ko pathway ratio_in_study ratio_in_pop p_value ko04974 Protein digestion and absorption 17/223 96/7206 4.24492930895e-09 ko00350 Tyrosine metabolism 10/223 33/7206 3.26741958099e-08 ko04512 ECM-receptor interaction 13/223 79/7206 7.28081956155e-07 ko00643 Styrene degradation 4/223 4/7206 8.93423620292e-07 ko04260 Cardiac muscle contraction 14/223 98/7206 1.59917551665e-06 ko00360 Phenylalanine metabolism 6/223 17/7206 7.63725749353e-06 ko04510 Focal adhesion 20/223 240/7206 4.84412268631e-05 ko04261 Adrenergic signaling in cardiomyocytes 18/223 205/7206 5.93076734074e-05 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/223 4/7206 0.000114325735267 ko01200 Carbon metabolism 13/223 128/7206 0.000152683377961 ko05410 Hypertrophic cardiomyopathy (HCM) 11/223 100/7206 0.000244554552644 ko00620 Pyruvate metabolism 7/223 46/7206 0.000473235400674 ko00362 Benzoate degradation 3/223 6/7206 0.000545795770368 ko00500 Starch and sucrose metabolism 6/223 35/7206 0.000628039987427 ko04020 Calcium signaling pathway 19/223 265/7206 0.00073391377 ko00250 Alanine, aspartate and glutamate metabolism 6/223 38/7206 0.000988637283241 ko00140 Steroid hormone biosynthesis 6/223 41/7206 0.00149050885307 ko04614 Renin-angiotensin system 4/223 18/7206 0.001940778868 ko05414 Dilated cardiomyopathy 10/223 112/7206 0.00236111889026 ko00071 Fatty acid degradation 6/223 45/7206 0.00243623727071 ko00120 Primary bile acid biosynthesis 4/223 20/7206 0.0029272550382 ko00950 Isoquinoline alkaloid biosynthesis 3/223 10/7206 0.00298671721117 ko00640 Propanoate metabolism 5/223 34/7206 0.00362822888182 ko04022 cGMP-PKG signaling pathway 15/223 216/7206 0.00378738698323 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/223 11/7206 0.00401363687736 ko00380 Tryptophan metabolism 6/223 50/7206 0.00418125209622 ko01230 Biosynthesis of amino acids 8/223 85/7206 0.00460280907893 ko00010 Glycolysis / Gluconeogenesis 7/223 74/7206 0.00766544719149 ko04270 Vascular smooth muscle contraction 11/223 154/7206 0.00807660185414 ko00710 Carbon fixation in photosynthetic organisms 4/223 27/7206 0.00895338090923 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/223 5/7206 0.00896345799499 ko00281 Geraniol degradation 2/223 5/7206 0.00896345799499 ko04971 Gastric acid secretion 8/223 98/7206 0.010701096222 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 7/223 79/7206 0.0108488506559 ko00330 Arginine and proline metabolism 6/223 61/7206 0.0110354533085 ko04976 Bile secretion 7/223 80/7206 0.0115858864274 ko04371 Apelin signaling pathway 12/223 177/7206 0.0122157379728 ko00561 Glycerolipid metabolism 6/223 63/7206 0.0128349195839 ko00260 Glycine, serine and threonine metabolism 5/223 48/7206 0.0157535511262 ko00052 Galactose metabolism 4/223 33/7206 0.0180771643846 ko00230 Purine metabolism 12/223 194/7206 0.0190758030849 ko03320 PPAR signaling pathway 6/223 69/7206 0.0194511477709 ko00680 Methane metabolism 4/223 34/7206 0.0200036891181 ko00410 beta-Alanine metabolism 4/223 35/7206 0.0220521315378 ko04975 Fat digestion and absorption 4/223 35/7206 0.0220521315378 ko01210 2-Oxocarboxylic acid metabolism 3/223 20/7206 0.0225961942548 ko00280 Valine, leucine and isoleucine degradation 5/223 54/7206 0.0250877933429 ko00100 Steroid biosynthesis 3/223 21/7206 0.0257739897497 ko00630 Glyoxylate and dicarboxylate metabolism 4/223 38/7206 0.0289448072825 ko00401 Novobiocin biosynthesis 1/223 1/7206 0.0309464335277 ko02010 ABC transporters 4/223 39/7206 0.0314956134599 ko05146 Amoebiasis 7/223 99/7206 0.0333196161905 ko04152 AMPK signaling pathway 10/223 161/7206 0.0334075925331 ko04144 Endocytosis 4/223 342/7206 0.0355421342948 ko00220 Arginine biosynthesis 3/223 24/7206 0.0366638036509 ko01212 Fatty acid metabolism 5/223 60/7206 0.037386842722 ko05230 Central carbon metabolism in cancer 6/223 81/7206 0.0389264939683 ko04973 Carbohydrate digestion and absorption 4/223 42/7206 0.0399188827201 ko00650 Butanoate metabolism 3/223 26/7206 0.0450347599858 ko05203 Viral carcinogenesis 3/223 277/7206 0.0494951399076 ko04014 Ras signaling pathway 3/223 279/7206 0.049816150469