ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	206/1226	423/7206	5.59144191007e-55
ko04724	Glutamatergic synapse	91/1226	152/7206	3.00203077014e-33
ko05033	Nicotine addiction	50/1226	56/7206	1.68851677712e-32
ko05032	Morphine addiction	70/1226	110/7206	4.08609220884e-28
ko04727	GABAergic synapse	68/1226	110/7206	3.04844983929e-26
ko04713	Circadian entrainment	77/1226	136/7206	4.94347850741e-26
ko04721	Synaptic vesicle cycle	56/1226	80/7206	7.00362648484e-26
ko04728	Dopaminergic synapse	87/1226	185/7206	7.82923513762e-22
ko04725	Cholinergic synapse	77/1226	160/7206	3.38658722643e-20
ko04024	cAMP signaling pathway	108/1226	279/7206	1.27017334303e-18
ko04723	Retrograde endocannabinoid signaling	79/1226	175/7206	1.41884952012e-18
ko04742	Taste transduction	39/1226	61/7206	2.77222353908e-16
ko04020	Calcium signaling pathway	99/1226	265/7206	5.50231219294e-16
ko04911	Insulin secretion	57/1226	117/7206	1.4890452868e-15
ko04744	Phototransduction	27/1226	36/7206	2.60139659193e-14
ko04726	Serotonergic synapse	61/1226	137/7206	2.87882770402e-14
ko04921	Oxytocin signaling pathway	81/1226	209/7206	3.10709521948e-14
ko04720	Long-term potentiation	48/1226	99/7206	3.37657086741e-13
ko04740	Olfactory transduction	41/1226	80/7206	1.80301261697e-12
ko05031	Amphetamine addiction	44/1226	91/7206	3.73334635508e-12
ko04261	Adrenergic signaling in cardiomyocytes	75/1226	205/7206	9.08436026818e-12
ko04970	Salivary secretion	44/1226	95/7206	2.35094820928e-11
ko03040	Spliceosome	1/1226	145/7206	7.10708477328e-11
ko05203	Viral carcinogenesis	16/1226	277/7206	1.9197141943e-08
ko04971	Gastric acid secretion	40/1226	98/7206	2.80990807068e-08
ko04966	Collecting duct acid secretion	17/1226	26/7206	5.05242973402e-08
ko04925	Aldosterone synthesis and secretion	41/1226	105/7206	5.64125191595e-08
ko05168	Herpes simplex infection	7/1226	182/7206	6.18315107789e-08
ko04360	Axon guidance	73/1226	233/7206	6.296210808e-08
ko05030	Cocaine addiction	32/1226	73/7206	6.52883712483e-08
ko04060	Cytokine-cytokine receptor interaction	8/1226	191/7206	7.50512695773e-08
ko04022	cGMP-PKG signaling pathway	67/1226	216/7206	2.77830475778e-07
ko03013	RNA transport	7/1226	166/7206	5.68866984546e-07
ko04540	Gap junction	45/1226	128/7206	5.71651269572e-07
ko04120	Ubiquitin mediated proteolysis	5/1226	138/7206	1.68229652924e-06
ko04924	Renin secretion	33/1226	86/7206	1.79538821424e-06
ko05110	Vibrio cholerae infection	26/1226	63/7206	4.44103495391e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1226	74/7206	5.32750899367e-06
ko04260	Cardiac muscle contraction	35/1226	98/7206	7.97384532846e-06
ko05164	Influenza A	9/1226	167/7206	8.95177161083e-06
ko04141	Protein processing in endoplasmic reticulum	11/1226	184/7206	9.79552571994e-06
ko04010	MAPK signaling pathway	85/1226	321/7206	1.28284131263e-05
ko04745	Phototransduction - fly	18/1226	38/7206	1.36776345893e-05
ko04514	Cell adhesion molecules (CAMs)	42/1226	130/7206	1.59752093684e-05
ko04730	Long-term depression	29/1226	78/7206	2.23027695517e-05
ko05322	Systemic lupus erythematosus	8/1226	151/7206	2.38801573904e-05
ko04972	Pancreatic secretion	37/1226	111/7206	3.06705785264e-05
ko04626	Plant-pathogen interaction	11/1226	18/7206	3.28126142496e-05
ko04110	Cell cycle	8/1226	145/7206	4.67646702548e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1226	59/7206	6.27382028445e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1226	79/7206	6.27918275781e-05
ko05169	Epstein-Barr virus infection	15/1226	206/7206	6.51452991148e-05
ko05205	Proteoglycans in cancer	23/1226	271/7206	6.69293210147e-05
ko04621	NOD-like receptor signaling pathway	10/1226	157/7206	9.69940182838e-05
ko04610	Complement and coagulation cascades	2/1226	79/7206	0.000111367282952
ko03008	Ribosome biogenesis in eukaryotes	2/1226	79/7206	0.000111367282952
ko05162	Measles	6/1226	120/7206	0.000115042149401
ko04976	Bile secretion	28/1226	80/7206	0.000119556720943
ko05140	Leishmaniasis	2/1226	75/7206	0.000161632632423
ko04064	NF-kappa B signaling pathway	4/1226	96/7206	0.000182090834514
ko05414	Dilated cardiomyopathy	35/1226	112/7206	0.000187954148432
ko04070	Phosphatidylinositol signaling system	35/1226	112/7206	0.000187954148432
ko04072	Phospholipase D signaling pathway	53/1226	197/7206	0.000480737721973
ko04146	Peroxisome	4/1226	89/7206	0.000549698645762
ko04750	Inflammatory mediator regulation of TRP channels	36/1226	122/7206	0.000568925009166
ko04915	Estrogen signaling pathway	38/1226	131/7206	0.00057746873002
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1226	14/7206	0.000782404367004
ko04014	Ras signaling pathway	69/1226	279/7206	0.000819998486024
ko00480	Glutathione metabolism	1/1226	55/7206	0.000848171143086
ko05161	Hepatitis B	14/1226	173/7206	0.00095584992643
ko00590	Arachidonic acid metabolism	1/1226	52/7206	0.00125187608409
ko00240	Pyrimidine metabolism	7/1226	110/7206	0.00130110766862
ko04964	Proximal tubule bicarbonate reclamation	12/1226	29/7206	0.00168703431884
ko04371	Apelin signaling pathway	46/1226	177/7206	0.00224045542743
ko05166	HTLV-I infection	31/1226	292/7206	0.00242035749594
ko03420	Nucleotide excision repair	1/1226	46/7206	0.00284399109588
ko01524	Platinum drug resistance	4/1226	76/7206	0.00330164073709
ko04612	Antigen processing and presentation	4/1226	77/7206	0.00332618215861
ko05321	Inflammatory bowel disease (IBD)	2/1226	56/7206	0.00375340364025
ko05145	Toxoplasmosis	10/1226	126/7206	0.00399857116032
ko03022	Basal transcription factors	1/1226	44/7206	0.00426695277175
ko05144	Malaria	1/1226	45/7206	0.00434711771197
ko00071	Fatty acid degradation	1/1226	45/7206	0.00434711771197
ko04912	GnRH signaling pathway	33/1226	122/7206	0.00487603774689
ko03018	RNA degradation	5/1226	84/7206	0.00492675238446
ko04923	Regulation of lipolysis in adipocytes	23/1226	77/7206	0.00533689986545
ko04622	RIG-I-like receptor signaling pathway	3/1226	62/7206	0.0062576005671
ko04214	Apoptosis - fly	4/1226	72/7206	0.00668157664435
ko00310	Lysine degradation	4/1226	73/7206	0.00689546432137
ko04658	Th1 and Th2 cell differentiation	7/1226	96/7206	0.00877738733028
ko04657	IL-17 signaling pathway	6/1226	87/7206	0.00915357428076
ko05418	Fluid shear stress and atherosclerosis	17/1226	173/7206	0.0100774095923
ko04350	TGF-beta signaling pathway	8/1226	103/7206	0.0113183438477
ko00260	Glycine, serine and threonine metabolism	2/1226	48/7206	0.0117814889367
ko04916	Melanogenesis	36/1226	142/7206	0.0124832777204
ko04630	Jak-STAT signaling pathway	12/1226	132/7206	0.0135337476408
ko05034	Alcoholism	55/1226	238/7206	0.0138226079754
ko00630	Glyoxylate and dicarboxylate metabolism	1/1226	38/7206	0.0149397495958
ko03410	Base excision repair	1/1226	38/7206	0.0149397495958
ko04620	Toll-like receptor signaling pathway	8/1226	100/7206	0.0150139239134
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1226	182/7206	0.0160991808806
ko05131	Shigellosis	6/1226	82/7206	0.0171244729666
ko04115	p53 signaling pathway	5/1226	74/7206	0.0183242357395
ko04640	Hematopoietic cell lineage	4/1226	64/7206	0.0183973629367
ko00600	Sphingolipid metabolism	4/1226	63/7206	0.0184025261388
ko04668	TNF signaling pathway	11/1226	120/7206	0.0194403897692
ko04140	Autophagy - animal	17/1226	164/7206	0.0204448221981
ko05133	Pertussis	7/1226	87/7206	0.0214670196042
ko00860	Porphyrin and chlorophyll metabolism	1/1226	34/7206	0.0217074949213
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1226	100/7206	0.0219140773066
ko05222	Small cell lung cancer	7/1226	89/7206	0.0219343575255
ko04015	Rap1 signaling pathway	62/1226	278/7206	0.022278476715
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1226	92/7206	0.0249914290856
ko00330	Arginine and proline metabolism	4/1226	61/7206	0.0255665360405
ko04330	Notch signaling pathway	4/1226	62/7206	0.0258392377924
ko05231	Choline metabolism in cancer	33/1226	134/7206	0.0265699854368
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1226	15/7206	0.0299329620107
ko05217	Basal cell carcinoma	5/1226	68/7206	0.0337364735276
ko04210	Apoptosis	20/1226	180/7206	0.0343695619979
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1226	135/7206	0.037201278454
ko05212	Pancreatic cancer	7/1226	83/7206	0.0385092352001
ko04270	Vascular smooth muscle contraction	36/1226	154/7206	0.0390778419329
ko05215	Prostate cancer	11/1226	111/7206	0.0420391807494
ko04918	Thyroid hormone synthesis	22/1226	86/7206	0.042153035077
ko05206	MicroRNAs in cancer	20/1226	177/7206	0.0423426509284
ko01200	Carbon metabolism	13/1226	128/7206	0.0425919828627
ko04930	Type II diabetes mellitus	15/1226	54/7206	0.0440844322635
ko05320	Autoimmune thyroid disease	1/1226	29/7206	0.048336471987