ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	187/1135	423/7206	3.5068651794e-47
ko04724	Glutamatergic synapse	83/1135	152/7206	6.14859147567e-29
ko05033	Nicotine addiction	46/1135	56/7206	3.87537734508e-28
ko05032	Morphine addiction	63/1135	110/7206	1.01693175778e-23
ko04721	Synaptic vesicle cycle	52/1135	80/7206	2.14409580037e-23
ko04713	Circadian entrainment	70/1135	136/7206	1.52939635639e-22
ko04728	Dopaminergic synapse	83/1135	185/7206	1.7904703532e-21
ko04727	GABAergic synapse	60/1135	110/7206	3.69969211942e-21
ko04725	Cholinergic synapse	72/1135	160/7206	7.50688378303e-19
ko04723	Retrograde endocannabinoid signaling	73/1135	175/7206	7.52272492417e-17
ko04024	cAMP signaling pathway	98/1135	279/7206	6.26194283558e-16
ko04742	Taste transduction	37/1135	61/7206	1.49085811172e-15
ko04020	Calcium signaling pathway	91/1135	265/7206	2.5208996604e-14
ko04921	Oxytocin signaling pathway	76/1135	209/7206	1.27412004722e-13
ko04726	Serotonergic synapse	56/1135	137/7206	9.22040069654e-13
ko04911	Insulin secretion	50/1135	117/7206	2.11247473072e-12
ko04261	Adrenergic signaling in cardiomyocytes	71/1135	205/7206	1.53027683045e-11
ko04360	Axon guidance	75/1135	233/7206	1.96526146711e-10
ko03040	Spliceosome	1/1135	145/7206	5.2065900985e-10
ko05031	Amphetamine addiction	39/1135	91/7206	5.2527833827e-10
ko04970	Salivary secretion	39/1135	95/7206	2.38723189108e-09
ko04720	Long-term potentiation	40/1135	99/7206	2.60345272373e-09
ko04744	Phototransduction	21/1135	36/7206	6.01802229108e-09
ko05203	Viral carcinogenesis	15/1135	277/7206	1.22687285587e-07
ko05168	Herpes simplex infection	7/1135	182/7206	4.66096978691e-07
ko04060	Cytokine-cytokine receptor interaction	8/1135	191/7206	5.48135190388e-07
ko03013	RNA transport	6/1135	166/7206	7.98901354525e-07
ko05164	Influenza A	6/1135	167/7206	8.05317608191e-07
ko04925	Aldosterone synthesis and secretion	37/1135	105/7206	9.34324597385e-07
ko04971	Gastric acid secretion	35/1135	98/7206	9.57889121592e-07
ko04966	Collecting duct acid secretion	15/1135	26/7206	1.15288303196e-06
ko04924	Renin secretion	32/1135	86/7206	1.30090918303e-06
ko04010	MAPK signaling pathway	83/1135	321/7206	2.03726097301e-06
ko05030	Cocaine addiction	28/1135	73/7206	2.22606215711e-06
ko04740	Olfactory transduction	30/1135	80/7206	2.71798404064e-06
ko04022	cGMP-PKG signaling pathway	60/1135	216/7206	6.19607886634e-06
ko05322	Systemic lupus erythematosus	6/1135	151/7206	7.35413471373e-06
ko04120	Ubiquitin mediated proteolysis	5/1135	138/7206	8.76952274473e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1135	79/7206	1.43700118069e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1135	74/7206	3.45939364015e-05
ko04621	NOD-like receptor signaling pathway	8/1135	157/7206	5.2771762152e-05
ko04540	Gap junction	38/1135	128/7206	6.5480509807e-05
ko04260	Cardiac muscle contraction	31/1135	98/7206	6.88552946831e-05
ko04141	Protein processing in endoplasmic reticulum	11/1135	184/7206	8.01792946201e-05
ko04514	Cell adhesion molecules (CAMs)	38/1135	130/7206	8.13186280102e-05
ko04745	Phototransduction - fly	16/1135	38/7206	9.14419211811e-05
ko05169	Epstein-Barr virus infection	14/1135	206/7206	0.000134247172257
ko05414	Dilated cardiomyopathy	33/1135	112/7206	0.000204919892014
ko04730	Long-term depression	25/1135	78/7206	0.000264983173583
ko03008	Ribosome biogenesis in eukaryotes	2/1135	79/7206	0.00026585648063
ko05161	Hepatitis B	11/1135	173/7206	0.000280839799672
ko04014	Ras signaling pathway	67/1135	279/7206	0.000284098366186
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1135	14/7206	0.00045549384666
ko05205	Proteoglycans in cancer	23/1135	271/7206	0.000460279220198
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1135	59/7206	0.000477187857058
ko04972	Pancreatic secretion	32/1135	111/7206	0.000513941571639
ko04064	NF-kappa B signaling pathway	4/1135	96/7206	0.000599933009937
ko05140	Leishmaniasis	2/1135	75/7206	0.000607630663606
ko05110	Vibrio cholerae infection	21/1135	63/7206	0.000662890012166
ko04976	Bile secretion	24/1135	80/7206	0.00107164175126
ko00480	Glutathione metabolism	1/1135	55/7206	0.00134352311482
ko05162	Measles	7/1135	120/7206	0.00140824132546
ko04110	Cell cycle	10/1135	145/7206	0.00175831673056
ko04146	Peroxisome	4/1135	89/7206	0.00178569512961
ko04612	Antigen processing and presentation	3/1135	77/7206	0.00232813217105
ko04070	Phosphatidylinositol signaling system	30/1135	112/7206	0.00241395099295
ko04750	Inflammatory mediator regulation of TRP channels	32/1135	122/7206	0.00246404196893
ko04640	Hematopoietic cell lineage	2/1135	64/7206	0.002792899881
ko04964	Proximal tubule bicarbonate reclamation	11/1135	29/7206	0.00313785210964
ko04371	Apelin signaling pathway	43/1135	177/7206	0.00320101296307
ko04214	Apoptosis - fly	3/1135	72/7206	0.00323489596065
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1135	100/7206	0.00342958013883
ko04668	TNF signaling pathway	8/1135	120/7206	0.00352622544413
ko04626	Plant-pathogen interaction	8/1135	18/7206	0.00368149613336
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1135	182/7206	0.00369502597828
ko00330	Arginine and proline metabolism	2/1135	61/7206	0.00404602899472
ko00240	Pyrimidine metabolism	7/1135	110/7206	0.00510255579285
ko00071	Fatty acid degradation	1/1135	45/7206	0.00681067375685
ko03420	Nucleotide excision repair	1/1135	46/7206	0.00695581693728
ko04072	Phospholipase D signaling pathway	45/1135	197/7206	0.00735572513086
ko05321	Inflammatory bowel disease (IBD)	2/1135	56/7206	0.00869463505029
ko03018	RNA degradation	5/1135	84/7206	0.00986793311586
ko01524	Platinum drug resistance	4/1135	76/7206	0.0102052527142
ko04915	Estrogen signaling pathway	32/1135	131/7206	0.0103793119948
ko03022	Basal transcription factors	1/1135	44/7206	0.0107022011
ko00590	Arachidonic acid metabolism	2/1135	52/7206	0.0123838171824
ko04620	Toll-like receptor signaling pathway	7/1135	100/7206	0.0124155438025
ko00280	Valine, leucine and isoleucine degradation	2/1135	54/7206	0.0129706420318
ko05145	Toxoplasmosis	10/1135	126/7206	0.0131189738365
ko04622	RIG-I-like receptor signaling pathway	3/1135	62/7206	0.0134705360992
ko05166	HTLV-I infection	31/1135	292/7206	0.0136143396878
ko00561	Glycerolipid metabolism	3/1135	63/7206	0.0136868066053
ko05131	Shigellosis	5/1135	82/7206	0.013743516636
ko00310	Lysine degradation	4/1135	73/7206	0.0141331850168
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1135	40/7206	0.0152398155741
ko04630	Jak-STAT signaling pathway	11/1135	132/7206	0.0155767245816
ko04657	IL-17 signaling pathway	6/1135	87/7206	0.0178353521669
ko05133	Pertussis	6/1135	87/7206	0.0178353521669
ko00380	Tryptophan metabolism	2/1135	50/7206	0.0180300835277
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1135	92/7206	0.0202566392749
ko00982	Drug metabolism - cytochrome P450	1/1135	37/7206	0.0226493281142
ko04930	Type II diabetes mellitus	15/1135	54/7206	0.0226716995401
ko04658	Th1 and Th2 cell differentiation	7/1135	96/7206	0.0228212036618
ko03410	Base excision repair	1/1135	38/7206	0.0230244582467
ko05215	Prostate cancer	9/1135	111/7206	0.0248833976317
ko05219	Bladder cancer	2/1135	48/7206	0.0264416844462
ko01200	Carbon metabolism	11/1135	128/7206	0.0266054824725
ko04210	Apoptosis	18/1135	180/7206	0.0295700690976
ko04140	Autophagy - animal	16/1135	164/7206	0.0302078506169
ko04270	Vascular smooth muscle contraction	34/1135	154/7206	0.0335284845853
ko00640	Propanoate metabolism	1/1135	34/7206	0.0337095143452
ko00860	Porphyrin and chlorophyll metabolism	1/1135	34/7206	0.0337095143452
ko00500	Starch and sucrose metabolism	1/1135	35/7206	0.0339134138383
ko04115	p53 signaling pathway	5/1135	74/7206	0.0353459270166
ko05206	MicroRNAs in cancer	18/1135	177/7206	0.0367900966291
ko04217	Necroptosis	18/1135	178/7206	0.0368002494552
ko05144	Malaria	2/1135	45/7206	0.0377394800726
ko04923	Regulation of lipolysis in adipocytes	19/1135	77/7206	0.0395843057711
ko05222	Small cell lung cancer	7/1135	89/7206	0.0396903094664
ko04916	Melanogenesis	31/1135	142/7206	0.0481632070799