ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 62/755 152/7206 5.72346871936e-23 ko04721 Synaptic vesicle cycle 40/755 80/7206 4.47078727507e-19 ko05033 Nicotine addiction 33/755 56/7206 7.33524430565e-19 ko04080 Neuroactive ligand-receptor interaction 106/755 423/7206 7.52361377253e-19 ko04728 Dopaminergic synapse 59/755 185/7206 6.91662034015e-16 ko04713 Circadian entrainment 48/755 136/7206 4.72214563209e-15 ko05032 Morphine addiction 41/755 110/7206 5.8689889305e-14 ko04727 GABAergic synapse 40/755 110/7206 3.0961433873e-13 ko04723 Retrograde endocannabinoid signaling 51/755 175/7206 3.5105393719e-12 ko04024 cAMP signaling pathway 66/755 279/7206 8.86000921122e-11 ko04725 Cholinergic synapse 45/755 160/7206 2.51951133894e-10 ko04911 Insulin secretion 36/755 117/7206 1.11202816293e-09 ko04020 Calcium signaling pathway 61/755 265/7206 1.94939983117e-09 ko05031 Amphetamine addiction 30/755 91/7206 4.52946135987e-09 ko04921 Oxytocin signaling pathway 51/755 209/7206 5.53971379002e-09 ko04720 Long-term potentiation 29/755 99/7206 1.56000185745e-07 ko04261 Adrenergic signaling in cardiomyocytes 46/755 205/7206 3.71114425188e-07 ko04726 Serotonergic synapse 35/755 137/7206 5.71770413912e-07 ko04970 Salivary secretion 27/755 95/7206 8.14420288814e-07 ko03040 Spliceosome 1/755 145/7206 3.1456947069e-06 ko04514 Cell adhesion molecules (CAMs) 32/755 130/7206 3.15779503272e-06 ko04966 Collecting duct acid secretion 12/755 26/7206 3.86168039863e-06 ko04070 Phosphatidylinositol signaling system 28/755 112/7206 1.18809064176e-05 ko04022 cGMP-PKG signaling pathway 44/755 216/7206 1.26551573602e-05 ko04745 Phototransduction - fly 14/755 38/7206 1.4891456184e-05 ko03010 Ribosome 1/755 129/7206 1.55387122122e-05 ko04010 MAPK signaling pathway 58/755 321/7206 2.347140882e-05 ko05030 Cocaine addiction 20/755 73/7206 3.8979591626e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 20/755 74/7206 4.82654173355e-05 ko04014 Ras signaling pathway 51/755 279/7206 5.66566716793e-05 ko04360 Axon guidance 44/755 233/7206 0.000114006930775 ko05322 Systemic lupus erythematosus 3/755 151/7206 0.000122081812853 ko03013 RNA transport 4/755 166/7206 0.000151170335188 ko05110 Vibrio cholerae infection 17/755 63/7206 0.000179730478464 ko04060 Cytokine-cytokine receptor interaction 6/755 191/7206 0.000267135171394 ko04120 Ubiquitin mediated proteolysis 3/755 138/7206 0.000351613327229 ko05164 Influenza A 5/755 167/7206 0.000469329573533 ko04730 Long-term depression 19/755 78/7206 0.000497910285405 ko05168 Herpes simplex infection 6/755 182/7206 0.000508251833031 ko04925 Aldosterone synthesis and secretion 23/755 105/7206 0.000543281670516 ko05203 Viral carcinogenesis 13/755 277/7206 0.000621955918911 ko04971 Gastric acid secretion 21/755 98/7206 0.00125263656898 ko04626 Plant-pathogen interaction 7/755 18/7206 0.00152064549808 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/755 14/7206 0.00185871710387 ko04072 Phospholipase D signaling pathway 35/755 197/7206 0.00192409523348 ko04924 Renin secretion 19/755 86/7206 0.00196880454583 ko04964 Proximal tubule bicarbonate reclamation 9/755 29/7206 0.00210060294564 ko04972 Pancreatic secretion 22/755 111/7206 0.00271101826229 ko04744 Phototransduction 10/755 36/7206 0.00302535651716 ko05120 Epithelial cell signaling in Helicobacter pylori infection 19/755 92/7206 0.00315896195197 ko04621 NOD-like receptor signaling pathway 6/755 157/7206 0.00345135621872 ko04612 Antigen processing and presentation 1/755 77/7206 0.00406043208339 ko04740 Olfactory transduction 17/755 80/7206 0.00470487333961 ko00562 Inositol phosphate metabolism 18/755 89/7206 0.0049969158329 ko04960 Aldosterone-regulated sodium reabsorption 10/755 41/7206 0.00825235881284 ko04922 Glucagon signaling pathway 23/755 128/7206 0.00839078580806 ko04540 Gap junction 23/755 128/7206 0.00839078580806 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/755 59/7206 0.00840134294082 ko04350 TGF-beta signaling pathway 3/755 103/7206 0.00847654876451 ko04110 Cell cycle 6/755 145/7206 0.0086927131491 ko04141 Protein processing in endoplasmic reticulum 9/755 184/7206 0.00992804147846 ko04742 Taste transduction 13/755 61/7206 0.0104531583345 ko05169 Epstein-Barr virus infection 11/755 206/7206 0.0109870206562 ko05205 Proteoglycans in cancer 16/755 271/7206 0.0110703142306 ko04071 Sphingolipid signaling pathway 27/755 162/7206 0.0132476026627 ko04550 Signaling pathways regulating pluripotency of stem cells 8/755 165/7206 0.0140003648624 ko04610 Complement and coagulation cascades 2/755 79/7206 0.0150918180277 ko04260 Cardiac muscle contraction 18/755 98/7206 0.0182733329448 ko04630 Jak-STAT signaling pathway 6/755 132/7206 0.0210958846057 ko04015 Rap1 signaling pathway 41/755 278/7206 0.0214249997508 ko05140 Leishmaniasis 2/755 75/7206 0.0214931482042 ko05161 Hepatitis B 9/755 173/7206 0.0226568409534 ko05162 Measles 5/755 120/7206 0.0226616460208 ko04146 Peroxisome 3/755 89/7206 0.0226631424194 ko04750 Inflammatory mediator regulation of TRP channels 21/755 122/7206 0.0236994226133 ko05010 Alzheimer's disease 31/755 202/7206 0.0265408872756 ko00480 Glutathione metabolism 1/755 55/7206 0.0267539875655 ko05321 Inflammatory bowel disease (IBD) 1/755 56/7206 0.0268107662801 ko04214 Apoptosis - fly 2/755 72/7206 0.0309352626671 ko05016 Huntington's disease 13/755 215/7206 0.0310460908987 ko04510 Focal adhesion 15/755 240/7206 0.0312546235143 ko05323 Rheumatoid arthritis 16/755 89/7206 0.033929451185 ko04973 Carbohydrate digestion and absorption 9/755 42/7206 0.0366982099228 ko00590 Arachidonic acid metabolism 1/755 52/7206 0.039109461787 ko04011 MAPK signaling pathway - yeast 1/755 53/7206 0.0395983533881 ko04710 Circadian rhythm 9/755 43/7206 0.0398325521321 ko00240 Pyrimidine metabolism 5/755 110/7206 0.0402119081115 ko00280 Valine, leucine and isoleucine degradation 1/755 54/7206 0.0405236979496 ko05215 Prostate cancer 5/755 111/7206 0.0405649175638 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/755 79/7206 0.0416475084284 ko04064 NF-kappa B signaling pathway 4/755 96/7206 0.0425330109486 ko04915 Estrogen signaling pathway 21/755 131/7206 0.0431335753779 ko05217 Basal cell carcinoma 2/755 68/7206 0.0437495996344 ko04114 Oocyte meiosis 22/755 139/7206 0.0486498625002