ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	205/1225	423/7206	2.5831615223e-54
ko04724	Glutamatergic synapse	87/1225	152/7206	8.29282974123e-30
ko05033	Nicotine addiction	48/1225	56/7206	1.84610656951e-29
ko05032	Morphine addiction	67/1225	110/7206	2.36405614582e-25
ko04713	Circadian entrainment	75/1225	136/7206	2.00656714048e-24
ko04727	GABAergic synapse	65/1225	110/7206	1.40011110961e-23
ko04728	Dopaminergic synapse	84/1225	185/7206	6.58378754113e-20
ko04024	cAMP signaling pathway	107/1225	279/7206	3.29812406787e-18
ko04721	Synaptic vesicle cycle	47/1225	80/7206	3.09984896873e-17
ko04020	Calcium signaling pathway	101/1225	265/7206	5.07903713273e-17
ko04725	Cholinergic synapse	72/1225	160/7206	5.93492905161e-17
ko04723	Retrograde endocannabinoid signaling	76/1225	175/7206	9.36462753456e-17
ko04742	Taste transduction	38/1225	61/7206	2.31345843075e-15
ko04744	Phototransduction	27/1225	36/7206	2.54776807582e-14
ko04911	Insulin secretion	54/1225	117/7206	1.407606014e-13
ko04726	Serotonergic synapse	59/1225	137/7206	4.41814950615e-13
ko04921	Oxytocin signaling pathway	76/1225	209/7206	7.90837017307e-12
ko03040	Spliceosome	1/1225	145/7206	7.10929870572e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1225	205/7206	7.56787352966e-11
ko04970	Salivary secretion	42/1225	95/7206	4.04744281526e-10
ko05203	Viral carcinogenesis	13/1225	277/7206	4.52435168568e-10
ko05031	Amphetamine addiction	40/1225	91/7206	1.30909198598e-09
ko04740	Olfactory transduction	36/1225	80/7206	4.05396673635e-09
ko05164	Influenza A	5/1225	167/7206	1.57816425163e-08
ko04360	Axon guidance	74/1225	233/7206	2.15492648369e-08
ko04720	Long-term potentiation	40/1225	99/7206	3.32490777593e-08
ko04971	Gastric acid secretion	38/1225	98/7206	2.10213656115e-07
ko05168	Herpes simplex infection	8/1225	182/7206	2.24210013713e-07
ko05030	Cocaine addiction	31/1225	73/7206	2.4709546609e-07
ko05322	Systemic lupus erythematosus	5/1225	151/7206	2.49806325365e-07
ko04060	Cytokine-cytokine receptor interaction	9/1225	191/7206	2.59935179111e-07
ko03013	RNA transport	7/1225	166/7206	5.69599636472e-07
ko04925	Aldosterone synthesis and secretion	39/1225	105/7206	5.80362992069e-07
ko04022	cGMP-PKG signaling pathway	66/1225	216/7206	7.36052595794e-07
ko04621	NOD-like receptor signaling pathway	7/1225	157/7206	2.5222286757e-06
ko04514	Cell adhesion molecules (CAMs)	44/1225	130/7206	2.54600053717e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1225	74/7206	1.47687728686e-05
ko05169	Epstein-Barr virus infection	14/1225	206/7206	1.89655356805e-05
ko05205	Proteoglycans in cancer	22/1225	271/7206	2.30705546475e-05
ko04972	Pancreatic secretion	37/1225	111/7206	3.04937092516e-05
ko04120	Ubiquitin mediated proteolysis	7/1225	138/7206	3.06948187384e-05
ko04141	Protein processing in endoplasmic reticulum	12/1225	184/7206	3.71215535473e-05
ko05161	Hepatitis B	11/1225	173/7206	5.19275064944e-05
ko04924	Renin secretion	30/1225	86/7206	6.05550672942e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1225	79/7206	6.20282017095e-05
ko04070	Phosphatidylinositol signaling system	36/1225	112/7206	6.80853998128e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1225	79/7206	0.000111156902781
ko04010	MAPK signaling pathway	81/1225	321/7206	0.000132656657097
ko05140	Leishmaniasis	2/1225	75/7206	0.00016196466991
ko04612	Antigen processing and presentation	2/1225	77/7206	0.000169998282972
ko04064	NF-kappa B signaling pathway	4/1225	96/7206	0.000182411373791
ko04745	Phototransduction - fly	16/1225	38/7206	0.000231347331612
ko04260	Cardiac muscle contraction	31/1225	98/7206	0.000341985049985
ko05162	Measles	7/1225	120/7206	0.000499460894322
ko05414	Dilated cardiomyopathy	34/1225	112/7206	0.000505518256036
ko04966	Collecting duct acid secretion	12/1225	26/7206	0.00051274653177
ko04540	Gap junction	37/1225	128/7206	0.000765557755447
ko04976	Bile secretion	26/1225	80/7206	0.000766511059774
ko04730	Long-term depression	25/1225	78/7206	0.0011625273753
ko05215	Prostate cancer	7/1225	111/7206	0.00130204399745
ko00240	Pyrimidine metabolism	7/1225	110/7206	0.00130342744568
ko04750	Inflammatory mediator regulation of TRP channels	35/1225	122/7206	0.0013753854352
ko04110	Cell cycle	11/1225	145/7206	0.00159044431616
ko04964	Proximal tubule bicarbonate reclamation	12/1225	29/7206	0.00167474129809
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1225	182/7206	0.00184452263142
ko04923	Regulation of lipolysis in adipocytes	24/1225	77/7206	0.00197815181583
ko04630	Jak-STAT signaling pathway	10/1225	132/7206	0.00221187205717
ko04610	Complement and coagulation cascades	4/1225	79/7206	0.00232106348869
ko05166	HTLV-I infection	31/1225	292/7206	0.00241762618015
ko04146	Peroxisome	5/1225	89/7206	0.00249839876955
ko03420	Nucleotide excision repair	1/1225	46/7206	0.00284833802519
ko04657	IL-17 signaling pathway	5/1225	87/7206	0.00357417917085
ko04658	Th1 and Th2 cell differentiation	6/1225	96/7206	0.00361028242441
ko03022	Basal transcription factors	1/1225	44/7206	0.00427038825767
ko04014	Ras signaling pathway	66/1225	279/7206	0.00427967125415
ko04371	Apelin signaling pathway	45/1225	177/7206	0.00430574234846
ko05144	Malaria	1/1225	45/7206	0.00434417527943
ko00071	Fatty acid degradation	1/1225	45/7206	0.00434417527943
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1225	14/7206	0.00456850818037
ko04620	Toll-like receptor signaling pathway	7/1225	100/7206	0.00468835520974
ko04072	Phospholipase D signaling pathway	49/1225	197/7206	0.00502894772367
ko05145	Toxoplasmosis	10/1225	126/7206	0.00548977035442
ko00480	Glutathione metabolism	2/1225	55/7206	0.00577832526523
ko04140	Autophagy - animal	15/1225	164/7206	0.0059310264821
ko04217	Necroptosis	17/1225	178/7206	0.00612691995091
ko04622	RIG-I-like receptor signaling pathway	3/1225	62/7206	0.00626391694121
ko04640	Hematopoietic cell lineage	3/1225	64/7206	0.00650926558085
ko04214	Apoptosis - fly	4/1225	72/7206	0.00667837664343
ko00310	Lysine degradation	4/1225	73/7206	0.00688272875823
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1225	59/7206	0.00872089565482
ko04210	Apoptosis	18/1225	180/7206	0.00894197365381
ko00330	Arginine and proline metabolism	3/1225	61/7206	0.00914794895202
ko05133	Pertussis	6/1225	87/7206	0.00915074075261
ko05110	Vibrio cholerae infection	19/1225	63/7206	0.01022362354
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1225	100/7206	0.0105025572111
ko05219	Bladder cancer	2/1225	48/7206	0.0117919538913
ko03018	RNA degradation	6/1225	84/7206	0.0124860743533
ko04510	Focal adhesion	27/1225	240/7206	0.0142687478264
ko00630	Glyoxylate and dicarboxylate metabolism	1/1225	38/7206	0.0149263140066
ko03410	Base excision repair	1/1225	38/7206	0.0149263140066
ko00290	Valine, leucine and isoleucine biosynthesis	3/1225	4/7206	0.017115812211
ko05131	Shigellosis	6/1225	82/7206	0.0171168231593
ko04978	Mineral absorption	13/1225	40/7206	0.017457554678
ko05418	Fluid shear stress and atherosclerosis	18/1225	173/7206	0.0181352663266
ko04115	p53 signaling pathway	5/1225	74/7206	0.0183009012092
ko05321	Inflammatory bowel disease (IBD)	3/1225	56/7206	0.0186049481633
ko04668	TNF signaling pathway	11/1225	120/7206	0.0194404874151
ko04142	Lysosome	15/1225	151/7206	0.020804501831
ko05222	Small cell lung cancer	7/1225	89/7206	0.0219061647149
ko04626	Plant-pathogen interaction	7/1225	18/7206	0.0227122118976
ko04218	Cellular senescence	19/1225	177/7206	0.0252987996206
ko04915	Estrogen signaling pathway	32/1225	131/7206	0.0258032187871
ko04330	Notch signaling pathway	4/1225	62/7206	0.0258254470023
ko00590	Arachidonic acid metabolism	3/1225	52/7206	0.0258792526076
ko00280	Valine, leucine and isoleucine degradation	3/1225	54/7206	0.0268450447885
ko04974	Protein digestion and absorption	25/1225	96/7206	0.0273414811595
ko05220	Chronic myeloid leukemia	7/1225	85/7206	0.0287556622776
ko01524	Platinum drug resistance	6/1225	76/7206	0.0312244484609
ko05146	Amoebiasis	9/1225	99/7206	0.0313385756339
ko00562	Inositol phosphate metabolism	23/1225	89/7206	0.0323568697933
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1225	135/7206	0.0372151122709
ko04137	Mitophagy - animal	7/1225	82/7206	0.0382843646619
ko05206	MicroRNAs in cancer	20/1225	177/7206	0.0423337541329
ko04930	Type II diabetes mellitus	15/1225	54/7206	0.0439501937466
ko04380	Osteoclast differentiation	14/1225	134/7206	0.047454037265
ko05320	Autoimmune thyroid disease	1/1225	29/7206	0.0483656276912