ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1155	423/7206	6.18566836518e-56
ko04724	Glutamatergic synapse	87/1155	152/7206	8.63151903224e-32
ko05033	Nicotine addiction	48/1155	56/7206	1.1329294526e-30
ko05032	Morphine addiction	70/1155	110/7206	8.80783866935e-30
ko04727	GABAergic synapse	67/1155	110/7206	6.69798028389e-27
ko04713	Circadian entrainment	74/1155	136/7206	2.85981286181e-25
ko04721	Synaptic vesicle cycle	52/1155	80/7206	4.96073625979e-23
ko04725	Cholinergic synapse	76/1155	160/7206	3.94663941429e-21
ko04728	Dopaminergic synapse	83/1155	185/7206	5.7746107604e-21
ko04024	cAMP signaling pathway	106/1155	279/7206	1.18427944388e-19
ko04723	Retrograde endocannabinoid signaling	78/1155	175/7206	1.50651927735e-19
ko04020	Calcium signaling pathway	100/1155	265/7206	2.33056450919e-18
ko04742	Taste transduction	38/1155	61/7206	3.09221333108e-16
ko04911	Insulin secretion	55/1155	117/7206	2.33176938706e-15
ko04744	Phototransduction	26/1155	36/7206	8.24299513946e-14
ko04261	Adrenergic signaling in cardiomyocytes	76/1155	205/7206	1.02736757388e-13
ko04726	Serotonergic synapse	58/1155	137/7206	1.25696406984e-13
ko04921	Oxytocin signaling pathway	77/1155	209/7206	1.65354540265e-13
ko05031	Amphetamine addiction	40/1155	91/7206	2.12251749512e-10
ko04970	Salivary secretion	41/1155	95/7206	2.52331342486e-10
ko03040	Spliceosome	1/1155	145/7206	3.21004719251e-10
ko04720	Long-term potentiation	41/1155	99/7206	1.15873451784e-09
ko05203	Viral carcinogenesis	14/1155	277/7206	1.41701749832e-08
ko04022	cGMP-PKG signaling pathway	67/1155	216/7206	2.49652482635e-08
ko04925	Aldosterone synthesis and secretion	39/1155	105/7206	1.14718875395e-07
ko04740	Olfactory transduction	32/1155	80/7206	2.05226202873e-07
ko05030	Cocaine addiction	30/1155	73/7206	2.43609676215e-07
ko05168	Herpes simplex infection	7/1155	182/7206	3.13728496798e-07
ko04060	Cytokine-cytokine receptor interaction	8/1155	191/7206	3.68041652801e-07
ko04971	Gastric acid secretion	36/1155	98/7206	4.7884799831e-07
ko05322	Systemic lupus erythematosus	5/1155	151/7206	8.85645601753e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1155	74/7206	1.26216440108e-06
ko04360	Axon guidance	66/1155	233/7206	1.6842062651e-06
ko03013	RNA transport	7/1155	166/7206	2.80583104004e-06
ko05164	Influenza A	7/1155	167/7206	2.90535354883e-06
ko04070	Phosphatidylinositol signaling system	37/1155	112/7206	6.59802206285e-06
ko04966	Collecting duct acid secretion	14/1155	26/7206	9.83470968543e-06
ko04924	Renin secretion	30/1155	86/7206	1.81739330193e-05
ko04972	Pancreatic secretion	36/1155	111/7206	1.86012265484e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1155	79/7206	1.93353649534e-05
ko05414	Dilated cardiomyopathy	36/1155	112/7206	2.09030404793e-05
ko04072	Phospholipase D signaling pathway	54/1155	197/7206	4.36207441912e-05
ko04010	MAPK signaling pathway	79/1155	321/7206	4.70090671909e-05
ko05110	Vibrio cholerae infection	23/1155	63/7206	7.53736089549e-05
ko05205	Proteoglycans in cancer	22/1155	271/7206	0.000132697938224
ko04141	Protein processing in endoplasmic reticulum	12/1155	184/7206	0.000141708238941
ko04514	Cell adhesion molecules (CAMs)	38/1155	130/7206	0.000143375157785
ko04750	Inflammatory mediator regulation of TRP channels	36/1155	122/7206	0.000151993695446
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1155	59/7206	0.000219492224954
ko04260	Cardiac muscle contraction	30/1155	98/7206	0.000253494444547
ko03008	Ribosome biogenesis in eukaryotes	2/1155	79/7206	0.000273591458404
ko04120	Ubiquitin mediated proteolysis	8/1155	138/7206	0.000379334351197
ko05140	Leishmaniasis	2/1155	75/7206	0.000385559858547
ko04923	Regulation of lipolysis in adipocytes	25/1155	77/7206	0.000421896456969
ko04745	Phototransduction - fly	15/1155	38/7206	0.000431420202853
ko05169	Epstein-Barr virus infection	16/1155	206/7206	0.000495673426432
ko04540	Gap junction	36/1155	128/7206	0.000554659041075
ko04976	Bile secretion	25/1155	80/7206	0.000597728399906
ko04915	Estrogen signaling pathway	36/1155	131/7206	0.000698388541285
ko04014	Ras signaling pathway	66/1155	279/7206	0.000812699289472
ko04621	NOD-like receptor signaling pathway	11/1155	157/7206	0.000907071353133
ko04730	Long-term depression	24/1155	78/7206	0.000955426587837
ko05162	Measles	7/1155	120/7206	0.00099538731153
ko05161	Hepatitis B	13/1155	173/7206	0.00108104340011
ko04371	Apelin signaling pathway	45/1155	177/7206	0.00118628370426
ko04110	Cell cycle	10/1155	145/7206	0.00128236355074
ko04612	Antigen processing and presentation	3/1155	77/7206	0.00152864575171
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1155	14/7206	0.00323638411033
ko00240	Pyrimidine metabolism	7/1155	110/7206	0.00361836188028
ko04626	Plant-pathogen interaction	8/1155	18/7206	0.00411821150946
ko00330	Arginine and proline metabolism	2/1155	61/7206	0.00416382558055
ko04610	Complement and coagulation cascades	4/1155	79/7206	0.00495253760345
ko04146	Peroxisome	5/1155	89/7206	0.00515032380228
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1155	100/7206	0.00544494280906
ko05321	Inflammatory bowel disease (IBD)	2/1155	56/7206	0.00578432958151
ko03022	Basal transcription factors	1/1155	44/7206	0.00672458168969
ko05144	Malaria	1/1155	45/7206	0.0068170854145
ko00071	Fatty acid degradation	1/1155	45/7206	0.0068170854145
ko04658	Th1 and Th2 cell differentiation	6/1155	96/7206	0.00710542662976
ko04064	NF-kappa B signaling pathway	6/1155	96/7206	0.00710542662976
ko03420	Nucleotide excision repair	1/1155	46/7206	0.007151124291
ko00562	Inositol phosphate metabolism	24/1155	89/7206	0.0081513797408
ko00480	Glutathione metabolism	2/1155	55/7206	0.00857932128696
ko04510	Focal adhesion	24/1155	240/7206	0.00916727553519
ko04640	Hematopoietic cell lineage	3/1155	64/7206	0.0093970745329
ko00310	Lysine degradation	4/1155	73/7206	0.00974174236301
ko05131	Shigellosis	5/1155	82/7206	0.00974508631034
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1155	182/7206	0.0103954339119
ko04622	RIG-I-like receptor signaling pathway	3/1155	62/7206	0.0135717200783
ko05231	Choline metabolism in cancer	32/1155	134/7206	0.0169089310241
ko04657	IL-17 signaling pathway	6/1155	87/7206	0.0177403799137
ko05133	Pertussis	6/1155	87/7206	0.0177403799137
ko00260	Glycine, serine and threonine metabolism	2/1155	48/7206	0.0178308212929
ko05219	Bladder cancer	2/1155	48/7206	0.0178308212929
ko00380	Tryptophan metabolism	2/1155	50/7206	0.0182485769688
ko04270	Vascular smooth muscle contraction	36/1155	154/7206	0.01901457301
ko00630	Glyoxylate and dicarboxylate metabolism	1/1155	38/7206	0.0234310530716
ko03410	Base excision repair	1/1155	38/7206	0.0234310530716
ko03018	RNA degradation	6/1155	84/7206	0.0239418822558
ko04912	GnRH signaling pathway	29/1155	122/7206	0.024421077764
ko04918	Thyroid hormone synthesis	22/1155	86/7206	0.0250499575354
ko04115	p53 signaling pathway	5/1155	74/7206	0.0253376870911
ko04620	Toll-like receptor signaling pathway	8/1155	100/7206	0.0271914216576
ko04214	Apoptosis - fly	5/1155	72/7206	0.034672654433
ko04330	Notch signaling pathway	4/1155	62/7206	0.0364927456004
ko00280	Valine, leucine and isoleucine degradation	3/1155	54/7206	0.038247098104
ko04071	Sphingolipid signaling pathway	36/1155	162/7206	0.0387521679435
ko04964	Proximal tubule bicarbonate reclamation	9/1155	29/7206	0.0389894426752
ko05166	HTLV-I infection	34/1155	292/7206	0.0413101186175
ko04350	TGF-beta signaling pathway	9/1155	103/7206	0.0420000344164
ko04670	Leukocyte transendothelial migration	15/1155	151/7206	0.0427867982309
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1155	92/7206	0.0447215565972
ko03320	PPAR signaling pathway	5/1155	69/7206	0.0469187361697
ko04114	Oocyte meiosis	31/1155	139/7206	0.046975290039
ko04722	Neurotrophin signaling pathway	35/1155	160/7206	0.0491622825226
ko05215	Prostate cancer	10/1155	111/7206	0.0491639016209
ko04217	Necroptosis	19/1155	178/7206	0.049186167395
ko04210	Apoptosis	19/1155	180/7206	0.0497593802525