ko pathway ratio_in_study ratio_in_pop p_value ko05152 Tuberculosis 33/452 187/7206 4.26381985985e-08 ko04060 Cytokine-cytokine receptor interaction 33/452 191/7206 7.24030677444e-08 ko04380 Osteoclast differentiation 26/452 134/7206 1.74526823804e-07 ko04650 Natural killer cell mediated cytotoxicity 21/452 97/7206 4.05679501226e-07 ko04610 Complement and coagulation cascades 18/452 79/7206 1.24885070894e-06 ko04137 Mitophagy - animal 18/452 82/7206 2.22640778747e-06 ko05340 Primary immunodeficiency 10/452 30/7206 8.20774188292e-06 ko05321 Inflammatory bowel disease (IBD) 13/452 56/7206 3.07472848627e-05 ko04621 NOD-like receptor signaling pathway 24/452 157/7206 3.84008486708e-05 ko05164 Influenza A 25/452 167/7206 5.56477330006e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 27/452 191/7206 5.64032754271e-05 ko04659 Th17 cell differentiation 18/452 106/7206 9.01678564212e-05 ko05162 Measles 19/452 120/7206 0.000152502803937 ko05140 Leishmaniasis 14/452 75/7206 0.00019432316341 ko03013 RNA transport 1/452 166/7206 0.000487368309842 ko05418 Fluid shear stress and atherosclerosis 23/452 173/7206 0.000619283285921 ko04145 Phagosome 22/452 162/7206 0.000755580986834 ko04658 Th1 and Th2 cell differentiation 15/452 96/7206 0.000856189782554 ko00051 Fructose and mannose metabolism 9/452 42/7206 0.000963616331329 ko04660 T cell receptor signaling pathway 18/452 124/7206 0.000973356649089 ko00120 Primary bile acid biosynthesis 6/452 20/7206 0.00107203088054 ko05145 Toxoplasmosis 18/452 126/7206 0.00107907252843 ko04620 Toll-like receptor signaling pathway 15/452 100/7206 0.00131634821149 ko05150 Staphylococcus aureus infection 8/452 36/7206 0.00143115997791 ko03040 Spliceosome 1/452 145/7206 0.00149809555543 ko04670 Leukocyte transendothelial migration 20/452 151/7206 0.00170641300258 ko04672 Intestinal immune network for IgA production 8/452 37/7206 0.0017278251213 ko04070 Phosphatidylinositol signaling system 16/452 112/7206 0.00222948729224 ko04217 Necroptosis 22/452 178/7206 0.00238424423911 ko04664 Fc epsilon RI signaling pathway 12/452 77/7206 0.00281935023816 ko04662 B cell receptor signaling pathway 13/452 88/7206 0.00311013291721 ko04666 Fc gamma R-mediated phagocytosis 16/452 122/7206 0.00414214139093 ko04710 Circadian rhythm 8/452 43/7206 0.00466348255003 ko03010 Ribosome 1/452 129/7206 0.0048752230562 ko04630 Jak-STAT signaling pathway 17/452 132/7206 0.00528688405931 ko00592 alpha-Linolenic acid metabolism 5/452 19/7206 0.00529669687472 ko04933 AGE-RAGE signaling pathway in diabetic complications 17/452 135/7206 0.00591878120058 ko04072 Phospholipase D signaling pathway 22/452 197/7206 0.00701057565338 ko04611 Platelet activation 19/452 163/7206 0.0080453668432 ko04612 Antigen processing and presentation 11/452 77/7206 0.00813209100889 ko05323 Rheumatoid arthritis 12/452 89/7206 0.0122516067758 ko05168 Herpes simplex infection 20/452 182/7206 0.0125125050886 ko04066 HIF-1 signaling pathway 15/452 123/7206 0.0127526435564 ko05034 Alcoholism 6/452 238/7206 0.0134142891686 ko04068 FoxO signaling pathway 19/452 167/7206 0.0138602995148 ko00590 Arachidonic acid metabolism 8/452 52/7206 0.0147949678061 ko00052 Galactose metabolism 6/452 33/7206 0.0153338669364 ko05230 Central carbon metabolism in cancer 11/452 81/7206 0.0168962411607 ko01040 Biosynthesis of unsaturated fatty acids 5/452 25/7206 0.0177481016064 ko05160 Hepatitis C 17/452 153/7206 0.017911514859 ko04064 NF-kappa B signaling pathway 12/452 96/7206 0.0182831314034 ko00360 Phenylalanine metabolism 4/452 17/7206 0.0189050914177 ko05144 Malaria 7/452 45/7206 0.0208043899208 ko00950 Isoquinoline alkaloid biosynthesis 3/452 10/7206 0.0211198308183 ko04015 Rap1 signaling pathway 27/452 278/7206 0.0222720117137 ko05133 Pertussis 11/452 87/7206 0.0229199629399 ko04626 Plant-pathogen interaction 4/452 18/7206 0.0231319145089 ko04146 Peroxisome 11/452 89/7206 0.0257383097201 ko00982 Drug metabolism - cytochrome P450 6/452 37/7206 0.0260810915122 ko05231 Choline metabolism in cancer 15/452 134/7206 0.0282990387432 ko04080 Neuroactive ligand-receptor interaction 16/452 423/7206 0.0293638048002 ko05214 Glioma 10/452 79/7206 0.0309015710946 ko05132 Salmonella infection 12/452 98/7206 0.0318392556762 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/452 5/7206 0.0345836275844 ko04110 Cell cycle 3/452 145/7206 0.0354817718522 ko05161 Hepatitis B 18/452 173/7206 0.0366683233246 ko04142 Lysosome 16/452 151/7206 0.0391642087144 ko04922 Glucagon signaling pathway 14/452 128/7206 0.0401111678414 ko00140 Steroid hormone biosynthesis 6/452 41/7206 0.0409304801424 ko04960 Aldosterone-regulated sodium reabsorption 6/452 41/7206 0.0409304801424 ko04136 Autophagy - other 5/452 31/7206 0.0417716893608 ko04711 Circadian rhythm - fly 3/452 13/7206 0.0437697642045 ko04972 Pancreatic secretion 2/452 111/7206 0.0472472478812