ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 52/975 152/7206 4.43676666358e-11 ko04080 Neuroactive ligand-receptor interaction 105/975 423/7206 1.55009797984e-10 ko04713 Circadian entrainment 44/975 136/7206 1.22853339309e-08 ko03040 Spliceosome 1/975 145/7206 2.28975315719e-08 ko04020 Calcium signaling pathway 69/975 265/7206 3.72477562131e-08 ko04024 cAMP signaling pathway 69/975 279/7206 2.59524797145e-07 ko05033 Nicotine addiction 23/975 56/7206 3.02623043919e-07 ko03010 Ribosome 1/975 129/7206 3.05127174721e-07 ko04911 Insulin secretion 37/975 117/7206 3.28480883336e-07 ko04921 Oxytocin signaling pathway 55/975 209/7206 5.45099914067e-07 ko04070 Phosphatidylinositol signaling system 35/975 112/7206 9.157256633e-07 ko04727 GABAergic synapse 34/975 110/7206 1.69710331429e-06 ko04725 Cholinergic synapse 44/975 160/7206 3.04288132615e-06 ko04726 Serotonergic synapse 39/975 137/7206 3.26683008137e-06 ko03013 RNA transport 5/975 166/7206 5.27328583643e-06 ko05032 Morphine addiction 33/975 110/7206 6.54890448394e-06 ko04728 Dopaminergic synapse 47/975 185/7206 1.04176563763e-05 ko04110 Cell cycle 4/975 145/7206 1.26321087379e-05 ko05031 Amphetamine addiction 28/975 91/7206 1.61390613962e-05 ko04022 cGMP-PKG signaling pathway 52/975 216/7206 2.68682898653e-05 ko04072 Phospholipase D signaling pathway 48/975 197/7206 3.05196452554e-05 ko05322 Systemic lupus erythematosus 5/975 151/7206 3.25933191986e-05 ko05203 Viral carcinogenesis 16/975 277/7206 3.28327169444e-05 ko04720 Long-term potentiation 29/975 99/7206 3.74592581946e-05 ko04925 Aldosterone synthesis and secretion 30/975 105/7206 3.96589364968e-05 ko04971 Gastric acid secretion 28/975 98/7206 7.46575395054e-05 ko04730 Long-term depression 23/975 78/7206 0.000181849501495 ko03008 Ribosome biogenesis in eukaryotes 1/975 79/7206 0.000203528771623 ko04745 Phototransduction - fly 14/975 38/7206 0.00025716870808 ko04710 Circadian rhythm 15/975 43/7206 0.000313085042579 ko04970 Salivary secretion 26/975 95/7206 0.000369566491844 ko04721 Synaptic vesicle cycle 23/975 80/7206 0.000372055702293 ko04744 Phototransduction 13/975 36/7206 0.000533171450119 ko04514 Cell adhesion molecules (CAMs) 32/975 130/7206 0.000631870312385 ko04723 Retrograde endocannabinoid signaling 39/975 175/7206 0.00155089762463 ko04750 Inflammatory mediator regulation of TRP channels 29/975 122/7206 0.0019050081152 ko04014 Ras signaling pathway 56/975 279/7206 0.00226643108039 ko05224 Breast cancer 11/975 174/7206 0.00331773564028 ko04964 Proximal tubule bicarbonate reclamation 10/975 29/7206 0.00344108357109 ko04922 Glucagon signaling pathway 29/975 128/7206 0.00395034053726 ko00520 Amino sugar and nucleotide sugar metabolism 1/975 55/7206 0.00505394952867 ko03015 mRNA surveillance pathway 4/975 93/7206 0.00553168063562 ko04924 Renin secretion 21/975 86/7206 0.00618020937362 ko05169 Epstein-Barr virus infection 15/975 206/7206 0.00685794972222 ko04141 Protein processing in endoplasmic reticulum 13/975 184/7206 0.00834972100241 ko00965 Betalain biosynthesis 3/975 4/7206 0.00888165168689 ko00140 Steroid hormone biosynthesis 12/975 41/7206 0.00896185429602 ko04960 Aldosterone-regulated sodium reabsorption 12/975 41/7206 0.00896185429602 ko04015 Rap1 signaling pathway 53/975 278/7206 0.00919270215228 ko05231 Choline metabolism in cancer 29/975 134/7206 0.0100556361444 ko04371 Apelin signaling pathway 36/975 177/7206 0.0102219184212 ko04972 Pancreatic secretion 25/975 111/7206 0.0109016704623 ko00562 Inositol phosphate metabolism 21/975 89/7206 0.0113745691535 ko04270 Vascular smooth muscle contraction 32/975 154/7206 0.0118390574736 ko00120 Primary bile acid biosynthesis 7/975 20/7206 0.0126949124649 ko04060 Cytokine-cytokine receptor interaction 38/975 191/7206 0.0131897984923 ko04137 Mitophagy - animal 19/975 82/7206 0.0145519095365 ko05016 Huntington's disease 17/975 215/7206 0.0146045185552 ko04550 Signaling pathways regulating pluripotency of stem cells 12/975 165/7206 0.0152129569232 ko04650 Natural killer cell mediated cytotoxicity 22/975 97/7206 0.0154987944651 ko03420 Nucleotide excision repair 1/975 46/7206 0.0164863921925 ko04261 Adrenergic signaling in cardiomyocytes 40/975 205/7206 0.0166050188582 ko00564 Glycerophospholipid metabolism 22/975 99/7206 0.0168527525663 ko04966 Collecting duct acid secretion 8/975 26/7206 0.0180045578645 ko04360 Axon guidance 44/975 233/7206 0.0191321066161 ko04113 Meiosis - yeast 3/975 70/7206 0.0208591230487 ko04711 Circadian rhythm - fly 5/975 13/7206 0.0226068684215 ko05030 Cocaine addiction 17/975 73/7206 0.0233845226909 ko03022 Basal transcription factors 1/975 44/7206 0.0246561549541 ko04626 Plant-pathogen interaction 6/975 18/7206 0.0264551429361 ko03050 Proteasome 2/975 54/7206 0.0278151221542 ko04111 Cell cycle - yeast 5/975 90/7206 0.0281934455368 ko05217 Basal cell carcinoma 3/975 68/7206 0.0301033972993 ko04976 Bile secretion 18/975 80/7206 0.0304723636814 ko04666 Fc gamma R-mediated phagocytosis 25/975 122/7206 0.0315660275897 ko04120 Ubiquitin mediated proteolysis 10/975 138/7206 0.0315725692616 ko00592 alpha-Linolenic acid metabolism 6/975 19/7206 0.0343646158549 ko02010 ABC transporters 10/975 39/7206 0.0344831211237 ko00350 Tyrosine metabolism 9/975 33/7206 0.035501869021 ko04540 Gap junction 26/975 128/7206 0.0356064879421