ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1137	423/7206	1.90934760369e-48
ko04724	Glutamatergic synapse	85/1137	152/7206	1.40414402708e-30
ko05033	Nicotine addiction	47/1137	56/7206	1.5995894395e-29
ko04721	Synaptic vesicle cycle	54/1137	80/7206	1.9637341241e-25
ko04727	GABAergic synapse	61/1137	110/7206	5.9129935241e-22
ko05032	Morphine addiction	61/1137	110/7206	5.9129935241e-22
ko04713	Circadian entrainment	68/1137	136/7206	5.75754038582e-21
ko04728	Dopaminergic synapse	82/1137	185/7206	9.24333211634e-21
ko04725	Cholinergic synapse	73/1137	160/7206	1.77233685168e-19
ko04024	cAMP signaling pathway	99/1137	279/7206	1.5642078818e-16
ko04723	Retrograde endocannabinoid signaling	72/1137	175/7206	3.32631823942e-16
ko04742	Taste transduction	37/1137	61/7206	1.58074837642e-15
ko04020	Calcium signaling pathway	92/1137	265/7206	1.06483292073e-14
ko04911	Insulin secretion	53/1137	117/7206	2.65619631758e-14
ko04726	Serotonergic synapse	57/1137	137/7206	2.52324029503e-13
ko04261	Adrenergic signaling in cardiomyocytes	72/1137	205/7206	4.49760913479e-12
ko04921	Oxytocin signaling pathway	73/1137	209/7206	5.80090600068e-12
ko05031	Amphetamine addiction	41/1137	91/7206	2.90381846066e-11
ko04720	Long-term potentiation	43/1137	99/7206	4.20938168564e-11
ko04360	Axon guidance	75/1137	233/7206	2.09670874964e-10
ko03040	Spliceosome	1/1137	145/7206	5.16597985884e-10
ko04740	Olfactory transduction	35/1137	80/7206	2.1902810771e-09
ko04970	Salivary secretion	39/1137	95/7206	2.51468738971e-09
ko04744	Phototransduction	21/1137	36/7206	6.21774139622e-09
ko05168	Herpes simplex infection	5/1137	182/7206	1.30383725363e-08
ko05203	Viral carcinogenesis	14/1137	277/7206	2.94388919807e-08
ko03013	RNA transport	5/1137	166/7206	1.35207741528e-07
ko05030	Cocaine addiction	30/1137	73/7206	1.70738835902e-07
ko04925	Aldosterone synthesis and secretion	38/1137	105/7206	2.33730660315e-07
ko04260	Cardiac muscle contraction	36/1137	98/7206	3.43457248146e-07
ko04060	Cytokine-cytokine receptor interaction	8/1137	191/7206	5.45577771409e-07
ko05164	Influenza A	6/1137	167/7206	8.08668708926e-07
ko04971	Gastric acid secretion	35/1137	98/7206	9.96246315428e-07
ko04966	Collecting duct acid secretion	15/1137	26/7206	1.1799893731e-06
ko04022	cGMP-PKG signaling pathway	61/1137	216/7206	2.46117384192e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1137	74/7206	3.1615228552e-06
ko04924	Renin secretion	31/1137	86/7206	3.51328159752e-06
ko04120	Ubiquitin mediated proteolysis	5/1137	138/7206	8.77102919647e-06
ko04540	Gap junction	40/1137	128/7206	1.17105769591e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1137	59/7206	1.34146897095e-05
ko04010	MAPK signaling pathway	80/1137	321/7206	1.43222664591e-05
ko04514	Cell adhesion molecules (CAMs)	40/1137	130/7206	1.47742663356e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1137	79/7206	1.47931881454e-05
ko04141	Protein processing in endoplasmic reticulum	10/1137	184/7206	2.09971749795e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1137	79/7206	3.25444518267e-05
ko05169	Epstein-Barr virus infection	13/1137	206/7206	4.05773933755e-05
ko04621	NOD-like receptor signaling pathway	8/1137	157/7206	5.29387378955e-05
ko04745	Phototransduction - fly	16/1137	38/7206	9.34493525063e-05
ko05322	Systemic lupus erythematosus	8/1137	151/7206	0.000102872724192
ko05162	Measles	5/1137	120/7206	0.00011537432418
ko05110	Vibrio cholerae infection	22/1137	63/7206	0.00016352480058
ko05414	Dilated cardiomyopathy	33/1137	112/7206	0.000209574410961
ko04610	Complement and coagulation cascades	2/1137	79/7206	0.000265875040834
ko04730	Long-term depression	25/1137	78/7206	0.000423507592573
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1137	14/7206	0.000461189601955
ko04064	NF-kappa B signaling pathway	4/1137	96/7206	0.000599675359149
ko05140	Leishmaniasis	2/1137	75/7206	0.000610857586426
ko04972	Pancreatic secretion	31/1137	111/7206	0.000930433680863
ko00480	Glutathione metabolism	1/1137	55/7206	0.00133992364947
ko00240	Pyrimidine metabolism	6/1137	110/7206	0.00138513509838
ko05161	Hepatitis B	13/1137	173/7206	0.00145793319508
ko04750	Inflammatory mediator regulation of TRP channels	33/1137	122/7206	0.00151156151294
ko04976	Bile secretion	24/1137	80/7206	0.00165033563273
ko04110	Cell cycle	10/1137	145/7206	0.00175647787551
ko04146	Peroxisome	4/1137	89/7206	0.00179180651953
ko05205	Proteoglycans in cancer	25/1137	271/7206	0.00211377489399
ko04915	Estrogen signaling pathway	34/1137	131/7206	0.00232705107742
ko04014	Ras signaling pathway	63/1137	279/7206	0.00245356631118
ko04640	Hematopoietic cell lineage	2/1137	64/7206	0.00280047327603
ko04964	Proximal tubule bicarbonate reclamation	11/1137	29/7206	0.00318285499045
ko04214	Apoptosis - fly	3/1137	72/7206	0.00322550499439
ko00310	Lysine degradation	3/1137	73/7206	0.00323183849978
ko00590	Arachidonic acid metabolism	1/1137	52/7206	0.00324029921998
ko03018	RNA degradation	4/1137	84/7206	0.00365869871375
ko04626	Plant-pathogen interaction	8/1137	18/7206	0.00372342184636
ko01200	Carbon metabolism	9/1137	128/7206	0.00455098562179
ko04072	Phospholipase D signaling pathway	46/1137	197/7206	0.00524884289009
ko00071	Fatty acid degradation	1/1137	45/7206	0.00680510854519
ko03420	Nucleotide excision repair	1/1137	46/7206	0.00696868479933
ko04612	Antigen processing and presentation	4/1137	77/7206	0.00701588436216
ko05418	Fluid shear stress and atherosclerosis	15/1137	173/7206	0.00799606318932
ko05321	Inflammatory bowel disease (IBD)	2/1137	56/7206	0.00871292652886
ko04916	Melanogenesis	34/1137	142/7206	0.0101491279269
ko00983	Drug metabolism - other enzymes	1/1137	42/7206	0.0101752904553
ko01524	Platinum drug resistance	4/1137	76/7206	0.0102441488502
ko03022	Basal transcription factors	1/1137	44/7206	0.0107364915802
ko04668	TNF signaling pathway	9/1137	120/7206	0.0109088857913
ko04070	Phosphatidylinositol signaling system	28/1137	112/7206	0.0122303682264
ko04620	Toll-like receptor signaling pathway	7/1137	100/7206	0.0124103713926
ko00280	Valine, leucine and isoleucine degradation	2/1137	54/7206	0.0130157453587
ko05145	Toxoplasmosis	10/1137	126/7206	0.0131295473573
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1137	182/7206	0.0133277293952
ko04622	RIG-I-like receptor signaling pathway	3/1137	62/7206	0.0134658762423
ko00600	Sphingolipid metabolism	3/1137	63/7206	0.0137133794689
ko05131	Shigellosis	5/1137	82/7206	0.0137676464013
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1137	26/7206	0.0144602905153
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1137	40/7206	0.0152383372201
ko04140	Autophagy - animal	15/1137	164/7206	0.0167775117585
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1137	100/7206	0.0177561648673
ko05133	Pertussis	6/1137	87/7206	0.0178003392874
ko00380	Tryptophan metabolism	2/1137	50/7206	0.0180371800967
ko03320	PPAR signaling pathway	4/1137	69/7206	0.0192294233128
ko00330	Arginine and proline metabolism	3/1137	61/7206	0.0199000847172
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1137	92/7206	0.020421701018
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1137	15/7206	0.0211765079658
ko00982	Drug metabolism - cytochrome P450	1/1137	37/7206	0.0226317476075
ko04930	Type II diabetes mellitus	15/1137	54/7206	0.0228504459567
ko00630	Glyoxylate and dicarboxylate metabolism	1/1137	38/7206	0.0230517957613
ko00270	Cysteine and methionine metabolism	2/1137	47/7206	0.0259488235132
ko04371	Apelin signaling pathway	39/1137	177/7206	0.0276843105813
ko04210	Apoptosis	18/1137	180/7206	0.0295355989194
ko04630	Jak-STAT signaling pathway	12/1137	132/7206	0.030190518849
ko05166	HTLV-I infection	33/1137	292/7206	0.0328252725755
ko04912	GnRH signaling pathway	28/1137	122/7206	0.0330737747895
ko00860	Porphyrin and chlorophyll metabolism	1/1137	34/7206	0.0336667921212
ko04115	p53 signaling pathway	5/1137	74/7206	0.0354130857608
ko05146	Amoebiasis	8/1137	99/7206	0.0361906929648
ko04218	Cellular senescence	18/1137	177/7206	0.0367447452071
ko00561	Glycerolipid metabolism	4/1137	63/7206	0.036757913436
ko05144	Malaria	2/1137	45/7206	0.0377771271239
ko00620	Pyruvate metabolism	2/1137	46/7206	0.0390732815898
ko05222	Small cell lung cancer	7/1137	89/7206	0.039694407848
ko04923	Regulation of lipolysis in adipocytes	19/1137	77/7206	0.0398468097158
ko04138	Autophagy - yeast	6/1137	81/7206	0.0444183283584
ko04962	Vasopressin-regulated water reabsorption	15/1137	58/7206	0.0448462300507
ko05034	Alcoholism	49/1137	238/7206	0.0461282568825