ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 19/235 80/7206 5.43531918214e-12 ko04727 GABAergic synapse 21/235 110/7206 3.55070703591e-11 ko05033 Nicotine addiction 13/235 56/7206 1.84317368054e-08 ko05032 Morphine addiction 17/235 110/7206 7.75230520197e-08 ko04724 Glutamatergic synapse 20/235 152/7206 8.65377314755e-08 ko04911 Insulin secretion 17/235 117/7206 1.95882119613e-07 ko04964 Proximal tubule bicarbonate reclamation 9/235 29/7206 2.0288349559e-07 ko04725 Cholinergic synapse 20/235 160/7206 2.04753039275e-07 ko04713 Circadian entrainment 18/235 136/7206 3.59546691841e-07 ko04080 Neuroactive ligand-receptor interaction 34/235 423/7206 7.40462593883e-07 ko04723 Retrograde endocannabinoid signaling 20/235 175/7206 8.86849014559e-07 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/235 59/7206 2.46575868342e-06 ko04728 Dopaminergic synapse 19/235 185/7206 8.30322785593e-06 ko04726 Serotonergic synapse 15/235 137/7206 3.60014765343e-05 ko04960 Aldosterone-regulated sodium reabsorption 8/235 41/7206 4.27361621489e-05 ko04024 cAMP signaling pathway 22/235 279/7206 0.000103179468131 ko04970 Salivary secretion 11/235 95/7206 0.000244463987407 ko04972 Pancreatic secretion 12/235 111/7206 0.000247005987467 ko04971 Gastric acid secretion 11/235 98/7206 0.00032189869706 ko04720 Long-term potentiation 11/235 99/7206 0.000351911522748 ko04015 Rap1 signaling pathway 21/235 278/7206 0.000352737541004 ko05110 Vibrio cholerae infection 8/235 63/7206 0.000933903050316 ko04261 Adrenergic signaling in cardiomyocytes 16/235 205/7206 0.00103071185701 ko04976 Bile secretion 9/235 80/7206 0.00110381638876 ko04020 Calcium signaling pathway 19/235 265/7206 0.00113109674014 ko04966 Collecting duct acid secretion 5/235 26/7206 0.00132634311898 ko04978 Mineral absorption 6/235 40/7206 0.00170856558081 ko04973 Carbohydrate digestion and absorption 6/235 42/7206 0.00221169387209 ko05031 Amphetamine addiction 9/235 91/7206 0.00273686565708 ko04070 Phosphatidylinositol signaling system 10/235 112/7206 0.0034512238269 ko04730 Long-term depression 8/235 78/7206 0.00372068205211 ko04072 Phospholipase D signaling pathway 14/235 197/7206 0.00626789862087 ko04918 Thyroid hormone synthesis 8/235 86/7206 0.00674264304497 ko04919 Thyroid hormone signaling pathway 11/235 143/7206 0.00687645167183 ko04745 Phototransduction - fly 5/235 38/7206 0.00736826841125 ko04540 Gap junction 10/235 128/7206 0.00880696594227 ko04921 Oxytocin signaling pathway 14/235 209/7206 0.0091139447025 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/235 14/7206 0.00954879429873 ko02024 Quorum sensing 3/235 15/7206 0.0116527012159 ko04360 Axon guidance 15/235 233/7206 0.0125528128143 ko04742 Taste transduction 6/235 61/7206 0.0140278645654 ko04260 Cardiac muscle contraction 8/235 98/7206 0.0143510468235 ko05230 Central carbon metabolism in cancer 7/235 81/7206 0.0161052122266 ko04940 Type I diabetes mellitus 4/235 32/7206 0.019361444946 ko04925 Aldosterone synthesis and secretion 8/235 105/7206 0.0209706227971 ko04924 Renin secretion 7/235 86/7206 0.0217266369268 ko04010 MAPK signaling pathway 18/235 321/7206 0.022951912292 ko04014 Ras signaling pathway 16/235 279/7206 0.0244574159897 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/235 92/7206 0.0301129295587 ko05030 Cocaine addiction 6/235 73/7206 0.0312293577666 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/235 1/7206 0.0326117124619 ko05014 Amyotrophic lateral sclerosis (ALS) 6/235 74/7206 0.0330948733937 ko00250 Alanine, aspartate and glutamate metabolism 4/235 38/7206 0.034182117541 ko04974 Protein digestion and absorption 7/235 96/7206 0.0367780185007 ko04071 Sphingolipid signaling pathway 10/235 162/7206 0.0431005579888 ko03013 RNA transport 1/235 166/7206 0.0452526364972 ko05164 Influenza A 1/235 167/7206 0.0453237463221