ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 60/292 423/7206 1.76824753136e-18 ko04724 Glutamatergic synapse 27/292 152/7206 5.22889736297e-11 ko05033 Nicotine addiction 16/292 56/7206 3.38050634404e-10 ko04728 Dopaminergic synapse 27/292 185/7206 4.98322063518e-09 ko04727 GABAergic synapse 20/292 110/7206 1.20635075702e-08 ko05032 Morphine addiction 19/292 110/7206 6.71504068896e-08 ko04723 Retrograde endocannabinoid signaling 23/292 175/7206 5.04912068281e-07 ko04725 Cholinergic synapse 20/292 160/7206 6.26768980971e-06 ko04024 cAMP signaling pathway 28/292 279/7206 7.2491148589e-06 ko04713 Circadian entrainment 18/292 136/7206 8.23623223936e-06 ko04721 Synaptic vesicle cycle 13/292 80/7206 1.6639082785e-05 ko04972 Pancreatic secretion 15/292 111/7206 3.67851626424e-05 ko04730 Long-term depression 12/292 78/7206 6.16560045129e-05 ko04911 Insulin secretion 15/292 117/7206 6.86032926107e-05 ko04010 MAPK signaling pathway 28/292 321/7206 0.00011360831172 ko05030 Cocaine addiction 11/292 73/7206 0.000151242001534 ko04970 Salivary secretion 12/292 95/7206 0.000419363753251 ko04961 Endocrine and other factor-regulated calcium reabsorption 9/292 59/7206 0.000549049127096 ko04924 Renin secretion 11/292 86/7206 0.000651281611161 ko05014 Amyotrophic lateral sclerosis (ALS) 10/292 74/7206 0.00073650135556 ko04261 Adrenergic signaling in cardiomyocytes 19/292 205/7206 0.0007984181368 ko04964 Proximal tubule bicarbonate reclamation 6/292 29/7206 0.000907402291231 ko04925 Aldosterone synthesis and secretion 12/292 105/7206 0.00104373880031 ko05031 Amphetamine addiction 11/292 91/7206 0.00105286733428 ko04976 Bile secretion 10/292 80/7206 0.00136276587377 ko04540 Gap junction 13/292 128/7206 0.00195776867501 ko05169 Epstein-Barr virus infection 1/292 206/7206 0.00342737070328 ko04020 Calcium signaling pathway 21/292 265/7206 0.00353399091167 ko04726 Serotonergic synapse 13/292 137/7206 0.00357193060069 ko04978 Mineral absorption 6/292 40/7206 0.00504657775116 ko04971 Gastric acid secretion 10/292 98/7206 0.00611695524279 ko04921 Oxytocin signaling pathway 17/292 209/7206 0.00626554460517 ko05142 Chagas disease (American trypanosomiasis) 12/292 130/7206 0.00627716080999 ko04141 Protein processing in endoplasmic reticulum 1/292 184/7206 0.00716299099338 ko05152 Tuberculosis 1/292 187/7206 0.00728249645016 ko05203 Viral carcinogenesis 3/292 277/7206 0.007284358176 ko04217 Necroptosis 1/292 178/7206 0.0106369751662 ko04915 Estrogen signaling pathway 12/292 131/7206 0.0108807691553 ko04742 Taste transduction 7/292 61/7206 0.0111730122085 ko04015 Rap1 signaling pathway 20/292 278/7206 0.011953475049 ko03013 RNA transport 1/292 166/7206 0.0151427777227 ko04072 Phospholipase D signaling pathway 15/292 197/7206 0.01616936973 ko04666 Fc gamma R-mediated phagocytosis 11/292 122/7206 0.0164779478159 ko04360 Axon guidance 17/292 233/7206 0.0168580958282 ko04022 cGMP-PKG signaling pathway 16/292 216/7206 0.0203997357794 ko04514 Cell adhesion molecules (CAMs) 11/292 130/7206 0.0204924939152 ko05210 Colorectal cancer 8/292 86/7206 0.0227080826586 ko04060 Cytokine-cytokine receptor interaction 2/292 191/7206 0.0249404258398 ko03040 Spliceosome 1/292 145/7206 0.0313316747078 ko04142 Lysosome 1/292 151/7206 0.0329031281631 ko05322 Systemic lupus erythematosus 1/292 151/7206 0.0329031281631 ko04614 Renin-angiotensin system 3/292 18/7206 0.0342204327645 ko05168 Herpes simplex infection 2/292 182/7206 0.0349976803321 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 7/292 79/7206 0.0402952665889 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/292 1/7206 0.0405217873995