5/451 24/7206 0.0148159833254 ko00350 Tyrosine metabolism 6/451 33/7206 0.0151799626291 ko04972 Pancreatic secretion 1/451 111/7206 0.0152345321961 ko04710 Circadian rhythm 7/451 43/7206 0.0162616705762 ko00360 Phenylalanine metabolism 4/451 17/7206 0.0187654713549 ko00480 Glutathione metabolism 8/451 55/7206 0.0200942184196 ko05200 Pathways in cancer 19/451 492/7206 0.020466645957 ko00950 Isoquinoline alkaloid biosynthesis 3/451 10/7206 0.0209953682169 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/451 4/7206 0.0215501445543 ko04540 Gap junction 2/451 128/7206 0.0247007978141 ko04672 Intestinal immune network for IgA production 6/451 37/7206 0.0258312173926 ko04664 Fc epsilon RI signaling pathway 10/451 77/7206 0.0277498895283 ko04080 Neuroactive ligand-receptor interaction 16/451 423/7206 0.0293052847625 ko04010 MAPK signaling pathway 11/451 321/7206 0.0328848187114 ko00281 Geraniol degradation 2/451 5/7206 0.0344404654059 ko04916 Melanogenesis 3/451 142/7206 0.0347866056526 ko00980 Metabolism of xenobiotics by cytochrome P450 6/451 40/7206 0.0364697274068 ko04142 Lysosome 16/451 151/7206 0.0388870476928 ko04728 Dopaminergic synapse 5/451 185/7206 0.0440049500994 ko04391 Hippo signaling pathway - fly 1/451 90/7206 0.044457557221 ko05032 Morphine addiction 2/451 110/7206 0.0472102937572