ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1169	423/7206	3.08722202372e-57
ko04724	Glutamatergic synapse	89/1169	152/7206	3.81538767099e-33
ko05033	Nicotine addiction	49/1169	56/7206	6.0671023618e-32
ko05032	Morphine addiction	69/1169	110/7206	1.79361613926e-28
ko04727	GABAergic synapse	67/1169	110/7206	1.39416891894e-26
ko04713	Circadian entrainment	74/1169	136/7206	6.23322879293e-25
ko04721	Synaptic vesicle cycle	52/1169	80/7206	8.83593478432e-23
ko04728	Dopaminergic synapse	85/1169	185/7206	6.14206632605e-22
ko04725	Cholinergic synapse	74/1169	160/7206	1.96119823471e-19
ko04723	Retrograde endocannabinoid signaling	78/1169	175/7206	3.18995347616e-19
ko04024	cAMP signaling pathway	103/1169	279/7206	1.37168126977e-17
ko04742	Taste transduction	39/1169	61/7206	5.14281886316e-17
ko04911	Insulin secretion	57/1169	117/7206	1.61459271274e-16
ko04020	Calcium signaling pathway	97/1169	265/7206	2.2646703283e-16
ko04726	Serotonergic synapse	59/1169	137/7206	5.31750037876e-14
ko04744	Phototransduction	26/1169	36/7206	1.10666345443e-13
ko04921	Oxytocin signaling pathway	77/1169	209/7206	2.29401901927e-13
ko04740	Olfactory transduction	40/1169	80/7206	1.95083033787e-12
ko04261	Adrenergic signaling in cardiomyocytes	73/1169	205/7206	6.79766518246e-12
ko05031	Amphetamine addiction	42/1169	91/7206	1.58567503449e-11
ko04720	Long-term potentiation	44/1169	99/7206	2.52093600992e-11
ko04970	Salivary secretion	42/1169	95/7206	8.84112174773e-11
ko03040	Spliceosome	1/1169	145/7206	3.19999294633e-10
ko05203	Viral carcinogenesis	14/1169	277/7206	9.68117104101e-09
ko04360	Axon guidance	72/1169	233/7206	1.2766993246e-08
ko04060	Cytokine-cytokine receptor interaction	7/1169	191/7206	7.08626661511e-08
ko05030	Cocaine addiction	31/1169	73/7206	8.26462816069e-08
ko04022	cGMP-PKG signaling pathway	66/1169	216/7206	9.39312732354e-08
ko04925	Aldosterone synthesis and secretion	39/1169	105/7206	1.53940296928e-07
ko05164	Influenza A	6/1169	167/7206	3.55089782608e-07
ko04971	Gastric acid secretion	36/1169	98/7206	6.29968457872e-07
ko05322	Systemic lupus erythematosus	5/1169	151/7206	9.08767346367e-07
ko04120	Ubiquitin mediated proteolysis	4/1169	138/7206	9.65690106894e-07
ko03013	RNA transport	7/1169	166/7206	1.89221264017e-06
ko04924	Renin secretion	32/1169	86/7206	2.05521866791e-06
ko05168	Herpes simplex infection	9/1169	182/7206	3.42851841863e-06
ko04514	Cell adhesion molecules (CAMs)	42/1169	130/7206	5.36828256664e-06
ko04010	MAPK signaling pathway	83/1169	321/7206	6.07637298914e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1169	74/7206	7.41518261826e-06
ko04141	Protein processing in endoplasmic reticulum	10/1169	184/7206	1.02522240758e-05
ko04966	Collecting duct acid secretion	14/1169	26/7206	1.13610552974e-05
ko04972	Pancreatic secretion	36/1169	111/7206	2.13756294344e-05
ko04621	NOD-like receptor signaling pathway	8/1169	157/7206	2.5313067503e-05
ko04540	Gap junction	40/1169	128/7206	2.68938719333e-05
ko04745	Phototransduction - fly	17/1169	38/7206	3.16171380802e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1169	79/7206	3.59774863944e-05
ko04260	Cardiac muscle contraction	32/1169	98/7206	4.66563597207e-05
ko04730	Long-term depression	27/1169	78/7206	6.72518198819e-05
ko05110	Vibrio cholerae infection	23/1169	63/7206	8.59172167403e-05
ko04110	Cell cycle	8/1169	145/7206	0.000140571334209
ko05414	Dilated cardiomyopathy	34/1169	112/7206	0.000149386857044
ko04070	Phosphatidylinositol signaling system	34/1169	112/7206	0.000149386857044
ko05169	Epstein-Barr virus infection	15/1169	206/7206	0.000165139957233
ko04610	Complement and coagulation cascades	2/1169	79/7206	0.00017205850532
ko03008	Ribosome biogenesis in eukaryotes	2/1169	79/7206	0.00017205850532
ko05205	Proteoglycans in cancer	23/1169	271/7206	0.000204020619582
ko05162	Measles	6/1169	120/7206	0.000245425025682
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1169	59/7206	0.000250927126064
ko04612	Antigen processing and presentation	2/1169	77/7206	0.000257559551244
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1169	182/7206	0.000331584641276
ko04014	Ras signaling pathway	68/1169	279/7206	0.000342695906581
ko05140	Leishmaniasis	2/1169	75/7206	0.000389111534769
ko04064	NF-kappa B signaling pathway	4/1169	96/7206	0.000404422743135
ko04750	Inflammatory mediator regulation of TRP channels	35/1169	122/7206	0.000449465497444
ko04976	Bile secretion	25/1169	80/7206	0.000682385657559
ko04072	Phospholipase D signaling pathway	50/1169	197/7206	0.00080301153556
ko05161	Hepatitis B	13/1169	173/7206	0.00109396410267
ko04146	Peroxisome	4/1169	89/7206	0.00121504351835
ko00240	Pyrimidine metabolism	7/1169	110/7206	0.00259428655906
ko00330	Arginine and proline metabolism	2/1169	61/7206	0.00266077479051
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1169	14/7206	0.00347439124307
ko03420	Nucleotide excision repair	1/1169	46/7206	0.00444199219096
ko05418	Fluid shear stress and atherosclerosis	15/1169	173/7206	0.00467320383289
ko04657	IL-17 signaling pathway	5/1169	87/7206	0.00501591932069
ko04371	Apelin signaling pathway	43/1169	177/7206	0.00506692850622
ko04140	Autophagy - animal	14/1169	164/7206	0.00515394846439
ko04210	Apoptosis	16/1169	180/7206	0.00547497682732
ko04630	Jak-STAT signaling pathway	10/1169	132/7206	0.0056893201044
ko05321	Inflammatory bowel disease (IBD)	2/1169	56/7206	0.00571966804281
ko05215	Prostate cancer	8/1169	111/7206	0.00632278266315
ko03022	Basal transcription factors	1/1169	44/7206	0.00668363368176
ko05144	Malaria	1/1169	45/7206	0.00690409362169
ko00071	Fatty acid degradation	1/1169	45/7206	0.00690409362169
ko03018	RNA degradation	5/1169	84/7206	0.00696884220973
ko04217	Necroptosis	16/1169	178/7206	0.00710428132895
ko04923	Regulation of lipolysis in adipocytes	22/1169	77/7206	0.00730122642049
ko05166	HTLV-I infection	31/1169	292/7206	0.00730249995781
ko04915	Estrogen signaling pathway	33/1169	131/7206	0.00802951523753
ko00480	Glutathione metabolism	2/1169	55/7206	0.00873920288395
ko04620	Toll-like receptor signaling pathway	7/1169	100/7206	0.00901631621945
ko04640	Hematopoietic cell lineage	3/1169	64/7206	0.00948989108064
ko04214	Apoptosis - fly	4/1169	72/7206	0.00965917874158
ko05131	Shigellosis	5/1169	82/7206	0.00972109718591
ko00310	Lysine degradation	4/1169	73/7206	0.00977254068958
ko05145	Toxoplasmosis	10/1169	126/7206	0.00988494379818
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1169	100/7206	0.0130188587769
ko04622	RIG-I-like receptor signaling pathway	3/1169	62/7206	0.0138386720206
ko00630	Glyoxylate and dicarboxylate metabolism	1/1169	38/7206	0.0149850924759
ko03410	Base excision repair	1/1169	38/7206	0.0149850924759
ko04658	Th1 and Th2 cell differentiation	7/1169	96/7206	0.0167850881304
ko04668	TNF signaling pathway	10/1169	120/7206	0.0169999798097
ko00260	Glycine, serine and threonine metabolism	2/1169	48/7206	0.0176430543692
ko05219	Bladder cancer	2/1169	48/7206	0.0176430543692
ko04626	Plant-pathogen interaction	7/1169	18/7206	0.0177967188686
ko05133	Pertussis	6/1169	87/7206	0.0180111682263
ko01524	Platinum drug resistance	5/1169	76/7206	0.0183815008591
ko04964	Proximal tubule bicarbonate reclamation	10/1169	29/7206	0.0184758833247
ko00380	Tryptophan metabolism	2/1169	50/7206	0.0185971250786
ko04115	p53 signaling pathway	5/1169	74/7206	0.0253311649418
ko04918	Thyroid hormone synthesis	22/1169	86/7206	0.0259862047914
ko04930	Type II diabetes mellitus	15/1169	54/7206	0.0262833338288
ko05222	Small cell lung cancer	7/1169	89/7206	0.029450816257
ko04218	Cellular senescence	18/1169	177/7206	0.029483540555
ko05206	MicroRNAs in cancer	18/1169	177/7206	0.029483540555
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1169	92/7206	0.0313427957985
ko00860	Porphyrin and chlorophyll metabolism	1/1169	34/7206	0.0334397519242
ko04912	GnRH signaling pathway	29/1169	122/7206	0.0341129235407
ko04270	Vascular smooth muscle contraction	35/1169	154/7206	0.0349818366396
ko00590	Arachidonic acid metabolism	3/1169	52/7206	0.0373657441077
ko00280	Valine, leucine and isoleucine degradation	3/1169	54/7206	0.0388066568646
ko05016	Huntington's disease	24/1169	215/7206	0.0389899870555
ko00562	Inositol phosphate metabolism	22/1169	89/7206	0.0411489505182
ko04350	TGF-beta signaling pathway	9/1169	103/7206	0.0422134278832
ko03320	PPAR signaling pathway	5/1169	69/7206	0.0471488605349
ko04916	Melanogenesis	32/1169	142/7206	0.0496599643657