ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1105	423/7206	1.80551034221e-50
ko05033	Nicotine addiction	49/1105	56/7206	3.8911530313e-33
ko04724	Glutamatergic synapse	82/1105	152/7206	6.00688439315e-29
ko05032	Morphine addiction	66/1105	110/7206	3.98754492922e-27
ko04727	GABAergic synapse	63/1105	110/7206	2.25003485147e-24
ko04721	Synaptic vesicle cycle	51/1105	80/7206	6.12831989466e-23
ko04713	Circadian entrainment	69/1105	136/7206	1.86258172676e-22
ko04728	Dopaminergic synapse	82/1105	185/7206	1.3916982803e-21
ko04723	Retrograde endocannabinoid signaling	76/1105	175/7206	1.98570448363e-19
ko04725	Cholinergic synapse	70/1105	160/7206	3.43302721086e-18
ko04024	cAMP signaling pathway	100/1105	279/7206	9.29836387538e-18
ko04744	Phototransduction	26/1105	36/7206	2.78533117469e-14
ko04911	Insulin secretion	50/1105	117/7206	7.4124127226e-13
ko04726	Serotonergic synapse	55/1105	137/7206	1.15809371746e-12
ko04921	Oxytocin signaling pathway	73/1105	209/7206	1.31914813487e-12
ko04020	Calcium signaling pathway	86/1105	265/7206	1.61287237553e-12
ko04742	Taste transduction	33/1105	61/7206	2.1232976705e-12
ko04261	Adrenergic signaling in cardiomyocytes	70/1105	205/7206	1.04284953901e-11
ko05031	Amphetamine addiction	38/1105	91/7206	9.83017965157e-10
ko03040	Spliceosome	1/1105	145/7206	1.36792289582e-09
ko04720	Long-term potentiation	39/1105	99/7206	4.44231604938e-09
ko05203	Viral carcinogenesis	13/1105	277/7206	2.05372797237e-08
ko04970	Salivary secretion	36/1105	95/7206	5.74449546556e-08
ko05030	Cocaine addiction	30/1105	73/7206	8.89677655663e-08
ko05168	Herpes simplex infection	6/1105	182/7206	1.88799819274e-07
ko04925	Aldosterone synthesis and secretion	37/1105	105/7206	3.53196370555e-07
ko04060	Cytokine-cytokine receptor interaction	7/1105	191/7206	3.57037379422e-07
ko04360	Axon guidance	64/1105	233/7206	1.72328210128e-06
ko05322	Systemic lupus erythematosus	5/1105	151/7206	3.0868925253e-06
ko04740	Olfactory transduction	29/1105	80/7206	4.73016595615e-06
ko04022	cGMP-PKG signaling pathway	59/1105	216/7206	4.83863373969e-06
ko05164	Influenza A	7/1105	167/7206	6.16122378515e-06
ko03013	RNA transport	7/1105	166/7206	9.10860128278e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1105	79/7206	9.61150862627e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1105	74/7206	1.02337368484e-05
ko04971	Gastric acid secretion	32/1105	98/7206	1.43136297451e-05
ko04070	Phosphatidylinositol signaling system	35/1105	112/7206	1.68578427901e-05
ko04010	MAPK signaling pathway	77/1105	321/7206	3.3192311588e-05
ko04966	Collecting duct acid secretion	13/1105	26/7206	3.55710951873e-05
ko04141	Protein processing in endoplasmic reticulum	10/1105	184/7206	4.25044334458e-05
ko05205	Proteoglycans in cancer	20/1105	271/7206	9.66682598754e-05
ko04260	Cardiac muscle contraction	30/1105	98/7206	0.000106598391118
ko05414	Dilated cardiomyopathy	33/1105	112/7206	0.00015822950033
ko04072	Phospholipase D signaling pathway	50/1105	197/7206	0.0001872047202
ko05169	Epstein-Barr virus infection	14/1105	206/7206	0.000250867565208
ko04745	Phototransduction - fly	15/1105	38/7206	0.000262737920389
ko04972	Pancreatic secretion	32/1105	111/7206	0.000263745058328
ko04621	NOD-like receptor signaling pathway	9/1105	157/7206	0.000291095240056
ko04514	Cell adhesion molecules (CAMs)	36/1105	130/7206	0.00029560255249
ko05161	Hepatitis B	11/1105	173/7206	0.000382855855709
ko04110	Cell cycle	8/1105	145/7206	0.00040434872344
ko03008	Ribosome biogenesis in eukaryotes	2/1105	79/7206	0.000411346700637
ko04924	Renin secretion	26/1105	86/7206	0.00041254301086
ko05140	Leishmaniasis	2/1105	75/7206	0.000598231113689
ko04730	Long-term depression	24/1105	78/7206	0.000667939548358
ko04064	NF-kappa B signaling pathway	4/1105	96/7206	0.000884066970882
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1105	100/7206	0.0010946738553
ko05110	Vibrio cholerae infection	20/1105	63/7206	0.00113245753312
ko04014	Ras signaling pathway	63/1105	279/7206	0.00120192988354
ko04540	Gap junction	33/1105	128/7206	0.00182616962804
ko00240	Pyrimidine metabolism	6/1105	110/7206	0.0019720308069
ko05162	Measles	7/1105	120/7206	0.00197941753452
ko04612	Antigen processing and presentation	3/1105	77/7206	0.00229208088096
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1105	14/7206	0.0024898309366
ko04120	Ubiquitin mediated proteolysis	9/1105	138/7206	0.00259479968299
ko04146	Peroxisome	4/1105	89/7206	0.00262767570104
ko04640	Hematopoietic cell lineage	2/1105	64/7206	0.00279806289665
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1105	59/7206	0.00298704317671
ko04915	Estrogen signaling pathway	33/1105	131/7206	0.00303784062781
ko04976	Bile secretion	22/1105	80/7206	0.00452745301738
ko05166	HTLV-I infection	28/1105	292/7206	0.00465893456438
ko00310	Lysine degradation	3/1105	73/7206	0.00480914730406
ko04350	TGF-beta signaling pathway	6/1105	103/7206	0.00531941871328
ko04140	Autophagy - animal	13/1105	164/7206	0.00589566402991
ko04923	Regulation of lipolysis in adipocytes	21/1105	77/7206	0.00626902978291
ko04210	Apoptosis	15/1105	180/7206	0.00629065811983
ko03420	Nucleotide excision repair	1/1105	46/7206	0.00693817041068
ko05219	Bladder cancer	1/1105	48/7206	0.00735477155042
ko05321	Inflammatory bowel disease (IBD)	2/1105	56/7206	0.00867672247305
ko04658	Th1 and Th2 cell differentiation	6/1105	96/7206	0.00977716014638
ko03022	Basal transcription factors	1/1105	44/7206	0.0104233602495
ko04510	Focal adhesion	23/1105	240/7206	0.0105195206564
ko05144	Malaria	1/1105	45/7206	0.0107864582119
ko00071	Fatty acid degradation	1/1105	45/7206	0.0107864582119
ko00480	Glutathione metabolism	2/1105	55/7206	0.0129412523191
ko04626	Plant-pathogen interaction	7/1105	18/7206	0.0131949586828
ko03018	RNA degradation	5/1105	84/7206	0.0139126269541
ko04115	p53 signaling pathway	4/1105	74/7206	0.0140669646894
ko04371	Apelin signaling pathway	39/1105	177/7206	0.0150584748617
ko04217	Necroptosis	16/1105	178/7206	0.015179410641
ko05145	Toxoplasmosis	10/1105	126/7206	0.017429491361
ko00590	Arachidonic acid metabolism	2/1105	52/7206	0.018562700753
ko00330	Arginine and proline metabolism	3/1105	61/7206	0.0193901812246
ko04137	Mitophagy - animal	5/1105	82/7206	0.0194084119971
ko04218	Cellular senescence	16/1105	177/7206	0.019516254586
ko04622	RIG-I-like receptor signaling pathway	3/1105	62/7206	0.0197174982464
ko04214	Apoptosis - fly	4/1105	72/7206	0.0198736070851
ko04630	Jak-STAT signaling pathway	11/1105	132/7206	0.0205606031542
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1105	182/7206	0.0215676280447
ko04750	Inflammatory mediator regulation of TRP channels	28/1105	122/7206	0.0224614562849
ko05202	Transcriptional misregulation in cancer	18/1105	188/7206	0.0239672923244
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1105	40/7206	0.0243487053962
ko04657	IL-17 signaling pathway	6/1105	87/7206	0.0244024677223
ko05133	Pertussis	6/1105	87/7206	0.0244024677223
ko00260	Glycine, serine and threonine metabolism	2/1105	48/7206	0.0262756991393
ko03320	PPAR signaling pathway	4/1105	69/7206	0.0274029548181
ko04668	TNF signaling pathway	10/1105	120/7206	0.0295858669057
ko05215	Prostate cancer	9/1105	111/7206	0.0329361059196
ko04964	Proximal tubule bicarbonate reclamation	9/1105	29/7206	0.0331607475763
ko05206	MicroRNAs in cancer	17/1105	177/7206	0.0339942566351
ko00982	Drug metabolism - cytochrome P450	1/1105	37/7206	0.035553987519
ko04930	Type II diabetes mellitus	14/1105	54/7206	0.0368423277239
ko00562	Inositol phosphate metabolism	21/1105	89/7206	0.0372533269716
ko04670	Leukocyte transendothelial migration	14/1105	151/7206	0.0391347874321
ko05131	Shigellosis	6/1105	82/7206	0.0440559209756
ko04620	Toll-like receptor signaling pathway	8/1105	100/7206	0.0487455486184
ko04918	Thyroid hormone synthesis	20/1105	86/7206	0.0492022651013