ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	191/1134	423/7206	4.86151914074e-50
ko04724	Glutamatergic synapse	87/1134	152/7206	2.05193529374e-32
ko05033	Nicotine addiction	48/1134	56/7206	4.73546444144e-31
ko05032	Morphine addiction	68/1134	110/7206	2.43442248091e-28
ko04713	Circadian entrainment	74/1134	136/7206	8.69010820839e-26
ko04727	GABAergic synapse	64/1134	110/7206	1.25623156611e-24
ko04721	Synaptic vesicle cycle	50/1134	80/7206	1.97258937015e-21
ko04728	Dopaminergic synapse	82/1134	185/7206	7.76439814358e-21
ko04723	Retrograde endocannabinoid signaling	78/1134	175/7206	4.77330613072e-20
ko04725	Cholinergic synapse	71/1134	160/7206	3.27115410494e-18
ko04024	cAMP signaling pathway	102/1134	279/7206	4.41812174559e-18
ko04911	Insulin secretion	54/1134	117/7206	5.01524012969e-15
ko04742	Taste transduction	36/1134	61/7206	1.19099261265e-14
ko04726	Serotonergic synapse	58/1134	137/7206	5.5174690103e-14
ko04020	Calcium signaling pathway	89/1134	265/7206	2.12056445701e-13
ko04744	Phototransduction	24/1134	36/7206	7.89870179005e-12
ko04921	Oxytocin signaling pathway	72/1134	209/7206	1.26603666888e-11
ko05031	Amphetamine addiction	41/1134	91/7206	2.6636325083e-11
ko04261	Adrenergic signaling in cardiomyocytes	70/1134	205/7206	3.71835483472e-11
ko03040	Spliceosome	1/1134	145/7206	5.23253141037e-10
ko04720	Long-term potentiation	40/1134	99/7206	2.5354095298e-09
ko05030	Cocaine addiction	32/1134	73/7206	9.47436253649e-09
ko04970	Salivary secretion	36/1134	95/7206	1.89773333353e-07
ko04925	Aldosterone synthesis and secretion	38/1134	105/7206	2.19443509764e-07
ko04360	Axon guidance	67/1134	233/7206	3.22193876342e-07
ko05203	Viral carcinogenesis	16/1134	277/7206	3.3218836085e-07
ko05322	Systemic lupus erythematosus	5/1134	151/7206	1.34308857058e-06
ko04060	Cytokine-cytokine receptor interaction	9/1134	191/7206	2.5646078696e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1134	74/7206	2.99743053097e-06
ko03013	RNA transport	7/1134	166/7206	4.13605882104e-06
ko05164	Influenza A	7/1134	167/7206	4.24114525742e-06
ko05168	Herpes simplex infection	9/1134	182/7206	7.22598959793e-06
ko04966	Collecting duct acid secretion	14/1134	26/7206	7.88923374119e-06
ko04971	Gastric acid secretion	33/1134	98/7206	8.84701296767e-06
ko04621	NOD-like receptor signaling pathway	7/1134	157/7206	1.20500675779e-05
ko04141	Protein processing in endoplasmic reticulum	10/1134	184/7206	2.09877949969e-05
ko04022	cGMP-PKG signaling pathway	58/1134	216/7206	2.39396152731e-05
ko04010	MAPK signaling pathway	79/1134	321/7206	2.80717065303e-05
ko04972	Pancreatic secretion	35/1134	111/7206	3.01607566626e-05
ko04070	Phosphatidylinositol signaling system	35/1134	112/7206	3.42169381454e-05
ko04514	Cell adhesion molecules (CAMs)	39/1134	130/7206	4.27777708965e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1134	79/7206	5.8494725895e-05
ko04072	Phospholipase D signaling pathway	53/1134	197/7206	5.89970669924e-05
ko05110	Vibrio cholerae infection	23/1134	63/7206	6.39521276219e-05
ko04740	Olfactory transduction	27/1134	80/7206	6.67249801245e-05
ko04120	Ubiquitin mediated proteolysis	7/1134	138/7206	0.000137357183753
ko04064	NF-kappa B signaling pathway	3/1134	96/7206	0.000174212315636
ko04110	Cell cycle	8/1134	145/7206	0.000200433386031
ko05414	Dilated cardiomyopathy	33/1134	112/7206	0.000202671172188
ko04730	Long-term depression	25/1134	78/7206	0.000261868161855
ko04610	Complement and coagulation cascades	2/1134	79/7206	0.000265909054829
ko03008	Ribosome biogenesis in eukaryotes	2/1134	79/7206	0.000265909054829
ko05169	Epstein-Barr virus infection	15/1134	206/7206	0.000306722934977
ko04745	Phototransduction - fly	15/1134	38/7206	0.000351614958405
ko04260	Cardiac muscle contraction	29/1134	98/7206	0.00063629080987
ko04923	Regulation of lipolysis in adipocytes	24/1134	77/7206	0.000711780821022
ko04924	Renin secretion	26/1134	86/7206	0.000814492943248
ko05205	Proteoglycans in cancer	24/1134	271/7206	0.00088578864627
ko04915	Estrogen signaling pathway	35/1134	131/7206	0.0010129239471
ko00520	Amino sugar and nucleotide sugar metabolism	1/1134	55/7206	0.00134548716977
ko04540	Gap junction	34/1134	128/7206	0.00135951366553
ko05162	Measles	7/1134	120/7206	0.00140748261161
ko05161	Hepatitis B	13/1134	173/7206	0.00146384816299
ko05140	Leishmaniasis	3/1134	75/7206	0.00224257401892
ko04612	Antigen processing and presentation	3/1134	77/7206	0.00232317744951
ko04014	Ras signaling pathway	63/1134	279/7206	0.00241714369473
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1134	14/7206	0.00290381197658
ko04976	Bile secretion	23/1134	80/7206	0.0029065482668
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1134	59/7206	0.0036534587981
ko04510	Focal adhesion	22/1134	240/7206	0.00373857248201
ko04210	Apoptosis	15/1134	180/7206	0.00484530565645
ko04146	Peroxisome	5/1134	89/7206	0.00512408303813
ko04710	Circadian rhythm	14/1134	43/7206	0.00526423677159
ko04750	Inflammatory mediator regulation of TRP channels	31/1134	122/7206	0.00539569956488
ko05144	Malaria	1/1134	45/7206	0.00681397251372
ko00071	Fatty acid degradation	1/1134	45/7206	0.00681397251372
ko03420	Nucleotide excision repair	1/1134	46/7206	0.00694993448242
ko04658	Th1 and Th2 cell differentiation	6/1134	96/7206	0.00701647400451
ko05133	Pertussis	5/1134	87/7206	0.00714000581407
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1134	100/7206	0.00794132315239
ko04930	Type II diabetes mellitus	16/1134	54/7206	0.00823294513654
ko00480	Glutathione metabolism	2/1134	55/7206	0.0085282758
ko05321	Inflammatory bowel disease (IBD)	2/1134	56/7206	0.00868629502968
ko03022	Basal transcription factors	1/1134	44/7206	0.0106857973566
ko00240	Pyrimidine metabolism	8/1134	110/7206	0.0116551488143
ko00562	Inositol phosphate metabolism	23/1134	89/7206	0.0122785971975
ko00590	Arachidonic acid metabolism	2/1134	52/7206	0.0123918841956
ko05145	Toxoplasmosis	10/1134	126/7206	0.0131162076884
ko04622	RIG-I-like receptor signaling pathway	3/1134	62/7206	0.0134740965855
ko05131	Shigellosis	5/1134	82/7206	0.0137331355969
ko00310	Lysine degradation	4/1134	73/7206	0.0141141158258
ko04626	Plant-pathogen interaction	7/1134	18/7206	0.0151536766109
ko04630	Jak-STAT signaling pathway	11/1134	132/7206	0.0155836016622
ko04964	Proximal tubule bicarbonate reclamation	10/1134	29/7206	0.0171442674653
ko04218	Cellular senescence	17/1134	177/7206	0.0212898310503
ko04217	Necroptosis	17/1134	178/7206	0.0213671853234
ko05016	Huntington's disease	22/1134	215/7206	0.0223994523432
ko04912	GnRH signaling pathway	29/1134	122/7206	0.0230065947289
ko00630	Glyoxylate and dicarboxylate metabolism	1/1134	38/7206	0.0230118988239
ko03410	Base excision repair	1/1134	38/7206	0.0230118988239
ko04657	IL-17 signaling pathway	6/1134	87/7206	0.0248279210433
ko05215	Prostate cancer	9/1134	111/7206	0.0248767593438
ko01524	Platinum drug resistance	5/1134	76/7206	0.0256521614085
ko05219	Bladder cancer	2/1134	48/7206	0.0264210840285
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1134	182/7206	0.0297570500804
ko04933	AGE-RAGE signaling pathway in diabetic complications	12/1134	135/7206	0.0307514108675
ko04810	Regulation of actin cytoskeleton	29/1134	264/7206	0.0310487320958
ko05202	Transcriptional misregulation in cancer	19/1134	188/7206	0.0325669575421
ko05166	HTLV-I infection	33/1134	292/7206	0.0328220639762
ko03018	RNA degradation	6/1134	84/7206	0.0332129764306
ko00860	Porphyrin and chlorophyll metabolism	1/1134	34/7206	0.0337321409225
ko00500	Starch and sucrose metabolism	1/1134	35/7206	0.0339071261889
ko04115	p53 signaling pathway	5/1134	74/7206	0.0353153021718
ko04918	Thyroid hormone synthesis	21/1134	86/7206	0.0355832431831
ko04620	Toll-like receptor signaling pathway	8/1134	100/7206	0.0366475467214
ko04922	Glucagon signaling pathway	29/1134	128/7206	0.0366993877845
ko04640	Hematopoietic cell lineage	4/1134	64/7206	0.037033361838
ko00280	Valine, leucine and isoleucine degradation	3/1134	54/7206	0.0379531197453
ko05222	Small cell lung cancer	7/1134	89/7206	0.0396921018159
ko05231	Choline metabolism in cancer	30/1134	134/7206	0.040926394279
ko04711	Circadian rhythm - fly	5/1134	13/7206	0.0409809136876
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1134	92/7206	0.0420408212614
ko04371	Apelin signaling pathway	38/1134	177/7206	0.0462052387872
ko04214	Apoptosis - fly	5/1134	72/7206	0.0486874901092