ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	207/1283	423/7206	3.7094264811e-52
ko04724	Glutamatergic synapse	92/1283	152/7206	1.6510103609e-32
ko04713	Circadian entrainment	80/1283	136/7206	3.53079177498e-27
ko05032	Morphine addiction	69/1283	110/7206	6.14528725372e-26
ko05033	Nicotine addiction	46/1283	56/7206	9.53561456384e-26
ko04727	GABAergic synapse	67/1283	110/7206	3.78010904267e-24
ko04728	Dopaminergic synapse	88/1283	185/7206	4.21647794872e-21
ko04725	Cholinergic synapse	80/1283	160/7206	5.48937523132e-21
ko04721	Synaptic vesicle cycle	52/1283	80/7206	7.34796870806e-21
ko04020	Calcium signaling pathway	107/1283	265/7206	1.53085880925e-18
ko04024	cAMP signaling pathway	109/1283	279/7206	1.47973530069e-17
ko04723	Retrograde endocannabinoid signaling	79/1283	175/7206	2.32836659066e-17
ko04911	Insulin secretion	60/1283	117/7206	1.06545240459e-16
ko04726	Serotonergic synapse	65/1283	137/7206	8.3530919614e-16
ko04742	Taste transduction	39/1283	61/7206	1.36720636561e-15
ko04921	Oxytocin signaling pathway	84/1283	209/7206	1.11143209799e-14
ko04970	Salivary secretion	48/1283	95/7206	2.70232120078e-13
ko04744	Phototransduction	26/1283	36/7206	1.06328921964e-12
ko03040	Spliceosome	1/1283	145/7206	1.58605182741e-11
ko05031	Amphetamine addiction	44/1283	91/7206	1.8450261539e-11
ko04261	Adrenergic signaling in cardiomyocytes	76/1283	205/7206	2.73292904684e-11
ko04720	Long-term potentiation	46/1283	99/7206	3.66359442853e-11
ko04740	Olfactory transduction	37/1283	80/7206	3.60733164962e-09
ko04022	cGMP-PKG signaling pathway	74/1283	216/7206	3.67469540945e-09
ko04925	Aldosterone synthesis and secretion	43/1283	105/7206	2.00977519069e-08
ko04971	Gastric acid secretion	41/1283	98/7206	2.36135115853e-08
ko04360	Axon guidance	76/1283	233/7206	2.55959497148e-08
ko05203	Viral carcinogenesis	19/1283	277/7206	1.34476601376e-07
ko03013	RNA transport	7/1283	166/7206	1.6569348844e-07
ko04540	Gap junction	47/1283	128/7206	2.69235616991e-07
ko05168	Herpes simplex infection	9/1283	182/7206	3.40690966528e-07
ko05322	Systemic lupus erythematosus	6/1283	151/7206	4.26727432785e-07
ko05030	Cocaine addiction	31/1283	73/7206	7.13997002961e-07
ko04730	Long-term depression	32/1283	78/7206	1.40700615644e-06
ko04972	Pancreatic secretion	41/1283	111/7206	1.9170607646e-06
ko04070	Phosphatidylinositol signaling system	40/1283	112/7206	4.70418451036e-06
ko04924	Renin secretion	33/1283	86/7206	5.62412229061e-06
ko04966	Collecting duct acid secretion	15/1283	26/7206	5.71062491956e-06
ko04010	MAPK signaling pathway	89/1283	321/7206	6.54615257531e-06
ko04014	Ras signaling pathway	79/1283	279/7206	9.71394150137e-06
ko04060	Cytokine-cytokine receptor interaction	13/1283	191/7206	1.28577700296e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1283	74/7206	1.89887306616e-05
ko04750	Inflammatory mediator regulation of TRP channels	41/1283	122/7206	2.13966360094e-05
ko04514	Cell adhesion molecules (CAMs)	43/1283	130/7206	2.25077507917e-05
ko04964	Proximal tubule bicarbonate reclamation	15/1283	29/7206	3.35146005647e-05
ko04141	Protein processing in endoplasmic reticulum	13/1283	184/7206	3.38544203922e-05
ko05164	Influenza A	11/1283	167/7206	3.41826114899e-05
ko04072	Phospholipase D signaling pathway	58/1283	197/7206	4.34747136981e-05
ko04120	Ubiquitin mediated proteolysis	8/1283	138/7206	4.34915667881e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1283	79/7206	4.47574269151e-05
ko04621	NOD-like receptor signaling pathway	10/1283	157/7206	4.81554819419e-05
ko04110	Cell cycle	9/1283	145/7206	6.39467156099e-05
ko04976	Bile secretion	29/1283	80/7206	8.53459443893e-05
ko04745	Phototransduction - fly	17/1283	38/7206	0.000107529868004
ko04923	Regulation of lipolysis in adipocytes	28/1283	77/7206	0.00011712345361
ko05110	Vibrio cholerae infection	24/1283	63/7206	0.000166518719878
ko05414	Dilated cardiomyopathy	36/1283	112/7206	0.000241257199676
ko05169	Epstein-Barr virus infection	18/1283	206/7206	0.000283677823248
ko04371	Apelin signaling pathway	51/1283	177/7206	0.00029784238375
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1283	59/7206	0.000417179531595
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1283	79/7206	0.000505605168618
ko05140	Leishmaniasis	3/1283	75/7206	0.000657810168655
ko04915	Estrogen signaling pathway	39/1283	131/7206	0.000727039718945
ko04260	Cardiac muscle contraction	31/1283	98/7206	0.000767756226087
ko04146	Peroxisome	5/1283	89/7206	0.00117142234302
ko04610	Complement and coagulation cascades	4/1283	79/7206	0.00158778243002
ko05162	Measles	9/1283	120/7206	0.00163337524409
ko04064	NF-kappa B signaling pathway	6/1283	96/7206	0.00174405934262
ko04626	Plant-pathogen interaction	9/1283	18/7206	0.00181529027722
ko04710	Circadian rhythm	16/1283	43/7206	0.00217630428848
ko04612	Antigen processing and presentation	4/1283	77/7206	0.00231240889862
ko00240	Pyrimidine metabolism	8/1283	110/7206	0.0023326732349
ko05205	Proteoglycans in cancer	30/1283	271/7206	0.00263526644899
ko03022	Basal transcription factors	1/1283	44/7206	0.00272274368199
ko05144	Malaria	1/1283	45/7206	0.00272577350419
ko00071	Fatty acid degradation	1/1283	45/7206	0.00272577350419
ko03420	Nucleotide excision repair	1/1283	46/7206	0.00286060229455
ko00310	Lysine degradation	4/1283	73/7206	0.00316316367038
ko04270	Vascular smooth muscle contraction	42/1283	154/7206	0.00376839529597
ko00480	Glutathione metabolism	2/1283	55/7206	0.00379776281487
ko04622	RIG-I-like receptor signaling pathway	3/1283	62/7206	0.0041753436626
ko05161	Hepatitis B	17/1283	173/7206	0.00461029383273
ko05133	Pertussis	6/1283	87/7206	0.00462455747375
ko04015	Rap1 signaling pathway	68/1283	278/7206	0.00496691415289
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1283	14/7206	0.00597063253
ko05145	Toxoplasmosis	11/1283	126/7206	0.00644558506053
ko04922	Glucagon signaling pathway	35/1283	128/7206	0.00695479121654
ko04916	Melanogenesis	38/1283	142/7206	0.00747078807373
ko00562	Inositol phosphate metabolism	26/1283	89/7206	0.00754819256398
ko05131	Shigellosis	6/1283	82/7206	0.00882091466405
ko03018	RNA degradation	6/1283	84/7206	0.0090140174381
ko04918	Thyroid hormone synthesis	25/1283	86/7206	0.00994425664314
ko04912	GnRH signaling pathway	33/1283	122/7206	0.0115573841185
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1283	100/7206	0.0116544116781
ko04960	Aldosterone-regulated sodium reabsorption	14/1283	41/7206	0.011987412703
ko04930	Type II diabetes mellitus	17/1283	54/7206	0.0121838120549
ko04214	Apoptosis - fly	5/1283	72/7206	0.0125671818024
ko05321	Inflammatory bowel disease (IBD)	3/1283	56/7206	0.0127045171977
ko04973	Carbohydrate digestion and absorption	14/1283	42/7206	0.0137879673455
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1283	182/7206	0.0138410532925
ko04658	Th1 and Th2 cell differentiation	8/1283	96/7206	0.0147184138723
ko04630	Jak-STAT signaling pathway	13/1283	132/7206	0.0153230166362
ko04657	IL-17 signaling pathway	7/1283	87/7206	0.0156519086621
ko05231	Choline metabolism in cancer	35/1283	134/7206	0.016059488765
ko00590	Arachidonic acid metabolism	3/1283	52/7206	0.0177289440823
ko00330	Arginine and proline metabolism	4/1283	61/7206	0.0178444418717
ko04330	Notch signaling pathway	4/1283	62/7206	0.0181642969767
ko00280	Valine, leucine and isoleucine degradation	3/1283	54/7206	0.0184215655004
ko05166	HTLV-I infection	37/1283	292/7206	0.0189267270407
ko04217	Necroptosis	20/1283	178/7206	0.021942661475
ko04213	Longevity regulating pathway - multiple species	24/1283	86/7206	0.0220228404117
ko00380	Tryptophan metabolism	3/1283	50/7206	0.0251928056165
ko05214	Glioma	22/1283	79/7206	0.0255919067612
ko04210	Apoptosis	21/1283	180/7206	0.0295583119608
ko04115	p53 signaling pathway	6/1283	74/7206	0.0309847745679
ko05340	Primary immunodeficiency	1/1283	30/7206	0.0316850535887
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1283	40/7206	0.0356690897671
ko05219	Bladder cancer	3/1283	48/7206	0.0358070614424
ko04113	Meiosis - yeast	6/1283	70/7206	0.0410455048844
ko04114	Oocyte meiosis	34/1283	139/7206	0.0436193284866
ko04620	Toll-like receptor signaling pathway	10/1283	100/7206	0.0470066187599
ko05320	Autoimmune thyroid disease	1/1283	29/7206	0.0480817861597
ko01524	Platinum drug resistance	7/1283	76/7206	0.0496850439238