ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	208/1233	423/7206	5.37262418598e-56
ko04724	Glutamatergic synapse	86/1233	152/7206	9.33623340176e-29
ko05033	Nicotine addiction	46/1233	56/7206	1.60779906757e-26
ko04713	Circadian entrainment	77/1233	136/7206	7.260117859e-26
ko05032	Morphine addiction	67/1233	110/7206	3.49750719728e-25
ko04727	GABAergic synapse	64/1233	110/7206	1.46898799346e-22
ko04728	Dopaminergic synapse	85/1233	185/7206	2.34252121768e-20
ko04725	Cholinergic synapse	76/1233	160/7206	2.27278579624e-19
ko04020	Calcium signaling pathway	104/1233	265/7206	2.28109281264e-18
ko04024	cAMP signaling pathway	107/1233	279/7206	8.2658772582e-18
ko04721	Synaptic vesicle cycle	47/1233	80/7206	4.05577633555e-17
ko04723	Retrograde endocannabinoid signaling	76/1233	175/7206	1.3688157359e-16
ko04911	Insulin secretion	58/1233	117/7206	3.95144926084e-16
ko04744	Phototransduction	28/1233	36/7206	1.93601358772e-15
ko04726	Serotonergic synapse	62/1233	137/7206	9.08901903259e-15
ko04742	Taste transduction	37/1233	61/7206	2.29564377486e-14
ko04921	Oxytocin signaling pathway	79/1233	209/7206	4.22521163331e-13
ko04261	Adrenergic signaling in cardiomyocytes	76/1233	205/7206	4.83898356303e-12
ko04970	Salivary secretion	43/1233	95/7206	1.22080691767e-10
ko04740	Olfactory transduction	38/1233	80/7206	2.58556402146e-10
ko03040	Spliceosome	2/1233	145/7206	9.59787158612e-10
ko05203	Viral carcinogenesis	14/1233	277/7206	1.48467090452e-09
ko05031	Amphetamine addiction	39/1233	91/7206	6.18372142469e-09
ko04720	Long-term potentiation	41/1233	99/7206	8.54126941738e-09
ko04022	cGMP-PKG signaling pathway	70/1233	216/7206	2.23736274846e-08
ko04925	Aldosterone synthesis and secretion	41/1233	105/7206	6.57360974258e-08
ko05322	Systemic lupus erythematosus	5/1233	151/7206	1.64237151476e-07
ko04060	Cytokine-cytokine receptor interaction	9/1233	191/7206	2.55993892431e-07
ko03013	RNA transport	7/1233	166/7206	5.72863760339e-07
ko04360	Axon guidance	70/1233	233/7206	8.11052255595e-07
ko04971	Gastric acid secretion	37/1233	98/7206	9.40589000552e-07
ko05168	Herpes simplex infection	10/1233	182/7206	3.33972363316e-06
ko05030	Cocaine addiction	29/1233	73/7206	4.61638338201e-06
ko04070	Phosphatidylinositol signaling system	39/1233	112/7206	5.47523886157e-06
ko04514	Cell adhesion molecules (CAMs)	43/1233	130/7206	8.82992954772e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1233	74/7206	1.65345159428e-05
ko05164	Influenza A	10/1233	167/7206	2.56705240198e-05
ko04010	MAPK signaling pathway	84/1233	321/7206	2.75675521602e-05
ko04972	Pancreatic secretion	37/1233	111/7206	3.21571600328e-05
ko04976	Bile secretion	29/1233	80/7206	3.36135585317e-05
ko04621	NOD-like receptor signaling pathway	9/1233	157/7206	3.58305710456e-05
ko04730	Long-term depression	28/1233	78/7206	5.51594705014e-05
ko04745	Phototransduction - fly	17/1233	38/7206	6.40635513589e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1233	79/7206	6.84971435604e-05
ko04540	Gap junction	40/1233	128/7206	7.25952303397e-05
ko04072	Phospholipase D signaling pathway	55/1233	197/7206	0.000112775778176
ko03008	Ribosome biogenesis in eukaryotes	2/1233	79/7206	0.000113366040439
ko04110	Cell cycle	9/1233	145/7206	0.000131916143188
ko04120	Ubiquitin mediated proteolysis	8/1233	138/7206	0.000132576413574
ko05140	Leishmaniasis	2/1233	75/7206	0.000159950937466
ko04260	Cardiac muscle contraction	32/1233	98/7206	0.000196645360056
ko04141	Protein processing in endoplasmic reticulum	14/1233	184/7206	0.000219180853433
ko05205	Proteoglycans in cancer	25/1233	271/7206	0.000271014989789
ko05169	Epstein-Barr virus infection	17/1233	206/7206	0.000324271146689
ko04924	Renin secretion	28/1233	86/7206	0.000427957713304
ko04966	Collecting duct acid secretion	12/1233	26/7206	0.000545406304578
ko04750	Inflammatory mediator regulation of TRP channels	36/1233	122/7206	0.000600553754722
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1233	59/7206	0.00067053482819
ko04612	Antigen processing and presentation	3/1233	77/7206	0.000674398548262
ko04371	Apelin signaling pathway	48/1233	177/7206	0.000770677879139
ko00520	Amino sugar and nucleotide sugar metabolism	1/1233	55/7206	0.000859052113142
ko04064	NF-kappa B signaling pathway	5/1233	96/7206	0.000881541161488
ko04923	Regulation of lipolysis in adipocytes	25/1233	77/7206	0.00110310376017
ko00240	Pyrimidine metabolism	7/1233	110/7206	0.00129081308001
ko05414	Dilated cardiomyopathy	33/1233	112/7206	0.0013554321756
ko04014	Ras signaling pathway	68/1233	279/7206	0.00153026489448
ko05161	Hepatitis B	15/1233	173/7206	0.00202264029518
ko04610	Complement and coagulation cascades	4/1233	79/7206	0.00232084098573
ko04657	IL-17 signaling pathway	5/1233	87/7206	0.00243587445611
ko04658	Th1 and Th2 cell differentiation	6/1233	96/7206	0.00248293415107
ko04146	Peroxisome	5/1233	89/7206	0.00253589746573
ko03420	Nucleotide excision repair	1/1233	46/7206	0.00281801669935
ko05162	Measles	9/1233	120/7206	0.00313704432017
ko04930	Type II diabetes mellitus	18/1233	54/7206	0.0032175518784
ko00480	Glutathione metabolism	2/1233	55/7206	0.00373927226461
ko05321	Inflammatory bowel disease (IBD)	2/1233	56/7206	0.00375213283672
ko05110	Vibrio cholerae infection	20/1233	63/7206	0.0038390725979
ko04710	Circadian rhythm	15/1233	43/7206	0.00401720644478
ko03022	Basal transcription factors	1/1233	44/7206	0.00424895176302
ko04640	Hematopoietic cell lineage	3/1233	64/7206	0.00433524166798
ko05144	Malaria	1/1233	45/7206	0.00437422660431
ko00071	Fatty acid degradation	1/1233	45/7206	0.00437422660431
ko00310	Lysine degradation	4/1233	73/7206	0.00466499368609
ko04270	Vascular smooth muscle contraction	40/1233	154/7206	0.00474670946239
ko04915	Estrogen signaling pathway	35/1233	131/7206	0.0048131484115
ko04622	RIG-I-like receptor signaling pathway	3/1233	62/7206	0.00622520690091
ko04626	Plant-pathogen interaction	8/1233	18/7206	0.00623184834526
ko05166	HTLV-I infection	33/1233	292/7206	0.00680289886174
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1233	100/7206	0.00685894883746
ko00590	Arachidonic acid metabolism	2/1233	52/7206	0.00832932772397
ko04142	Lysosome	14/1233	151/7206	0.00841311402826
ko05133	Pertussis	6/1233	87/7206	0.00919647244262
ko00330	Arginine and proline metabolism	3/1233	61/7206	0.00923704985796
ko04964	Proximal tubule bicarbonate reclamation	11/1233	29/7206	0.0103391994602
ko04217	Necroptosis	18/1233	178/7206	0.0113716581814
ko03018	RNA degradation	6/1233	84/7206	0.0124928063995
ko04115	p53 signaling pathway	5/1233	74/7206	0.0129254517531
ko04711	Circadian rhythm - fly	6/1233	13/7206	0.0143007285055
ko03410	Base excision repair	1/1233	38/7206	0.0150481044574
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1233	182/7206	0.0162265358211
ko05131	Shigellosis	6/1233	82/7206	0.0172127319952
ko00280	Valine, leucine and isoleucine degradation	3/1233	54/7206	0.0182007388209
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1233	14/7206	0.02146772827
ko05215	Prostate cancer	10/1233	111/7206	0.0215562336757
ko00860	Porphyrin and chlorophyll metabolism	1/1233	34/7206	0.0216117428674
ko00562	Inositol phosphate metabolism	24/1233	89/7206	0.0221769358758
ko04113	Meiosis - yeast	5/1233	70/7206	0.0245459313161
ko04630	Jak-STAT signaling pathway	13/1233	132/7206	0.0259668403515
ko04620	Toll-like receptor signaling pathway	9/1233	100/7206	0.0314126055793
ko01200	Carbon metabolism	13/1233	128/7206	0.0329859697349
ko05016	Huntington's disease	25/1233	215/7206	0.0338997722384
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1233	40/7206	0.0359611222678
ko00380	Tryptophan metabolism	3/1233	50/7206	0.0365941403843
ko05012	Parkinson's disease	17/1233	155/7206	0.0402203037009
ko04922	Glucagon signaling pathway	31/1233	128/7206	0.0430069642761
ko04918	Thyroid hormone synthesis	22/1233	86/7206	0.0430558440132
ko04722	Neurotrophin signaling pathway	37/1233	160/7206	0.0439885623581
ko05231	Choline metabolism in cancer	32/1233	134/7206	0.047951890982
ko05320	Autoimmune thyroid disease	1/1233	29/7206	0.0481564148871