ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 67/251 423/7206 1.4414418936e-27 ko04724 Glutamatergic synapse 34/251 152/7206 7.62555037386e-19 ko05033 Nicotine addiction 20/251 56/7206 8.3562436714e-16 ko04727 GABAergic synapse 23/251 110/7206 2.10350163554e-12 ko04713 Circadian entrainment 25/251 136/7206 4.66632178868e-12 ko04723 Retrograde endocannabinoid signaling 28/251 175/7206 7.77176987588e-12 ko04728 Dopaminergic synapse 28/251 185/7206 3.08096419756e-11 ko05014 Amyotrophic lateral sclerosis (ALS) 17/251 74/7206 3.70181943439e-10 ko05032 Morphine addiction 19/251 110/7206 5.70003582377e-09 ko04721 Synaptic vesicle cycle 16/251 80/7206 1.0685104048e-08 ko04725 Cholinergic synapse 21/251 160/7206 1.32350602776e-07 ko04726 Serotonergic synapse 19/251 137/7206 2.23184565257e-07 ko04730 Long-term depression 14/251 78/7206 3.76193988568e-07 ko04720 Long-term potentiation 15/251 99/7206 1.39379722618e-06 ko04261 Adrenergic signaling in cardiomyocytes 22/251 205/7206 2.24467343783e-06 ko05031 Amphetamine addiction 14/251 91/7206 2.61775374473e-06 ko04921 Oxytocin signaling pathway 22/251 209/7206 3.10108873375e-06 ko04024 cAMP signaling pathway 24/251 279/7206 3.52588035662e-05 ko05030 Cocaine addiction 10/251 73/7206 0.000197398715555 ko04020 Calcium signaling pathway 21/251 265/7206 0.000415386909207 ko04970 Salivary secretion 11/251 95/7206 0.000430715844609 ko04260 Cardiac muscle contraction 11/251 98/7206 0.000563721294477 ko04911 Insulin secretion 12/251 117/7206 0.000729197358036 ko04010 MAPK signaling pathway 23/251 321/7206 0.000876878135153 ko04022 cGMP-PKG signaling pathway 17/251 216/7206 0.00178497443512 ko04742 Taste transduction 7/251 61/7206 0.00501274327983 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 8/251 79/7206 0.00597220280142 ko04924 Renin secretion 8/251 86/7206 0.00986910214458 ko05034 Alcoholism 16/251 238/7206 0.0105892257368 ko04966 Collecting duct acid secretion 4/251 26/7206 0.0117444241407 ko04962 Vasopressin-regulated water reabsorption 6/251 58/7206 0.0149717335204 ko04514 Cell adhesion molecules (CAMs) 10/251 130/7206 0.0150249634966 ko04972 Pancreatic secretion 9/251 111/7206 0.0150284372545 ko04961 Endocrine and other factor-regulated calcium reabsorption 6/251 59/7206 0.0161960250899 ko05168 Herpes simplex infection 1/251 182/7206 0.0220589143077 ko05410 Hypertrophic cardiomyopathy (HCM) 8/251 100/7206 0.0228991115356 ko04145 Phagosome 11/251 162/7206 0.0286499227934 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/251 1/7206 0.0348320843742 ko04745 Phototransduction - fly 4/251 38/7206 0.0419825341907 ko04014 Ras signaling pathway 16/251 279/7206 0.0444301175631 ko04915 Estrogen signaling pathway 9/251 131/7206 0.048047805718