ko pathway ratio_in_study ratio_in_pop p_value ko04110 Cell cycle 41/358 145/7206 8.34843212072e-21 ko04111 Cell cycle - yeast 31/358 90/7206 9.63712156108e-19 ko05322 Systemic lupus erythematosus 35/358 151/7206 6.00693360297e-15 ko03440 Homologous recombination 18/358 41/7206 1.58334988826e-13 ko04113 Meiosis - yeast 20/358 70/7206 8.20356832634e-11 ko03030 DNA replication 15/358 38/7206 1.12954013466e-10 ko03460 Fanconi anemia pathway 17/358 51/7206 1.47477827861e-10 ko05034 Alcoholism 36/358 238/7206 1.33778495124e-09 ko04080 Neuroactive ligand-receptor interaction 1/358 423/7206 1.05441694335e-08 ko05203 Viral carcinogenesis 37/358 277/7206 2.51402988064e-08 ko03410 Base excision repair 12/358 38/7206 1.57821192392e-07 ko03040 Spliceosome 23/358 145/7206 6.08790888099e-07 ko03430 Mismatch repair 8/358 22/7206 5.94298397496e-06 ko04330 Notch signaling pathway 12/358 62/7206 4.26678341838e-05 ko05202 Transcriptional misregulation in cancer 23/358 188/7206 5.16450296774e-05 ko03018 RNA degradation 14/358 84/7206 5.7393910536e-05 ko04144 Endocytosis 4/358 342/7206 0.000184303122274 ko00310 Lysine degradation 12/358 73/7206 0.000221624269732 ko04022 cGMP-PKG signaling pathway 1/358 216/7206 0.000342436123869 ko04151 PI3K-Akt signaling pathway 6/358 390/7206 0.000442047569846 ko05010 Alzheimer's disease 1/358 202/7206 0.000755797247384 ko00240 Pyrimidine metabolism 14/358 110/7206 0.00102750902233 ko04020 Calcium signaling pathway 3/358 265/7206 0.00128578739009 ko05206 MicroRNAs in cancer 19/358 177/7206 0.00130400784741 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/358 182/7206 0.00155931584368 ko04728 Dopaminergic synapse 1/358 185/7206 0.00159499474564 ko04114 Oocyte meiosis 16/358 139/7206 0.00216606935806 ko04010 MAPK signaling pathway 5/358 321/7206 0.00218809022156 ko04024 cAMP signaling pathway 4/358 279/7206 0.00281188193578 ko04261 Adrenergic signaling in cardiomyocytes 2/358 205/7206 0.00303578303048 ko04510 Focal adhesion 3/358 240/7206 0.00359813681477 ko04062 Chemokine signaling pathway 2/358 201/7206 0.00441153678054 ko04071 Sphingolipid signaling pathway 1/358 162/7206 0.00500648737638 ko04611 Platelet activation 1/358 163/7206 0.00508525545306 ko04140 Autophagy - animal 1/358 164/7206 0.00517873051832 ko03420 Nucleotide excision repair 7/358 46/7206 0.00705576660712 ko05160 Hepatitis C 1/358 153/7206 0.0071833747415 ko05166 HTLV-I infection 25/358 292/7206 0.00815638948325 ko04210 Apoptosis 2/358 180/7206 0.0087545671632 ko05152 Tuberculosis 2/358 187/7206 0.00915272497632 ko04810 Regulation of actin cytoskeleton 5/358 264/7206 0.013773413119 ko05205 Proteoglycans in cancer 5/358 271/7206 0.0142299413997 ko04933 AGE-RAGE signaling pathway in diabetic complications 1/358 135/7206 0.0148424353743 ko04392 Hippo signaling pathway -multiple species 5/358 31/7206 0.0172099460983 ko01200 Carbon metabolism 1/358 128/7206 0.021620291543 ko05142 Chagas disease (American trypanosomiasis) 1/358 130/7206 0.022099083752 ko04514 Cell adhesion molecules (CAMs) 1/358 130/7206 0.022099083752 ko05168 Herpes simplex infection 16/358 182/7206 0.0233866000098 ko04014 Ras signaling pathway 6/358 279/7206 0.0237137927804 ko04621 NOD-like receptor signaling pathway 2/358 157/7206 0.0246552753613 ko04120 Ubiquitin mediated proteolysis 13/358 138/7206 0.0262057560226 ko04060 Cytokine-cytokine receptor interaction 3/358 191/7206 0.0262932408756 ko03013 RNA transport 15/358 166/7206 0.0271595608819 ko04115 p53 signaling pathway 8/358 74/7206 0.0296290923901 ko04912 GnRH signaling pathway 1/358 122/7206 0.0318835308902 ko04750 Inflammatory mediator regulation of TRP channels 1/358 122/7206 0.0318835308902 ko04670 Leukocyte transendothelial migration 2/358 151/7206 0.0349484379551 ko04141 Protein processing in endoplasmic reticulum 3/358 184/7206 0.0365426085611 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 4/358 26/7206 0.0376820639435 ko04914 Progesterone-mediated oocyte maturation 10/358 104/7206 0.0380522885271 ko04391 Hippo signaling pathway - fly 9/358 90/7206 0.0438847498341 ko04972 Pancreatic secretion 1/358 111/7206 0.0445994597333 ko05414 Dilated cardiomyopathy 1/358 112/7206 0.0449331139323 ko04011 MAPK signaling pathway - yeast 6/358 53/7206 0.0463179486675 ko04910 Insulin signaling pathway 3/358 172/7206 0.0488706111649