ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 31/368 80/7206 3.79085292651e-20 ko04724 Glutamatergic synapse 40/368 152/7206 1.23885433539e-18 ko05033 Nicotine addiction 23/368 56/7206 6.64942362561e-16 ko04713 Circadian entrainment 30/368 136/7206 4.64249862497e-12 ko04728 Dopaminergic synapse 35/368 185/7206 8.10944931805e-12 ko04727 GABAergic synapse 26/368 110/7206 2.49144839539e-11 ko04723 Retrograde endocannabinoid signaling 32/368 175/7206 1.69218529552e-10 ko04911 Insulin secretion 25/368 117/7206 6.16463224673e-10 ko04080 Neuroactive ligand-receptor interaction 53/368 423/7206 6.57424704145e-10 ko05032 Morphine addiction 24/368 110/7206 8.7424421708e-10 ko04966 Collecting duct acid secretion 11/368 26/7206 2.05427362464e-08 ko04261 Adrenergic signaling in cardiomyocytes 30/368 205/7206 1.36038334795e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 16/368 74/7206 6.84678485531e-07 ko04970 Salivary secretion 18/368 95/7206 1.09728093366e-06 ko04024 cAMP signaling pathway 34/368 279/7206 1.9866150188e-06 ko05110 Vibrio cholerae infection 14/368 63/7206 2.42917941265e-06 ko05031 Amphetamine addiction 17/368 91/7206 2.68675056081e-06 ko05030 Cocaine addiction 15/368 73/7206 3.03210420627e-06 ko04744 Phototransduction 10/368 36/7206 8.22591240793e-06 ko04720 Long-term potentiation 17/368 99/7206 8.86027813635e-06 ko05120 Epithelial cell signaling in Helicobacter pylori infection 16/368 92/7206 1.37871361454e-05 ko04726 Serotonergic synapse 20/368 137/7206 1.82859244585e-05 ko04725 Cholinergic synapse 22/368 160/7206 1.85030669358e-05 ko04514 Cell adhesion molecules (CAMs) 18/368 130/7206 9.73461494957e-05 ko04730 Long-term depression 13/368 78/7206 0.000139105947931 ko04972 Pancreatic secretion 16/368 111/7206 0.000146500416266 ko04921 Oxytocin signaling pathway 24/368 209/7206 0.000166252404199 ko05010 Alzheimer's disease 23/368 202/7206 0.00025715099798 ko04260 Cardiac muscle contraction 14/368 98/7206 0.000414926015062 ko05323 Rheumatoid arthritis 13/368 89/7206 0.000532979342667 ko05205 Proteoglycans in cancer 3/368 271/7206 0.000628778812914 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/368 59/7206 0.000710561269418 ko04060 Cytokine-cytokine receptor interaction 1/368 191/7206 0.000724621443759 ko04022 cGMP-PKG signaling pathway 23/368 216/7206 0.000752282704179 ko04924 Renin secretion 12/368 86/7206 0.00130783187776 ko05168 Herpes simplex infection 1/368 182/7206 0.00163955848289 ko04145 Phagosome 18/368 162/7206 0.00165564454112 ko05203 Viral carcinogenesis 4/368 277/7206 0.00199992332364 ko04510 Focal adhesion 3/368 240/7206 0.00253062861883 ko04010 MAPK signaling pathway 29/368 321/7206 0.00254339912386 ko04020 Calcium signaling pathway 25/368 265/7206 0.002569083921 ko04964 Proximal tubule bicarbonate reclamation 6/368 29/7206 0.00297216378732 ko00190 Oxidative phosphorylation 15/368 127/7206 0.00316930692392 ko05164 Influenza A 1/368 167/7206 0.00352396759455 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/368 14/7206 0.00445088846461 ko03040 Spliceosome 1/368 145/7206 0.00699143310592 ko05322 Systemic lupus erythematosus 1/368 151/7206 0.00738882785072 ko04360 Axon guidance 21/368 233/7206 0.00965810293225 ko04120 Ubiquitin mediated proteolysis 1/368 138/7206 0.0101599020466 ko04745 Phototransduction - fly 6/368 38/7206 0.011739158603 ko04630 Jak-STAT signaling pathway 1/368 132/7206 0.0148665779832 ko04978 Mineral absorption 6/368 40/7206 0.0149874005903 ko05034 Alcoholism 21/368 238/7206 0.0151643545273 ko04960 Aldosterone-regulated sodium reabsorption 6/368 41/7206 0.0168249562245 ko00513 Various types of N-glycan biosynthesis 6/368 42/7206 0.0188119940243 ko04973 Carbohydrate digestion and absorption 6/368 42/7206 0.0188119940243 ko04940 Type I diabetes mellitus 5/368 32/7206 0.0218050466667 ko05166 HTLV-I infection 7/368 292/7206 0.0290977813911 ko04072 Phospholipase D signaling pathway 17/368 197/7206 0.0312821664044 ko04668 TNF signaling pathway 1/368 120/7206 0.0324268819151 ko04971 Gastric acid secretion 10/368 98/7206 0.0330178817948 ko04742 Taste transduction 7/368 61/7206 0.0347977951512 ko05169 Epstein-Barr virus infection 4/368 206/7206 0.035147922525 ko05161 Hepatitis B 3/368 173/7206 0.0354514304633 ko02024 Quorum sensing 3/368 15/7206 0.038029987859 ko05152 Tuberculosis 16/368 187/7206 0.041045403953 ko05215 Prostate cancer 1/368 111/7206 0.0458497468446 ko04550 Signaling pathways regulating pluripotency of stem cells 3/368 165/7206 0.0485376344099 ko04140 Autophagy - animal 3/368 164/7206 0.0485558647851