ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	203/1294	423/7206	1.00049929961e-48
ko04724	Glutamatergic synapse	93/1294	152/7206	4.40443303825e-33
ko05033	Nicotine addiction	48/1294	56/7206	2.46106471643e-28
ko05032	Morphine addiction	70/1294	110/7206	1.26913215999e-26
ko04727	GABAergic synapse	69/1294	110/7206	1.04424500016e-25
ko04713	Circadian entrainment	76/1294	136/7206	1.14653622227e-23
ko04721	Synaptic vesicle cycle	52/1294	80/7206	1.09850501493e-20
ko04728	Dopaminergic synapse	87/1294	185/7206	3.34297119888e-20
ko04725	Cholinergic synapse	78/1294	160/7206	2.12899942942e-19
ko04024	cAMP signaling pathway	110/1294	279/7206	9.07180738442e-18
ko04020	Calcium signaling pathway	105/1294	265/7206	2.75909009737e-17
ko04723	Retrograde endocannabinoid signaling	78/1294	175/7206	1.53682187817e-16
ko04742	Taste transduction	40/1294	61/7206	2.13945353476e-16
ko04726	Serotonergic synapse	65/1294	137/7206	1.29397117059e-15
ko04911	Insulin secretion	57/1294	117/7206	1.77048493339e-14
ko04921	Oxytocin signaling pathway	83/1294	209/7206	6.48301630511e-14
ko04744	Phototransduction	27/1294	36/7206	1.02827856146e-13
ko04261	Adrenergic signaling in cardiomyocytes	77/1294	205/7206	1.52728363018e-11
ko05031	Amphetamine addiction	43/1294	91/7206	1.08107052242e-10
ko04970	Salivary secretion	44/1294	95/7206	1.4965196269e-10
ko04720	Long-term potentiation	45/1294	99/7206	2.00997868699e-10
ko03040	Spliceosome	2/1294	145/7206	2.22663268382e-10
ko03010	Ribosome	1/1294	129/7206	3.38704653681e-10
ko04740	Olfactory transduction	37/1294	80/7206	4.60149108693e-09
ko04060	Cytokine-cytokine receptor interaction	8/1294	191/7206	1.4602445665e-08
ko05203	Viral carcinogenesis	18/1294	277/7206	2.46593590283e-08
ko05168	Herpes simplex infection	8/1294	182/7206	4.38066301446e-08
ko04022	cGMP-PKG signaling pathway	71/1294	216/7206	7.27365920855e-08
ko04925	Aldosterone synthesis and secretion	41/1294	105/7206	2.70832984023e-07
ko05322	Systemic lupus erythematosus	6/1294	151/7206	2.77976249251e-07
ko03013	RNA transport	8/1294	166/7206	5.88519187688e-07
ko04971	Gastric acid secretion	38/1294	98/7206	9.21785196863e-07
ko04360	Axon guidance	72/1294	233/7206	9.29869851192e-07
ko05030	Cocaine addiction	31/1294	73/7206	1.35609744216e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1294	74/7206	4.54178098608e-06
ko04966	Collecting duct acid secretion	15/1294	26/7206	6.3747883909e-06
ko04976	Bile secretion	31/1294	80/7206	1.09929749276e-05
ko04621	NOD-like receptor signaling pathway	9/1294	157/7206	1.18261421873e-05
ko04070	Phosphatidylinositol signaling system	39/1294	112/7206	1.66360552078e-05
ko04010	MAPK signaling pathway	88/1294	321/7206	1.95254314726e-05
ko04924	Renin secretion	32/1294	86/7206	2.40622793153e-05
ko05164	Influenza A	11/1294	167/7206	2.41447933529e-05
ko04972	Pancreatic secretion	38/1294	111/7206	3.03532137083e-05
ko04540	Gap junction	42/1294	128/7206	3.86769998163e-05
ko04610	Complement and coagulation cascades	2/1294	79/7206	4.44054072934e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1294	79/7206	4.44054072934e-05
ko04110	Cell cycle	9/1294	145/7206	6.52721698604e-05
ko04514	Cell adhesion molecules (CAMs)	42/1294	130/7206	6.82977163628e-05
ko04064	NF-kappa B signaling pathway	4/1294	96/7206	7.92181952573e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1294	79/7206	8.03673871059e-05
ko05414	Dilated cardiomyopathy	37/1294	112/7206	9.73080292792e-05
ko05140	Leishmaniasis	2/1294	75/7206	0.000102680881224
ko04745	Phototransduction - fly	17/1294	38/7206	0.00012005814077
ko04120	Ubiquitin mediated proteolysis	9/1294	138/7206	0.00012315503484
ko04923	Regulation of lipolysis in adipocytes	28/1294	77/7206	0.000125351984383
ko04072	Phospholipase D signaling pathway	57/1294	197/7206	0.000143855588893
ko04730	Long-term depression	28/1294	78/7206	0.000146306612997
ko04260	Cardiac muscle contraction	33/1294	98/7206	0.000160857200375
ko04964	Proximal tubule bicarbonate reclamation	14/1294	29/7206	0.000177095524673
ko04371	Apelin signaling pathway	51/1294	177/7206	0.000321208843699
ko05110	Vibrio cholerae infection	23/1294	63/7206	0.000403933441335
ko04915	Estrogen signaling pathway	40/1294	131/7206	0.000481653186411
ko05205	Proteoglycans in cancer	28/1294	271/7206	0.00049991937268
ko00480	Glutathione metabolism	1/1294	55/7206	0.000543600375547
ko04750	Inflammatory mediator regulation of TRP channels	37/1294	122/7206	0.000762647567725
ko00590	Arachidonic acid metabolism	1/1294	52/7206	0.00078720954311
ko05161	Hepatitis B	15/1294	173/7206	0.000847004958218
ko05169	Epstein-Barr virus infection	20/1294	206/7206	0.00118628065256
ko04141	Protein processing in endoplasmic reticulum	17/1294	184/7206	0.00122464810163
ko04014	Ras signaling pathway	71/1294	279/7206	0.00140657086049
ko05162	Measles	9/1294	120/7206	0.00163468448692
ko03420	Nucleotide excision repair	1/1294	46/7206	0.00177928263025
ko04626	Plant-pathogen interaction	9/1294	18/7206	0.00193260619369
ko00240	Pyrimidine metabolism	8/1294	110/7206	0.00237135918374
ko05321	Inflammatory bowel disease (IBD)	2/1294	56/7206	0.00244527005912
ko03022	Basal transcription factors	1/1294	44/7206	0.00268585996483
ko05144	Malaria	1/1294	45/7206	0.00273694988397
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1294	59/7206	0.00316020437467
ko04146	Peroxisome	6/1294	89/7206	0.00329927051604
ko05131	Shigellosis	5/1294	82/7206	0.00334406110804
ko04622	RIG-I-like receptor signaling pathway	3/1294	62/7206	0.00416586240005
ko04657	IL-17 signaling pathway	6/1294	87/7206	0.00458817874458
ko05133	Pertussis	6/1294	87/7206	0.00458817874458
ko04922	Glucagon signaling pathway	36/1294	128/7206	0.00490752312647
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1294	14/7206	0.0062708414155
ko05166	HTLV-I infection	35/1294	292/7206	0.0062760671998
ko00562	Inositol phosphate metabolism	26/1294	89/7206	0.00798276617957
ko04710	Circadian rhythm	15/1294	43/7206	0.00799441651014
ko04115	p53 signaling pathway	5/1294	74/7206	0.00900707087794
ko05145	Toxoplasmosis	12/1294	126/7206	0.00993435602301
ko04658	Th1 and Th2 cell differentiation	8/1294	96/7206	0.0106338749307
ko04630	Jak-STAT signaling pathway	13/1294	132/7206	0.0116714816409
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1294	100/7206	0.0121553691935
ko04214	Apoptosis - fly	5/1294	72/7206	0.0126065921915
ko04350	TGF-beta signaling pathway	9/1294	103/7206	0.01330378521
ko04612	Antigen processing and presentation	6/1294	77/7206	0.016425784689
ko05206	MicroRNAs in cancer	20/1294	177/7206	0.017254322604
ko04330	Notch signaling pathway	4/1294	62/7206	0.0183964276795
ko04930	Type II diabetes mellitus	17/1294	54/7206	0.0187463476677
ko03018	RNA degradation	7/1294	84/7206	0.0210601468529
ko00860	Porphyrin and chlorophyll metabolism	1/1294	34/7206	0.0219749021215
ko04213	Longevity regulating pathway - multiple species	24/1294	86/7206	0.0226464090146
ko05016	Huntington's disease	26/1294	215/7206	0.0237204738952
ko00512	Mucin type O-glycan biosynthesis	10/1294	29/7206	0.0280965902167
ko04217	Necroptosis	21/1294	178/7206	0.0293845960483
ko05231	Choline metabolism in cancer	34/1294	134/7206	0.0302601034576
ko04640	Hematopoietic cell lineage	5/1294	64/7206	0.0326228161499
ko04620	Toll-like receptor signaling pathway	10/1294	100/7206	0.0355575288633
ko05219	Bladder cancer	3/1294	48/7206	0.0359203703937
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1294	40/7206	0.0359277084494
ko04932	Non-alcoholic fatty liver disease (NAFLD)	22/1294	182/7206	0.0394234912903
ko04933	AGE-RAGE signaling pathway in diabetic complications	15/1294	135/7206	0.0407425527628
ko04973	Carbohydrate digestion and absorption	13/1294	42/7206	0.0408604418798
ko03320	PPAR signaling pathway	6/1294	69/7206	0.0409291535928
ko04668	TNF signaling pathway	13/1294	120/7206	0.0410254178519
ko04912	GnRH signaling pathway	31/1294	122/7206	0.0420625877512
ko00330	Arginine and proline metabolism	5/1294	61/7206	0.0444569110182
ko05418	Fluid shear stress and atherosclerosis	21/1294	173/7206	0.0446592060247
ko05132	Salmonella infection	10/1294	98/7206	0.0461685997761
ko05320	Autoimmune thyroid disease	1/1294	29/7206	0.0483478971372
ko01524	Platinum drug resistance	7/1294	76/7206	0.0496844268312