ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 26/247 134/7206 3.09890948124e-13 ko04668 TNF signaling pathway 21/247 120/7206 5.01296816034e-10 ko05133 Pertussis 16/247 87/7206 3.00637882684e-08 ko04621 NOD-like receptor signaling pathway 21/247 157/7206 7.20214577254e-08 ko04623 Cytosolic DNA-sensing pathway 11/247 41/7206 7.81052359967e-08 ko05164 Influenza A 21/247 167/7206 2.11464181537e-07 ko04060 Cytokine-cytokine receptor interaction 22/247 191/7206 5.0889177537e-07 ko05323 Rheumatoid arthritis 14/247 89/7206 1.6443655688e-06 ko04657 IL-17 signaling pathway 13/247 87/7206 7.01728167662e-06 ko05140 Leishmaniasis 12/247 75/7206 7.7162648824e-06 ko04660 T cell receptor signaling pathway 15/247 124/7206 1.95792419117e-05 ko05161 Hepatitis B 18/247 173/7206 2.38123940597e-05 ko04620 Toll-like receptor signaling pathway 13/247 100/7206 3.27908505636e-05 ko04662 B cell receptor signaling pathway 12/247 88/7206 4.08421825956e-05 ko04622 RIG-I-like receptor signaling pathway 10/247 62/7206 4.17144015303e-05 ko04610 Complement and coagulation cascades 11/247 79/7206 7.04949655808e-05 ko05418 Fluid shear stress and atherosclerosis 17/247 173/7206 8.32469325918e-05 ko04064 NF-kappa B signaling pathway 12/247 96/7206 9.74180884534e-05 ko05131 Shigellosis 11/247 82/7206 9.97518934967e-05 ko05132 Salmonella infection 12/247 98/7206 0.00011921863322 ko05142 Chagas disease (American trypanosomiasis) 14/247 130/7206 0.000134401501061 ko00643 Styrene degradation 3/247 4/7206 0.000155160041226 ko04666 Fc gamma R-mediated phagocytosis 13/247 122/7206 0.000259117465203 ko05167 Kaposi's sarcoma-associated herpesvirus infection 17/247 191/7206 0.000278972922723 ko05145 Toxoplasmosis 13/247 126/7206 0.000356657018182 ko04210 Apoptosis 16/247 180/7206 0.000427360911817 ko05168 Herpes simplex infection 16/247 182/7206 0.000483465966704 ko04630 Jak-STAT signaling pathway 13/247 132/7206 0.000560736525386 ko05152 Tuberculosis 16/247 187/7206 0.000652160270971 ko04933 AGE-RAGE signaling pathway in diabetic complications 13/247 135/7206 0.000695253764357 ko05120 Epithelial cell signaling in Helicobacter pylori infection 10/247 92/7206 0.00113624091106 ko05150 Staphylococcus aureus infection 6/247 36/7206 0.00125193078885 ko04672 Intestinal immune network for IgA production 6/247 37/7206 0.00145207860192 ko05160 Hepatitis C 13/247 153/7206 0.00220318832221 ko05210 Colorectal cancer 9/247 86/7206 0.00259593297503 ko05162 Measles 11/247 120/7206 0.00263094761381 ko05134 Legionellosis 8/247 74/7206 0.00363093680373 ko01524 Platinum drug resistance 8/247 76/7206 0.0042842210242 ko04650 Natural killer cell mediated cytotoxicity 9/247 97/7206 0.00582807626195 ko05100 Bacterial invasion of epithelial cells 9/247 99/7206 0.00665485573755 ko05146 Amoebiasis 9/247 99/7206 0.00665485573755 ko00982 Drug metabolism - cytochrome P450 5/247 37/7206 0.00807721933192 ko04917 Prolactin signaling pathway 8/247 87/7206 0.00962912900372 ko04062 Chemokine signaling pathway 14/247 201/7206 0.0098205103137 ko04217 Necroptosis 13/247 178/7206 0.00984372543556 ko04932 Non-alcoholic fatty liver disease (NAFLD) 13/247 182/7206 0.0111556913838 ko00980 Metabolism of xenobiotics by cytochrome P450 5/247 40/7206 0.0112223101312 ko04611 Platelet activation 12/247 163/7206 0.0131843196027 ko04658 Th1 and Th2 cell differentiation 8/247 96/7206 0.0168219410264 ko05034 Alcoholism 2/247 238/7206 0.0177991095321 ko05144 Malaria 5/247 45/7206 0.0181558697518 ko04670 Leukocyte transendothelial migration 11/247 151/7206 0.0192863303457 ko04144 Endocytosis 20/247 342/7206 0.0206363812094 ko04215 Apoptosis - multiple species 5/247 47/7206 0.0215770660026 ko05204 Chemical carcinogenesis 5/247 48/7206 0.0234346866456 ko04624 Toll and Imd signaling pathway 5/247 49/7206 0.0253926694796 ko04931 Insulin resistance 10/247 137/7206 0.0269950372936 ko04659 Th17 cell differentiation 8/247 106/7206 0.0286500805722 ko05166 HTLV-I infection 17/247 292/7206 0.030900105414 ko04723 Retrograde endocannabinoid signaling 1/247 175/7206 0.0321298647623 ko04920 Adipocytokine signaling pathway 7/247 89/7206 0.0324991997917 ko04080 Neuroactive ligand-receptor interaction 7/247 423/7206 0.0378297200723 ko05416 Viral myocarditis 5/247 55/7206 0.0393274922306 ko04115 p53 signaling pathway 6/247 74/7206 0.0406903684547 ko05321 Inflammatory bowel disease (IBD) 5/247 56/7206 0.0420247263756 ko05020 Prion diseases 4/247 40/7206 0.0469260871762 ko04664 Fc epsilon RI signaling pathway 6/247 77/7206 0.0479089655693