ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 120/769 423/7206 9.09912360776e-26 ko04724 Glutamatergic synapse 53/769 152/7206 6.79106845932e-16 ko04713 Circadian entrainment 45/769 136/7206 9.6357536507e-13 ko04911 Insulin secretion 41/769 117/7206 1.19682347926e-12 ko04020 Calcium signaling pathway 68/769 265/7206 1.68374782128e-12 ko04725 Cholinergic synapse 49/769 160/7206 2.45934879778e-12 ko04727 GABAergic synapse 38/769 110/7206 1.34317489447e-11 ko05032 Morphine addiction 37/769 110/7206 6.14736520344e-11 ko05033 Nicotine addiction 24/769 56/7206 5.24051233358e-10 ko04728 Dopaminergic synapse 48/769 185/7206 3.02919454662e-09 ko04726 Serotonergic synapse 39/769 137/7206 4.70849079467e-09 ko04022 cGMP-PKG signaling pathway 50/769 216/7206 7.16400464101e-08 ko04970 Salivary secretion 29/769 95/7206 8.59824381091e-08 ko04723 Retrograde endocannabinoid signaling 43/769 175/7206 1.38216957349e-07 ko04971 Gastric acid secretion 29/769 98/7206 1.8226445239e-07 ko04024 cAMP signaling pathway 58/769 279/7206 4.66630748176e-07 ko04921 Oxytocin signaling pathway 46/769 209/7206 1.15873516549e-06 ko05322 Systemic lupus erythematosus 1/769 151/7206 1.43081240439e-06 ko04721 Synaptic vesicle cycle 24/769 80/7206 1.58982695447e-06 ko05031 Amphetamine addiction 26/769 91/7206 1.65455814543e-06 ko03040 Spliceosome 1/769 145/7206 2.02269868378e-06 ko05168 Herpes simplex infection 3/769 182/7206 4.05989204858e-06 ko04270 Vascular smooth muscle contraction 36/769 154/7206 4.11374470961e-06 ko04974 Protein digestion and absorption 25/769 96/7206 1.58865147151e-05 ko04261 Adrenergic signaling in cardiomyocytes 42/769 205/7206 2.6468786999e-05 ko04120 Ubiquitin mediated proteolysis 2/769 138/7206 3.83866482581e-05 ko04742 Taste transduction 18/769 61/7206 4.08866110758e-05 ko04720 Long-term potentiation 25/769 99/7206 4.10823266946e-05 ko04922 Glucagon signaling pathway 29/769 128/7206 6.69556547229e-05 ko04925 Aldosterone synthesis and secretion 25/769 105/7206 8.71611106444e-05 ko00010 Glycolysis / Gluconeogenesis 19/769 74/7206 0.000199886573828 ko05014 Amyotrophic lateral sclerosis (ALS) 19/769 74/7206 0.000199886573828 ko04514 Cell adhesion molecules (CAMs) 28/769 130/7206 0.000251678993829 ko04916 Melanogenesis 30/769 142/7206 0.000266199491887 ko03013 RNA transport 5/769 166/7206 0.000484031063034 ko04730 Long-term depression 19/769 78/7206 0.000558133060341 ko04110 Cell cycle 4/769 145/7206 0.000580670516333 ko04371 Apelin signaling pathway 34/769 177/7206 0.000734350985036 ko04141 Protein processing in endoplasmic reticulum 7/769 184/7206 0.00098201179217 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/769 59/7206 0.00102535361427 ko05164 Influenza A 6/769 167/7206 0.00133552783368 ko05162 Measles 3/769 120/7206 0.00145711705921 ko04745 Phototransduction - fly 11/769 38/7206 0.00152724110779 ko04972 Pancreatic secretion 23/769 111/7206 0.00160622646347 ko05030 Cocaine addiction 17/769 73/7206 0.00166427711077 ko04924 Renin secretion 19/769 86/7206 0.00214037243255 ko04540 Gap junction 25/769 128/7206 0.00226161542546 ko04964 Proximal tubule bicarbonate reclamation 9/769 29/7206 0.00238866743769 ko05140 Leishmaniasis 1/769 75/7206 0.00395934535868 ko00643 Styrene degradation 3/769 4/7206 0.00445802822575 ko05414 Dilated cardiomyopathy 22/769 112/7206 0.00473998250469 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 17/769 79/7206 0.0048114903122 ko04740 Olfactory transduction 17/769 80/7206 0.00519023405071 ko05203 Viral carcinogenesis 16/769 277/7206 0.00527883528853 ko04630 Jak-STAT signaling pathway 5/769 132/7206 0.00639148338902 ko04750 Inflammatory mediator regulation of TRP channels 23/769 122/7206 0.00690982858995 ko00680 Methane metabolism 9/769 34/7206 0.00769331990949 ko04260 Cardiac muscle contraction 19/769 98/7206 0.00812254266037 ko04626 Plant-pathogen interaction 6/769 18/7206 0.00871363466178 ko04960 Aldosterone-regulated sodium reabsorption 10/769 41/7206 0.00936343919044 ko04512 ECM-receptor interaction 16/769 79/7206 0.00963938467982 ko04930 Type II diabetes mellitus 12/769 54/7206 0.0122723985589 ko04919 Thyroid hormone signaling pathway 25/769 143/7206 0.012887890975 ko01200 Carbon metabolism 23/769 128/7206 0.0129360871278 ko04612 Antigen processing and presentation 2/769 77/7206 0.014929853632 ko04144 Endocytosis 23/769 342/7206 0.0150227000776 ko00710 Carbon fixation in photosynthetic organisms 7/769 27/7206 0.0202031196543 ko05169 Epstein-Barr virus infection 12/769 206/7206 0.0213589675989 ko04918 Thyroid hormone synthesis 16/769 86/7206 0.0221103379452 ko05410 Hypertrophic cardiomyopathy (HCM) 18/769 100/7206 0.0221383101247 ko04111 Cell cycle - yeast 3/769 90/7206 0.0234156808208 ko04912 GnRH signaling pathway 21/769 122/7206 0.0253993083067 ko00620 Pyruvate metabolism 10/769 46/7206 0.0264065132877 ko00280 Valine, leucine and isoleucine degradation 1/769 54/7206 0.0266038184564 ko00520 Amino sugar and nucleotide sugar metabolism 1/769 55/7206 0.0266627540679 ko04976 Bile secretion 15/769 80/7206 0.0270705913848 ko00020 Citrate cycle (TCA cycle) 8/769 35/7206 0.0280490115644 ko04978 Mineral absorption 9/769 40/7206 0.0333039085833 ko04010 MAPK signaling pathway 46/769 321/7206 0.0333693874175 ko05161 Hepatitis B 10/769 173/7206 0.0335262872363 ko05010 Alzheimer's disease 31/769 202/7206 0.0366340178892 ko04973 Carbohydrate digestion and absorption 9/769 42/7206 0.038900518759 ko00590 Arachidonic acid metabolism 1/769 52/7206 0.0393734295615 ko04011 MAPK signaling pathway - yeast 1/769 53/7206 0.0403011212676 ko04711 Circadian rhythm - fly 4/769 13/7206 0.0419570048381 ko04658 Th1 and Th2 cell differentiation 4/769 96/7206 0.0433588658103 ko05142 Chagas disease (American trypanosomiasis) 7/769 130/7206 0.0450808966674 ko04621 NOD-like receptor signaling pathway 9/769 157/7206 0.0484921532006 ko04217 Necroptosis 11/769 178/7206 0.0488994635492