ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 64/510 145/7206 3.28551132233e-36 ko04110 Cell cycle 52/510 145/7206 2.54790723244e-24 ko03460 Fanconi anemia pathway 29/510 51/7206 7.4395477989e-21 ko03440 Homologous recombination 26/510 41/7206 1.58442923608e-20 ko04111 Cell cycle - yeast 37/510 90/7206 5.95499620959e-20 ko03013 RNA transport 47/510 166/7206 2.83564358133e-17 ko04113 Meiosis - yeast 28/510 70/7206 5.17857117276e-15 ko03030 DNA replication 19/510 38/7206 1.01254743645e-12 ko00240 Pyrimidine metabolism 32/510 110/7206 1.79059706837e-12 ko03008 Ribosome biogenesis in eukaryotes 26/510 79/7206 1.00906889659e-11 ko03022 Basal transcription factors 18/510 44/7206 2.70090398337e-10 ko03420 Nucleotide excision repair 17/510 46/7206 5.49338976746e-09 ko04144 Endocytosis 3/510 342/7206 5.51508697522e-08 ko03430 Mismatch repair 11/510 22/7206 6.91892106129e-08 ko03410 Base excision repair 14/510 38/7206 1.31558306006e-07 ko03018 RNA degradation 20/510 84/7206 1.02942629272e-06 ko03015 mRNA surveillance pathway 21/510 93/7206 1.40925214428e-06 ko04151 PI3K-Akt signaling pathway 8/510 390/7206 9.4669077591e-06 ko04114 Oocyte meiosis 25/510 139/7206 1.16609389266e-05 ko04060 Cytokine-cytokine receptor interaction 1/510 191/7206 2.03602013586e-05 ko04024 cAMP signaling pathway 4/510 279/7206 2.14769140866e-05 ko04914 Progesterone-mediated oocyte maturation 19/510 104/7206 0.000104693865159 ko03020 RNA polymerase 9/510 29/7206 0.000115393191494 ko05203 Viral carcinogenesis 37/510 277/7206 0.000166882719253 ko04510 Focal adhesion 4/510 240/7206 0.000174455310191 ko04022 cGMP-PKG signaling pathway 3/510 216/7206 0.000209022027465 ko04621 NOD-like receptor signaling pathway 1/510 157/7206 0.000211633656964 ko05152 Tuberculosis 2/510 187/7206 0.000224674667848 ko05166 HTLV-I infection 38/510 292/7206 0.00024695810278 ko04120 Ubiquitin mediated proteolysis 22/510 138/7206 0.000283209493352 ko04724 Glutamatergic synapse 1/510 152/7206 0.000314308958321 ko04270 Vascular smooth muscle contraction 1/510 154/7206 0.000328336830414 ko04261 Adrenergic signaling in cardiomyocytes 3/510 205/7206 0.000430724978592 ko04723 Retrograde endocannabinoid signaling 2/510 175/7206 0.000466914366758 ko05322 Systemic lupus erythematosus 23/510 151/7206 0.000530458193378 ko04218 Cellular senescence 25/510 177/7206 0.000858818673631 ko04713 Circadian entrainment 1/510 136/7206 0.00101336249516 ko04015 Rap1 signaling pathway 7/510 278/7206 0.00114393807785 ko04014 Ras signaling pathway 7/510 279/7206 0.001152681039 ko04728 Dopaminergic synapse 3/510 185/7206 0.00119691249721 ko05012 Parkinson's disease 2/510 155/7206 0.00138402020806 ko04921 Oxytocin signaling pathway 4/510 209/7206 0.00139387299867 ko00190 Oxidative phosphorylation 1/510 127/7206 0.00144191467003 ko01200 Carbon metabolism 1/510 128/7206 0.00144377932034 ko04530 Tight junction 5/510 228/7206 0.00147206146892 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/510 182/7206 0.00175443058269 ko04115 p53 signaling pathway 13/510 74/7206 0.00184112187592 ko04810 Regulation of actin cytoskeleton 7/510 264/7206 0.00210073956044 ko04010 MAPK signaling pathway 10/510 321/7206 0.00254374802315 ko04072 Phospholipase D signaling pathway 4/510 197/7206 0.00270204266947 ko04911 Insulin secretion 1/510 117/7206 0.00309909196681 ko04668 TNF signaling pathway 1/510 120/7206 0.00324489292767 ko04727 GABAergic synapse 1/510 110/7206 0.00451476872475 ko05032 Morphine addiction 1/510 110/7206 0.00451476872475 ko04725 Cholinergic synapse 3/510 160/7206 0.00472528390864 ko04152 AMPK signaling pathway 3/510 161/7206 0.0047279914948 ko00230 Purine metabolism 24/510 194/7206 0.00650202660711 ko04371 Apelin signaling pathway 4/510 177/7206 0.00705905499868 ko04062 Chemokine signaling pathway 5/510 201/7206 0.00733150984059 ko05169 Epstein-Barr virus infection 25/510 206/7206 0.00803043550064 ko05142 Chagas disease (American trypanosomiasis) 2/510 130/7206 0.00846575074572 ko04514 Cell adhesion molecules (CAMs) 2/510 130/7206 0.00846575074572 ko04360 Axon guidance 7/510 233/7206 0.0092384986616 ko05205 Proteoglycans in cancer 9/510 271/7206 0.0108138410527 ko04750 Inflammatory mediator regulation of TRP channels 2/510 122/7206 0.0117791432647 ko04666 Fc gamma R-mediated phagocytosis 2/510 122/7206 0.0117791432647 ko04066 HIF-1 signaling pathway 2/510 123/7206 0.0118553586292 ko05168 Herpes simplex infection 22/510 182/7206 0.0120959091373 ko05145 Toxoplasmosis 2/510 126/7206 0.0124035248443 ko04064 NF-kappa B signaling pathway 1/510 96/7206 0.0142365365765 ko04971 Gastric acid secretion 1/510 98/7206 0.0148196606216 ko04931 Insulin resistance 3/510 137/7206 0.0179145905349 ko04726 Serotonergic synapse 3/510 137/7206 0.0179145905349 ko04611 Platelet activation 4/510 163/7206 0.0188879878168 ko05031 Amphetamine addiction 1/510 91/7206 0.0208910618502 ko04972 Pancreatic secretion 2/510 111/7206 0.0236463182503 ko04070 Phosphatidylinositol signaling system 2/510 112/7206 0.0238522726304 ko04915 Estrogen signaling pathway 3/510 131/7206 0.0247930952656 ko04630 Jak-STAT signaling pathway 3/510 132/7206 0.0248487680972 ko04380 Osteoclast differentiation 3/510 134/7206 0.0252121348015 ko05034 Alcoholism 26/510 238/7206 0.0276073766516 ko01230 Biosynthesis of amino acids 1/510 85/7206 0.0300932372946 ko04924 Renin secretion 1/510 86/7206 0.0306493734809 ko04520 Adherens junction 2/510 103/7206 0.0331219313459 ko04659 Th17 cell differentiation 2/510 106/7206 0.033515289897 ko04142 Lysosome 4/510 151/7206 0.0348130496698 ko05202 Transcriptional misregulation in cancer 21/510 188/7206 0.0416350078377 ko04612 Antigen processing and presentation 1/510 77/7206 0.0424715304816 ko04145 Phagosome 5/510 162/7206 0.0431335743452 ko04512 ECM-receptor interaction 1/510 79/7206 0.0432958128428 ko04139 Mitophagy - yeast 6/510 37/7206 0.043497539142 ko04140 Autophagy - animal 5/510 164/7206 0.0435124813552 ko04721 Synaptic vesicle cycle 1/510 80/7206 0.0440106423973 ko00564 Glycerophospholipid metabolism 2/510 99/7206 0.0466203197375 ko04620 Toll-like receptor signaling pathway 2/510 100/7206 0.0469472541837 ko04912 GnRH signaling pathway 3/510 122/7206 0.0476304493117