ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	183/1155	423/7206	2.68559600637e-43
ko04724	Glutamatergic synapse	88/1155	152/7206	1.13262327838e-32
ko05033	Nicotine addiction	46/1155	56/7206	8.5182578003e-28
ko04721	Synaptic vesicle cycle	55/1155	80/7206	3.72805019099e-26
ko04713	Circadian entrainment	73/1155	136/7206	1.86936366329e-24
ko04727	GABAergic synapse	62/1155	110/7206	1.96309099298e-22
ko05032	Morphine addiction	62/1155	110/7206	1.96309099298e-22
ko04728	Dopaminergic synapse	85/1155	185/7206	2.66886096413e-22
ko04725	Cholinergic synapse	76/1155	160/7206	3.94663941429e-21
ko04723	Retrograde endocannabinoid signaling	75/1155	175/7206	1.2159053288e-17
ko04921	Oxytocin signaling pathway	82/1155	209/7206	2.84827393363e-16
ko04024	cAMP signaling pathway	98/1155	279/7206	1.38390914079e-15
ko04742	Taste transduction	37/1155	61/7206	2.66296462609e-15
ko04744	Phototransduction	27/1155	36/7206	5.6496800245e-15
ko04726	Serotonergic synapse	60/1155	137/7206	7.2357606598e-15
ko04911	Insulin secretion	54/1155	117/7206	1.11728582664e-14
ko04020	Calcium signaling pathway	92/1155	265/7206	3.3950088507e-14
ko04720	Long-term potentiation	47/1155	99/7206	1.6497965222e-13
ko05031	Amphetamine addiction	43/1155	91/7206	2.20907977286e-12
ko04261	Adrenergic signaling in cardiomyocytes	71/1155	205/7206	4.65169251397e-11
ko03040	Spliceosome	1/1155	145/7206	3.21004719251e-10
ko04360	Axon guidance	75/1155	233/7206	4.85078131495e-10
ko04740	Olfactory transduction	35/1155	80/7206	3.36526687643e-09
ko04970	Salivary secretion	39/1155	95/7206	3.99272563063e-09
ko05168	Herpes simplex infection	5/1155	182/7206	8.4298028532e-09
ko04925	Aldosterone synthesis and secretion	39/1155	105/7206	1.14718875395e-07
ko05203	Viral carcinogenesis	16/1155	277/7206	1.66505979711e-07
ko04971	Gastric acid secretion	37/1155	98/7206	1.69565912024e-07
ko04120	Ubiquitin mediated proteolysis	3/1155	138/7206	2.12208374636e-07
ko05030	Cocaine addiction	30/1155	73/7206	2.43609676215e-07
ko04060	Cytokine-cytokine receptor interaction	8/1155	191/7206	3.68041652801e-07
ko04010	MAPK signaling pathway	86/1155	321/7206	4.87140886716e-07
ko03013	RNA transport	6/1155	166/7206	5.2994606101e-07
ko04745	Phototransduction - fly	19/1155	38/7206	1.11925260216e-06
ko04966	Collecting duct acid secretion	15/1155	26/7206	1.45139441446e-06
ko04260	Cardiac muscle contraction	35/1155	98/7206	2.03878574095e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1155	74/7206	6.59623964186e-06
ko04540	Gap junction	41/1155	128/7206	7.36911347038e-06
ko04022	cGMP-PKG signaling pathway	60/1155	216/7206	7.92505056898e-06
ko04621	NOD-like receptor signaling pathway	7/1155	157/7206	8.18221551282e-06
ko04730	Long-term depression	28/1155	78/7206	1.50969649192e-05
ko04924	Renin secretion	30/1155	86/7206	1.81739330193e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1155	79/7206	1.93353649534e-05
ko04141	Protein processing in endoplasmic reticulum	11/1155	184/7206	4.02162155321e-05
ko04514	Cell adhesion molecules (CAMs)	39/1155	130/7206	5.2699378145e-05
ko05322	Systemic lupus erythematosus	8/1155	151/7206	7.17535940015e-05
ko05110	Vibrio cholerae infection	23/1155	63/7206	7.53736089549e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1155	59/7206	9.118340913e-05
ko05164	Influenza A	10/1155	167/7206	0.000105052503627
ko04064	NF-kappa B signaling pathway	3/1155	96/7206	0.000111244787025
ko04014	Ras signaling pathway	69/1155	279/7206	0.000120151384
ko04626	Plant-pathogen interaction	10/1155	18/7206	0.000136649613711
ko04110	Cell cycle	8/1155	145/7206	0.000140679232242
ko05169	Epstein-Barr virus infection	15/1155	206/7206	0.000224757186314
ko04972	Pancreatic secretion	33/1155	111/7206	0.000226536511407
ko03008	Ribosome biogenesis in eukaryotes	2/1155	79/7206	0.000273591458404
ko04070	Phosphatidylinositol signaling system	33/1155	112/7206	0.00036102648285
ko05140	Leishmaniasis	2/1155	75/7206	0.000385559858547
ko04750	Inflammatory mediator regulation of TRP channels	35/1155	122/7206	0.000401814801495
ko04915	Estrogen signaling pathway	37/1155	131/7206	0.000405483113681
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1155	14/7206	0.000515183178746
ko05414	Dilated cardiomyopathy	32/1155	112/7206	0.000654894566615
ko04072	Phospholipase D signaling pathway	50/1155	197/7206	0.00073295171913
ko05162	Measles	7/1155	120/7206	0.00099538731153
ko04146	Peroxisome	4/1155	89/7206	0.00120680067991
ko05205	Proteoglycans in cancer	25/1155	271/7206	0.00127512294144
ko00480	Glutathione metabolism	1/1155	55/7206	0.00132731374009
ko04612	Antigen processing and presentation	3/1155	77/7206	0.00152864575171
ko04640	Hematopoietic cell lineage	2/1155	64/7206	0.00183220588062
ko00590	Arachidonic acid metabolism	1/1155	52/7206	0.00198600902901
ko04371	Apelin signaling pathway	44/1155	177/7206	0.00242822499772
ko04214	Apoptosis - fly	3/1155	72/7206	0.00319598132832
ko04976	Bile secretion	23/1155	80/7206	0.00337332500426
ko04964	Proximal tubule bicarbonate reclamation	11/1155	29/7206	0.0036123437419
ko00240	Pyrimidine metabolism	7/1155	110/7206	0.00361836188028
ko00330	Arginine and proline metabolism	2/1155	61/7206	0.00416382558055
ko05145	Toxoplasmosis	9/1155	126/7206	0.00449619190488
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1155	100/7206	0.00544494280906
ko05321	Inflammatory bowel disease (IBD)	2/1155	56/7206	0.00578432958151
ko05161	Hepatitis B	15/1155	173/7206	0.00612530740306
ko03022	Basal transcription factors	1/1155	44/7206	0.00672458168969
ko00071	Fatty acid degradation	1/1155	45/7206	0.0068170854145
ko01524	Platinum drug resistance	4/1155	76/7206	0.00694949675641
ko03420	Nucleotide excision repair	1/1155	46/7206	0.007151124291
ko04916	Melanogenesis	35/1155	142/7206	0.00747116759379
ko04912	GnRH signaling pathway	31/1155	122/7206	0.0083420989182
ko00310	Lysine degradation	4/1155	73/7206	0.00974174236301
ko03018	RNA degradation	5/1155	84/7206	0.0100303975088
ko00140	Steroid hormone biosynthesis	1/1155	41/7206	0.0101109875253
ko04630	Jak-STAT signaling pathway	11/1155	132/7206	0.0118135663026
ko04015	Rap1 signaling pathway	60/1155	278/7206	0.0122733995205
ko04930	Type II diabetes mellitus	16/1155	54/7206	0.0135494349737
ko04622	RIG-I-like receptor signaling pathway	3/1155	62/7206	0.0135717200783
ko05166	HTLV-I infection	32/1155	292/7206	0.0144515601944
ko04922	Glucagon signaling pathway	31/1155	128/7206	0.0146408270958
ko05034	Alcoholism	52/1155	238/7206	0.0152189197653
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1155	40/7206	0.0153278536065
ko04668	TNF signaling pathway	10/1155	120/7206	0.0170252226262
ko04657	IL-17 signaling pathway	6/1155	87/7206	0.0177403799137
ko00260	Glycine, serine and threonine metabolism	2/1155	48/7206	0.0178308212929
ko05214	Glioma	21/1155	79/7206	0.0192626767107
ko03320	PPAR signaling pathway	4/1155	69/7206	0.0194546331831
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1155	92/7206	0.0222103436051
ko00982	Drug metabolism - cytochrome P450	1/1155	37/7206	0.0225992344104
ko03410	Base excision repair	1/1155	38/7206	0.0234310530716
ko04115	p53 signaling pathway	5/1155	74/7206	0.0253376870911
ko04722	Neurotrophin signaling pathway	36/1155	160/7206	0.0289333176026
ko00562	Inositol phosphate metabolism	22/1155	89/7206	0.0292015426075
ko04217	Necroptosis	18/1155	178/7206	0.0293775173085
ko05231	Choline metabolism in cancer	31/1155	134/7206	0.0315025626762
ko05131	Shigellosis	6/1155	82/7206	0.0325963117864
ko00640	Propanoate metabolism	1/1155	34/7206	0.0334336348164
ko04973	Carbohydrate digestion and absorption	12/1155	42/7206	0.0340878113785
ko00500	Starch and sucrose metabolism	1/1155	35/7206	0.0342250878118
ko04658	Th1 and Th2 cell differentiation	8/1155	96/7206	0.0356925060163
ko00600	Sphingolipid metabolism	4/1155	63/7206	0.0368134541381
ko00280	Valine, leucine and isoleucine degradation	3/1155	54/7206	0.038247098104
ko05144	Malaria	2/1155	45/7206	0.0383380963363
ko05133	Pertussis	7/1155	87/7206	0.0393457516411
ko05222	Small cell lung cancer	7/1155	89/7206	0.0401912615973
ko04062	Chemokine signaling pathway	43/1155	201/7206	0.0403388743794
ko04350	TGF-beta signaling pathway	9/1155	103/7206	0.0420000344164
ko04923	Regulation of lipolysis in adipocytes	19/1155	77/7206	0.0425997985705
ko04114	Oocyte meiosis	31/1155	139/7206	0.046975290039
ko04136	Autophagy - other	1/1155	31/7206	0.0495709063231