ko pathway ratio_in_study ratio_in_pop p_value ko04610 Complement and coagulation cascades 27/335 79/7206 4.20783146572e-17 ko04974 Protein digestion and absorption 22/335 96/7206 2.78861952054e-10 ko04976 Bile secretion 20/335 80/7206 3.49628110692e-10 ko00350 Tyrosine metabolism 13/335 33/7206 9.28379449153e-10 ko00983 Drug metabolism - other enzymes 13/335 42/7206 2.82355011415e-08 ko00380 Tryptophan metabolism 14/335 50/7206 3.440289079e-08 ko00360 Phenylalanine metabolism 8/335 17/7206 3.3795711327e-07 ko04614 Renin-angiotensin system 8/335 18/7206 5.83850009999e-07 ko04975 Fat digestion and absorption 10/335 35/7206 2.67509064321e-06 ko02010 ABC transporters 10/335 39/7206 7.84300555963e-06 ko00140 Steroid hormone biosynthesis 10/335 41/7206 1.27268024311e-05 ko05166 HTLV-I infection 1/335 292/7206 2.30654846266e-05 ko00591 Linoleic acid metabolism 7/335 22/7206 4.103792945e-05 ko00950 Isoquinoline alkaloid biosynthesis 5/335 10/7206 4.37883857381e-05 ko00260 Glycine, serine and threonine metabolism 10/335 48/7206 5.55199868464e-05 ko03320 PPAR signaling pathway 12/335 69/7206 6.72676683368e-05 ko04978 Mineral absorption 9/335 40/7206 6.92831580649e-05 ko00340 Histidine metabolism 7/335 25/7206 0.000102498193399 ko00830 Retinol metabolism 9/335 42/7206 0.000104053046099 ko04146 Peroxisome 13/335 89/7206 0.000214473690998 ko00120 Primary bile acid biosynthesis 6/335 20/7206 0.000214847174438 ko00982 Drug metabolism - cytochrome P450 8/335 37/7206 0.00023697610325 ko05204 Chemical carcinogenesis 9/335 48/7206 0.000305874819234 ko05200 Pathways in cancer 8/335 492/7206 0.000335290648912 ko04360 Axon guidance 1/335 233/7206 0.000354652095986 ko04977 Vitamin digestion and absorption 6/335 22/7206 0.000382168685136 ko00643 Styrene degradation 3/335 4/7206 0.00038469347776 ko04972 Pancreatic secretion 14/335 111/7206 0.000586192532293 ko04973 Carbohydrate digestion and absorption 8/335 42/7206 0.000591325645798 ko00232 Caffeine metabolism 3/335 5/7206 0.000928563303399 ko00040 Pentose and glucuronate interconversions 6/335 26/7206 0.00100732788885 ko05150 Staphylococcus aureus infection 7/335 36/7206 0.00114492298094 ko04144 Endocytosis 5/335 342/7206 0.00217038360046 ko00590 Arachidonic acid metabolism 8/335 52/7206 0.00251613418538 ko00053 Ascorbate and aldarate metabolism 5/335 22/7206 0.00288318615058 ko04010 MAPK signaling pathway 5/335 321/7206 0.00403612800458 ko00640 Propanoate metabolism 6/335 34/7206 0.00430114024419 ko00860 Porphyrin and chlorophyll metabolism 6/335 34/7206 0.00430114024419 ko00410 beta-Alanine metabolism 6/335 35/7206 0.00499242836685 ko00500 Starch and sucrose metabolism 6/335 35/7206 0.00499242836685 ko04723 Retrograde endocannabinoid signaling 1/335 175/7206 0.00519480301883 ko04550 Signaling pathways regulating pluripotency of stem cells 1/335 165/7206 0.00737260162756 ko03013 RNA transport 1/335 166/7206 0.00748537891428 ko00250 Alanine, aspartate and glutamate metabolism 6/335 38/7206 0.00755512821089 ko04920 Adipocytokine signaling pathway 10/335 89/7206 0.00798640251315 ko04913 Ovarian steroidogenesis 8/335 63/7206 0.00832361138007 ko00980 Metabolism of xenobiotics by cytochrome P450 6/335 40/7206 0.00971946236055 ko00592 alpha-Linolenic acid metabolism 4/335 19/7206 0.0102089701471 ko04724 Glutamatergic synapse 1/335 152/7206 0.0102799152301 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/335 4/7206 0.0121473075443 ko00965 Betalain biosynthesis 2/335 4/7206 0.0121473075443 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/335 11/7206 0.0124335867066 ko04141 Protein processing in endoplasmic reticulum 2/335 184/7206 0.0124616074558 ko00100 Steroid biosynthesis 4/335 21/7206 0.0146532861973 ko03040 Spliceosome 1/335 145/7206 0.0150141892013 ko04110 Cell cycle 1/335 145/7206 0.0150141892013 ko00071 Fatty acid degradation 6/335 45/7206 0.0169968117448 ko00052 Galactose metabolism 5/335 33/7206 0.0171157243848 ko00620 Pyruvate metabolism 6/335 46/7206 0.0188068034943 ko04015 Rap1 signaling pathway 5/335 278/7206 0.0188843302253 ko04014 Ras signaling pathway 5/335 279/7206 0.019001548684 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/335 5/7206 0.0196264703716 ko04152 AMPK signaling pathway 14/335 161/7206 0.0213003192745 ko04120 Ubiquitin mediated proteolysis 1/335 138/7206 0.0220035238024 ko00330 Arginine and proline metabolism 7/335 61/7206 0.0222494925298 ko00770 Pantothenate and CoA biosynthesis 3/335 14/7206 0.0247381541593 ko05224 Breast cancer 2/335 174/7206 0.0259578258224 ko00561 Glycerolipid metabolism 7/335 63/7206 0.0260929914738 ko05010 Alzheimer's disease 3/335 202/7206 0.0261012915669 ko00362 Benzoate degradation 2/335 6/7206 0.0285430948504 ko00630 Glyoxylate and dicarboxylate metabolism 5/335 38/7206 0.0300015986883 ko04660 T cell receptor signaling pathway 1/335 124/7206 0.0309051967012 ko04722 Neurotrophin signaling pathway 2/335 160/7206 0.0348749316618 ko04725 Cholinergic synapse 2/335 160/7206 0.0348749316618 ko05203 Viral carcinogenesis 6/335 277/7206 0.0413910426482 ko04964 Proximal tubule bicarbonate reclamation 4/335 29/7206 0.0435303111294 ko04950 Maturity onset diabetes of the young 4/335 29/7206 0.0435303111294 ko04666 Fc gamma R-mediated phagocytosis 1/335 122/7206 0.0462372969685 ko00901 Indole alkaloid biosynthesis 1/335 1/7206 0.0464890369139 ko00401 Novobiocin biosynthesis 1/335 1/7206 0.0464890369139 ko04151 PI3K-Akt signaling pathway 10/335 390/7206 0.0467636792252 ko05016 Huntington's disease 4/335 215/7206 0.0472677756325