ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	199/1093	423/7206	1.06445372004e-58
ko05033	Nicotine addiction	50/1093	56/7206	5.44028691369e-35
ko04724	Glutamatergic synapse	88/1093	152/7206	1.37989864193e-34
ko04713	Circadian entrainment	74/1093	136/7206	7.83012812564e-27
ko04727	GABAergic synapse	65/1093	110/7206	1.79725327284e-26
ko05032	Morphine addiction	65/1093	110/7206	1.79725327284e-26
ko04728	Dopaminergic synapse	83/1093	185/7206	1.39218345798e-22
ko04721	Synaptic vesicle cycle	50/1093	80/7206	3.65517396215e-22
ko04725	Cholinergic synapse	74/1093	160/7206	3.31563244255e-21
ko04723	Retrograde endocannabinoid signaling	75/1093	175/7206	4.60573700396e-19
ko04024	cAMP signaling pathway	101/1093	279/7206	9.9154664824e-19
ko04911	Insulin secretion	56/1093	117/7206	3.63816126192e-17
ko04020	Calcium signaling pathway	93/1093	265/7206	2.68534211605e-16
ko05031	Amphetamine addiction	45/1093	91/7206	1.05894950117e-14
ko04742	Taste transduction	35/1093	61/7206	2.92976817913e-14
ko04726	Serotonergic synapse	57/1093	137/7206	4.42115588537e-14
ko04921	Oxytocin signaling pathway	75/1093	209/7206	7.86522358621e-14
ko04720	Long-term potentiation	46/1093	99/7206	1.01469647995e-13
ko04261	Adrenergic signaling in cardiomyocytes	71/1093	205/7206	2.85547673131e-12
ko04970	Salivary secretion	42/1093	95/7206	9.4792907737e-12
ko04744	Phototransduction	22/1093	36/7206	3.52501091334e-10
ko05030	Cocaine addiction	33/1093	73/7206	7.99353599362e-10
ko03040	Spliceosome	1/1093	145/7206	1.37116619727e-09
ko04360	Axon guidance	70/1093	233/7206	4.31819689865e-09
ko04925	Aldosterone synthesis and secretion	40/1093	105/7206	6.39692140625e-09
ko04010	MAPK signaling pathway	88/1093	321/7206	9.56244610479e-09
ko05203	Viral carcinogenesis	13/1093	277/7206	2.97997398278e-08
ko04971	Gastric acid secretion	37/1093	98/7206	3.13551174195e-08
ko05168	Herpes simplex infection	5/1093	182/7206	4.64296029852e-08
ko04022	cGMP-PKG signaling pathway	63/1093	216/7206	1.12637103158e-07
ko04740	Olfactory transduction	31/1093	80/7206	2.07686484732e-07
ko04060	Cytokine-cytokine receptor interaction	7/1093	191/7206	3.46665429213e-07
ko04924	Renin secretion	32/1093	86/7206	3.94760681366e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1093	74/7206	1.41605588895e-06
ko05322	Systemic lupus erythematosus	5/1093	151/7206	3.04975281227e-06
ko04540	Gap junction	40/1093	128/7206	4.27680502017e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1093	59/7206	6.84660369604e-06
ko04730	Long-term depression	28/1093	78/7206	7.22868218254e-06
ko03013	RNA transport	7/1093	166/7206	8.9434055241e-06
ko04972	Pancreatic secretion	35/1093	111/7206	1.18509512742e-05
ko04014	Ras signaling pathway	69/1093	279/7206	1.84589912582e-05
ko04120	Ubiquitin mediated proteolysis	5/1093	138/7206	1.95557750225e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1093	79/7206	2.18787991653e-05
ko04966	Collecting duct acid secretion	13/1093	26/7206	3.15616540375e-05
ko04260	Cardiac muscle contraction	31/1093	98/7206	4.41360078217e-05
ko04141	Protein processing in endoplasmic reticulum	10/1093	184/7206	6.10258186655e-05
ko04612	Antigen processing and presentation	1/1093	77/7206	7.9503128435e-05
ko05110	Vibrio cholerae infection	22/1093	63/7206	0.000109348733397
ko05164	Influenza A	9/1093	167/7206	0.000111523226942
ko04072	Phospholipase D signaling pathway	50/1093	197/7206	0.0001653687358
ko04514	Cell adhesion molecules (CAMs)	36/1093	130/7206	0.000186036039842
ko04745	Phototransduction - fly	15/1093	38/7206	0.000232165933364
ko05414	Dilated cardiomyopathy	32/1093	112/7206	0.000261853603639
ko04070	Phosphatidylinositol signaling system	32/1093	112/7206	0.000261853603639
ko04915	Estrogen signaling pathway	36/1093	131/7206	0.000291530655708
ko05169	Epstein-Barr virus infection	14/1093	206/7206	0.000343326985395
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1093	14/7206	0.000348765664025
ko03008	Ribosome biogenesis in eukaryotes	2/1093	79/7206	0.0004097250766
ko04621	NOD-like receptor signaling pathway	9/1093	157/7206	0.000415311434094
ko00240	Pyrimidine metabolism	5/1093	110/7206	0.000693544763513
ko04750	Inflammatory mediator regulation of TRP channels	33/1093	122/7206	0.000779974884062
ko05205	Proteoglycans in cancer	23/1093	271/7206	0.00131701262824
ko04110	Cell cycle	9/1093	145/7206	0.00142099472523
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1093	182/7206	0.00154138875436
ko04976	Bile secretion	23/1093	80/7206	0.00154573035582
ko04015	Rap1 signaling pathway	61/1093	278/7206	0.00207096050094
ko00480	Glutathione metabolism	1/1093	55/7206	0.00208737227209
ko04146	Peroxisome	4/1093	89/7206	0.00258388648089
ko04371	Apelin signaling pathway	42/1093	177/7206	0.00274378198682
ko05162	Measles	7/1093	120/7206	0.00281938364714
ko04912	GnRH signaling pathway	31/1093	122/7206	0.00307271328376
ko00590	Arachidonic acid metabolism	1/1093	52/7206	0.00312419938956
ko05140	Leishmaniasis	3/1093	75/7206	0.00332503537471
ko04064	NF-kappa B signaling pathway	5/1093	96/7206	0.00379380620017
ko04640	Hematopoietic cell lineage	2/1093	64/7206	0.00426255244053
ko04214	Apoptosis - fly	3/1093	72/7206	0.00477382410103
ko03018	RNA degradation	4/1093	84/7206	0.00522468147069
ko04350	TGF-beta signaling pathway	6/1093	103/7206	0.00525626016697
ko04923	Regulation of lipolysis in adipocytes	21/1093	77/7206	0.00585175399508
ko05214	Glioma	21/1093	79/7206	0.00710957546686
ko00260	Glycine, serine and threonine metabolism	1/1093	48/7206	0.0072149858038
ko04140	Autophagy - animal	13/1093	164/7206	0.00781361415719
ko04964	Proximal tubule bicarbonate reclamation	10/1093	29/7206	0.00790476073036
ko05145	Toxoplasmosis	9/1093	126/7206	0.00829767253605
ko04973	Carbohydrate digestion and absorption	13/1093	42/7206	0.00832721271123
ko04916	Melanogenesis	33/1093	142/7206	0.00920929481246
ko04657	IL-17 signaling pathway	5/1093	87/7206	0.0100948361096
ko03022	Basal transcription factors	1/1093	44/7206	0.0104344511474
ko05144	Malaria	1/1093	45/7206	0.0106431405819
ko00071	Fatty acid degradation	1/1093	45/7206	0.0106431405819
ko03420	Nucleotide excision repair	1/1093	46/7206	0.0111701206823
ko04626	Plant-pathogen interaction	7/1093	18/7206	0.0124425575452
ko05321	Inflammatory bowel disease (IBD)	2/1093	56/7206	0.013234043953
ko05231	Choline metabolism in cancer	31/1093	134/7206	0.0143537207466
ko00983	Drug metabolism - other enzymes	1/1093	42/7206	0.015718947844
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1093	100/7206	0.0169226941123
ko01200	Carbon metabolism	10/1093	128/7206	0.0175803999834
ko04217	Necroptosis	16/1093	178/7206	0.0194248142074
ko00330	Arginine and proline metabolism	3/1093	61/7206	0.0194844063485
ko04622	RIG-I-like receptor signaling pathway	3/1093	62/7206	0.0195710987582
ko04930	Type II diabetes mellitus	15/1093	54/7206	0.0198601077167
ko05034	Alcoholism	49/1093	238/7206	0.0213806312063
ko04270	Vascular smooth muscle contraction	34/1093	154/7206	0.0223680151948
ko00630	Glyoxylate and dicarboxylate metabolism	1/1093	38/7206	0.0231343922128
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1093	40/7206	0.0239626461121
ko05166	HTLV-I infection	31/1093	292/7206	0.0245937385029
ko04630	Jak-STAT signaling pathway	11/1093	132/7206	0.026802586936
ko03320	PPAR signaling pathway	4/1093	69/7206	0.0272231557317
ko05418	Fluid shear stress and atherosclerosis	16/1093	173/7206	0.0311073199034
ko05161	Hepatitis B	16/1093	173/7206	0.0311073199034
ko00512	Mucin type O-glycan biosynthesis	9/1093	29/7206	0.0320303996522
ko00982	Drug metabolism - cytochrome P450	1/1093	37/7206	0.0351469953702
ko01524	Platinum drug resistance	5/1093	76/7206	0.0355232997917
ko00620	Pyruvate metabolism	2/1093	46/7206	0.0379886898464
ko05131	Shigellosis	6/1093	82/7206	0.0441307627917
ko04137	Mitophagy - animal	6/1093	82/7206	0.0441307627917
ko04071	Sphingolipid signaling pathway	34/1093	162/7206	0.0453338803937
ko04922	Glucagon signaling pathway	28/1093	128/7206	0.0453918166714
ko04960	Aldosterone-regulated sodium reabsorption	11/1093	41/7206	0.0473789522831
ko04918	Thyroid hormone synthesis	20/1093	86/7206	0.0475264499434
ko00310	Lysine degradation	5/1093	73/7206	0.0480153897142
ko04620	Toll-like receptor signaling pathway	8/1093	100/7206	0.0481566312583
ko04115	p53 signaling pathway	5/1093	74/7206	0.0486403262018