ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 31/263 191/7206 1.2819068526e-12 ko04621 NOD-like receptor signaling pathway 28/263 157/7206 1.57425622776e-12 ko05164 Influenza A 28/263 167/7206 7.54232641868e-12 ko04380 Osteoclast differentiation 24/263 134/7206 6.15547628877e-11 ko05321 Inflammatory bowel disease (IBD) 15/263 56/7206 7.75174799622e-10 ko05162 Measles 21/263 120/7206 1.59240556437e-09 ko05168 Herpes simplex infection 26/263 182/7206 1.66898483825e-09 ko04620 Toll-like receptor signaling pathway 19/263 100/7206 2.3471502139e-09 ko04064 NF-kappa B signaling pathway 18/263 96/7206 7.8394258118e-09 ko05140 Leishmaniasis 15/263 75/7206 5.82635052919e-08 ko04622 RIG-I-like receptor signaling pathway 13/263 62/7206 2.54404029504e-07 ko04658 Th1 and Th2 cell differentiation 16/263 96/7206 3.02171115342e-07 ko04217 Necroptosis 22/263 178/7206 4.38609477569e-07 ko04672 Intestinal immune network for IgA production 10/263 37/7206 5.15227488962e-07 ko05340 Primary immunodeficiency 9/263 30/7206 7.31546451095e-07 ko05161 Hepatitis B 21/263 173/7206 1.09514763141e-06 ko04668 TNF signaling pathway 17/263 120/7206 1.39697557818e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 22/263 191/7206 1.48417547112e-06 ko04650 Natural killer cell mediated cytotoxicity 15/263 97/7206 1.92100517955e-06 ko05145 Toxoplasmosis 17/263 126/7206 2.78952044855e-06 ko05323 Rheumatoid arthritis 14/263 89/7206 3.45498537179e-06 ko05152 Tuberculosis 21/263 187/7206 3.90699598983e-06 ko04630 Jak-STAT signaling pathway 17/263 132/7206 5.32930323095e-06 ko04659 Th17 cell differentiation 15/263 106/7206 5.99180023942e-06 ko04660 T cell receptor signaling pathway 16/263 124/7206 9.88665819785e-06 ko05160 Hepatitis C 18/263 153/7206 1.02403924605e-05 ko04623 Cytosolic DNA-sensing pathway 9/263 41/7206 1.25868134479e-05 ko05330 Allograft rejection 7/263 24/7206 1.61705498306e-05 ko04612 Antigen processing and presentation 12/263 77/7206 1.92466384701e-05 ko04210 Apoptosis 19/263 180/7206 2.77646451835e-05 ko05332 Graft-versus-host disease 6/263 18/7206 2.86260042833e-05 ko05150 Staphylococcus aureus infection 8/263 36/7206 3.51965987203e-05 ko05320 Autoimmune thyroid disease 7/263 29/7206 6.23406260564e-05 ko04940 Type I diabetes mellitus 7/263 32/7206 0.000122390508363 ko04610 Complement and coagulation cascades 10/263 79/7206 0.000551327884281 ko05131 Shigellosis 10/263 82/7206 0.000743708375099 ko05142 Chagas disease (American trypanosomiasis) 13/263 130/7206 0.000873633715978 ko04670 Leukocyte transendothelial migration 14/263 151/7206 0.00118141454245 ko05133 Pertussis 10/263 87/7206 0.0011853406686 ko04662 B cell receptor signaling pathway 10/263 88/7206 0.00129525919289 ko04062 Chemokine signaling pathway 17/263 201/7206 0.00154097140728 ko04145 Phagosome 14/263 162/7206 0.00231001378917 ko05166 HTLV-I infection 21/263 292/7206 0.00340526897585 ko04657 IL-17 signaling pathway 9/263 87/7206 0.00426608859907 ko05134 Legionellosis 8/263 74/7206 0.00530062610963 ko05144 Malaria 6/263 45/7206 0.00549707023504 ko05132 Salmonella infection 9/263 98/7206 0.00925783617554 ko05034 Alcoholism 2/263 238/7206 0.0126817846896 ko05416 Viral myocarditis 6/263 55/7206 0.0144648453456 ko04728 Dopaminergic synapse 1/263 185/7206 0.0152816737641 ko05120 Epithelial cell signaling in Helicobacter pylori infection 8/263 92/7206 0.0187133685207 ko04664 Fc epsilon RI signaling pathway 7/263 77/7206 0.0217726652816 ko05310 Asthma 3/263 17/7206 0.0223669460179 ko05016 Huntington's disease 2/263 215/7206 0.0251394290365 ko04933 AGE-RAGE signaling pathway in diabetic complications 10/263 135/7206 0.031780345597 ko04550 Signaling pathways regulating pluripotency of stem cells 1/263 165/7206 0.0322242282197 ko04917 Prolactin signaling pathway 7/263 87/7206 0.039049106225 ko00590 Arachidonic acid metabolism 5/263 52/7206 0.0401539233964 ko04080 Neuroactive ligand-receptor interaction 8/263 423/7206 0.0446361886895 ko04724 Glutamatergic synapse 1/263 152/7206 0.0456679247576 ko03050 Proteasome 5/263 54/7206 0.0461090042491