ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	207/1335	423/7206	4.16087640436e-49
ko04724	Glutamatergic synapse	92/1335	152/7206	4.32112105653e-31
ko05033	Nicotine addiction	47/1335	56/7206	2.61409119614e-26
ko05032	Morphine addiction	68/1335	110/7206	5.46659221752e-24
ko04713	Circadian entrainment	77/1335	136/7206	1.46353860427e-23
ko04727	GABAergic synapse	67/1335	110/7206	3.99804001996e-23
ko04728	Dopaminergic synapse	86/1335	185/7206	1.15227863719e-18
ko04020	Calcium signaling pathway	109/1335	265/7206	2.96166340744e-18
ko04725	Cholinergic synapse	76/1335	160/7206	2.7520461012e-17
ko04723	Retrograde endocannabinoid signaling	80/1335	175/7206	6.6421430971e-17
ko04721	Synaptic vesicle cycle	48/1335	80/7206	1.57352608404e-16
ko04024	cAMP signaling pathway	107/1335	279/7206	2.2346502364e-15
ko04726	Serotonergic synapse	65/1335	137/7206	6.32254515808e-15
ko04742	Taste transduction	38/1335	61/7206	4.21712558472e-14
ko04744	Phototransduction	26/1335	36/7206	2.77410918689e-12
ko04911	Insulin secretion	54/1335	117/7206	5.15238928324e-12
ko04921	Oxytocin signaling pathway	80/1335	209/7206	1.12542762118e-11
ko05031	Amphetamine addiction	44/1335	91/7206	7.30135035138e-11
ko03010	Ribosome	1/1335	129/7206	1.22120677579e-10
ko04720	Long-term potentiation	45/1335	99/7206	5.82042484924e-10
ko03040	Spliceosome	4/1335	145/7206	8.14659413949e-09
ko04970	Salivary secretion	42/1335	95/7206	9.19232097405e-09
ko05322	Systemic lupus erythematosus	5/1335	151/7206	2.88911009488e-08
ko04925	Aldosterone synthesis and secretion	43/1335	105/7206	7.3656538643e-08
ko03013	RNA transport	8/1335	166/7206	2.60411539318e-07
ko05030	Cocaine addiction	32/1335	73/7206	7.95128867735e-07
ko04261	Adrenergic signaling in cardiomyocytes	67/1335	205/7206	9.26885749671e-07
ko04966	Collecting duct acid secretion	16/1335	26/7206	1.43656773088e-06
ko05203	Viral carcinogenesis	23/1335	277/7206	1.77042676557e-06
ko04110	Cell cycle	7/1335	145/7206	2.15439648768e-06
ko04971	Gastric acid secretion	38/1335	98/7206	2.34313665702e-06
ko04022	cGMP-PKG signaling pathway	68/1335	216/7206	2.9999731091e-06
ko05168	Herpes simplex infection	12/1335	182/7206	4.35231936352e-06
ko04070	Phosphatidylinositol signaling system	40/1335	112/7206	1.2877677876e-05
ko04740	Olfactory transduction	31/1335	80/7206	1.813717743e-05
ko04072	Phospholipase D signaling pathway	61/1335	197/7206	2.29845969168e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1335	79/7206	2.79391974985e-05
ko04972	Pancreatic secretion	39/1335	111/7206	3.33530319757e-05
ko04730	Long-term depression	30/1335	78/7206	4.57153317348e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1335	74/7206	0.00010877132837
ko04270	Vascular smooth muscle contraction	48/1335	154/7206	0.000134689754674
ko04014	Ras signaling pathway	77/1335	279/7206	0.000148991131921
ko04745	Phototransduction - fly	17/1335	38/7206	0.000179018515921
ko04141	Protein processing in endoplasmic reticulum	16/1335	184/7206	0.000233854263908
ko05169	Epstein-Barr virus infection	19/1335	206/7206	0.000247358476022
ko00520	Amino sugar and nucleotide sugar metabolism	1/1335	55/7206	0.000326979639467
ko04976	Bile secretion	28/1335	80/7206	0.000412018464114
ko04540	Gap junction	40/1335	128/7206	0.000491209700557
ko04010	MAPK signaling pathway	84/1335	321/7206	0.000527910715369
ko04360	Axon guidance	64/1335	233/7206	0.000768147528976
ko04120	Ubiquitin mediated proteolysis	11/1335	138/7206	0.000794619247489
ko05164	Influenza A	15/1335	167/7206	0.000803600665076
ko04750	Inflammatory mediator regulation of TRP channels	38/1335	122/7206	0.000864988485494
ko04915	Estrogen signaling pathway	40/1335	131/7206	0.000874633355326
ko05161	Hepatitis B	16/1335	173/7206	0.000986764551388
ko04964	Proximal tubule bicarbonate reclamation	13/1335	29/7206	0.00100730920984
ko04710	Circadian rhythm	17/1335	43/7206	0.00117448872428
ko04514	Cell adhesion molecules (CAMs)	39/1335	130/7206	0.0013085692062
ko04630	Jak-STAT signaling pathway	11/1335	132/7206	0.00141829675048
ko04371	Apelin signaling pathway	50/1335	177/7206	0.0015884172622
ko05144	Malaria	1/1335	45/7206	0.00171117468032
ko05110	Vibrio cholerae infection	22/1335	63/7206	0.00171754735492
ko03420	Nucleotide excision repair	1/1335	46/7206	0.00175371309661
ko04924	Renin secretion	28/1335	86/7206	0.00181849044929
ko04621	NOD-like receptor signaling pathway	15/1335	157/7206	0.00244497593785
ko04060	Cytokine-cytokine receptor interaction	20/1335	191/7206	0.00247631641749
ko05166	HTLV-I infection	35/1335	292/7206	0.00263628678955
ko03022	Basal transcription factors	1/1335	44/7206	0.00269961486809
ko05205	Proteoglycans in cancer	32/1335	271/7206	0.00308504390204
ko04623	Cytosolic DNA-sensing pathway	1/1335	41/7206	0.00396438933306
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1335	79/7206	0.00505536894586
ko03410	Base excision repair	1/1335	38/7206	0.00598695382739
ko05162	Measles	11/1335	120/7206	0.00611633389802
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1335	182/7206	0.00663845702676
ko04064	NF-kappa B signaling pathway	8/1335	96/7206	0.00771062134724
ko04922	Glucagon signaling pathway	36/1335	128/7206	0.0078318710864
ko04930	Type II diabetes mellitus	18/1335	54/7206	0.0079388440598
ko05133	Pertussis	7/1335	87/7206	0.00816037628604
ko04610	Complement and coagulation cascades	6/1335	79/7206	0.00853299166164
ko04912	GnRH signaling pathway	34/1335	122/7206	0.0096440975456
ko04626	Plant-pathogen interaction	8/1335	18/7206	0.0101943616936
ko05206	MicroRNAs in cancer	20/1335	177/7206	0.0106682047844
ko05130	Pathogenic Escherichia coli infection	6/1335	77/7206	0.0117311118602
ko04113	Meiosis - yeast	5/1335	70/7206	0.0123766295057
ko05016	Huntington's disease	26/1335	215/7206	0.012407643077
ko04330	Notch signaling pathway	4/1335	62/7206	0.0126048726638
ko04622	RIG-I-like receptor signaling pathway	4/1335	62/7206	0.0126048726638
ko00562	Inositol phosphate metabolism	26/1335	89/7206	0.0129189086211
ko00860	Porphyrin and chlorophyll metabolism	1/1335	34/7206	0.0136544434204
ko00910	Nitrogen metabolism	8/1335	19/7206	0.0148007948889
ko04960	Aldosterone-regulated sodium reabsorption	14/1335	41/7206	0.0148180887086
ko05140	Leishmaniasis	6/1335	75/7206	0.0161089452204
ko04658	Th1 and Th2 cell differentiation	9/1335	96/7206	0.0170995224367
ko05231	Choline metabolism in cancer	36/1335	134/7206	0.0177638080397
ko00240	Pyrimidine metabolism	11/1335	110/7206	0.0184108498866
ko04217	Necroptosis	21/1335	178/7206	0.0187090645184
ko05414	Dilated cardiomyopathy	31/1335	112/7206	0.019005665769
ko05131	Shigellosis	7/1335	82/7206	0.0209586318125
ko00965	Betalain biosynthesis	3/1335	4/7206	0.0218667209765
ko05202	Transcriptional misregulation in cancer	23/1335	188/7206	0.0224125217043
ko05321	Inflammatory bowel disease (IBD)	4/1335	56/7206	0.0242948891779
ko05219	Bladder cancer	3/1335	48/7206	0.0245744958171
ko04210	Apoptosis	22/1335	180/7206	0.0254453173568
ko04260	Cardiac muscle contraction	27/1335	98/7206	0.0256209137198
ko04923	Regulation of lipolysis in adipocytes	22/1335	77/7206	0.0269872133352
ko05145	Toxoplasmosis	14/1335	126/7206	0.0280238441469
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1335	14/7206	0.0309885217127
ko05340	Primary immunodeficiency	1/1335	30/7206	0.0312785844525
ko03018	RNA degradation	8/1335	84/7206	0.0332360372786
ko00280	Valine, leucine and isoleucine degradation	4/1335	54/7206	0.0339030649635
ko04672	Intestinal immune network for IgA production	2/1335	37/7206	0.0344267252997
ko05416	Viral myocarditis	4/1335	55/7206	0.0345529858102
ko04612	Antigen processing and presentation	7/1335	77/7206	0.0374011217555
ko04146	Peroxisome	9/1335	89/7206	0.039160225593
ko05222	Small cell lung cancer	9/1335	89/7206	0.039160225593
ko05217	Basal cell carcinoma	6/1335	68/7206	0.0403569318841
ko05200	Pathways in cancer	74/1335	492/7206	0.0408318275534
ko04962	Vasopressin-regulated water reabsorption	17/1335	58/7206	0.0410878785765
ko04973	Carbohydrate digestion and absorption	13/1335	42/7206	0.0457594362537
ko04115	p53 signaling pathway	7/1335	74/7206	0.0491477668711