ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 45/350 152/7206 4.20456544302e-24 ko04080 Neuroactive ligand-receptor interaction 73/350 423/7206 7.5518735325e-23 ko05033 Nicotine addiction 23/350 56/7206 2.19699265942e-16 ko04713 Circadian entrainment 30/350 136/7206 1.26613139785e-12 ko04727 GABAergic synapse 26/350 110/7206 7.97239083406e-12 ko04723 Retrograde endocannabinoid signaling 33/350 175/7206 9.24542743156e-12 ko04728 Dopaminergic synapse 34/350 185/7206 9.35138315388e-12 ko04721 Synaptic vesicle cycle 21/350 80/7206 1.04437715709e-10 ko04911 Insulin secretion 25/350 117/7206 2.1231922345e-10 ko05032 Morphine addiction 23/350 110/7206 1.80647359128e-09 ko04730 Long-term depression 18/350 78/7206 2.15139390701e-08 ko04726 Serotonergic synapse 24/350 137/7206 3.20184596336e-08 ko05031 Amphetamine addiction 19/350 91/7206 4.95582371948e-08 ko04024 cAMP signaling pathway 36/350 279/7206 5.42030540738e-08 ko05014 Amyotrophic lateral sclerosis (ALS) 17/350 74/7206 5.74411008336e-08 ko04742 Taste transduction 15/350 61/7206 1.34097404986e-07 ko04020 Calcium signaling pathway 34/350 265/7206 1.49734270057e-07 ko04720 Long-term potentiation 19/350 99/7206 2.04657192627e-07 ko04514 Cell adhesion molecules (CAMs) 22/350 130/7206 2.29658988539e-07 ko04970 Salivary secretion 17/350 95/7206 2.51508340393e-06 ko04921 Oxytocin signaling pathway 27/350 209/7206 2.65978799349e-06 ko04725 Cholinergic synapse 22/350 160/7206 8.36947063152e-06 ko04261 Adrenergic signaling in cardiomyocytes 25/350 205/7206 1.75066917119e-05 ko04010 MAPK signaling pathway 33/350 321/7206 4.39793041889e-05 ko04972 Pancreatic secretion 16/350 111/7206 8.13178592948e-05 ko05030 Cocaine addiction 12/350 73/7206 0.00017944646605 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/350 59/7206 0.000479350940784 ko04260 Cardiac muscle contraction 13/350 98/7206 0.000847943491244 ko04360 Axon guidance 23/350 233/7206 0.00099271504923 ko04930 Type II diabetes mellitus 9/350 54/7206 0.00103693108229 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 11/350 79/7206 0.00140391483408 ko04964 Proximal tubule bicarbonate reclamation 6/350 29/7206 0.00230853202463 ko04971 Gastric acid secretion 12/350 98/7206 0.00266368132409 ko04022 cGMP-PKG signaling pathway 20/350 216/7206 0.00540973784027 ko04924 Renin secretion 10/350 86/7206 0.00847075278966 ko04060 Cytokine-cytokine receptor interaction 2/350 191/7206 0.00913923962591 ko04072 Phospholipase D signaling pathway 18/350 197/7206 0.0102017265746 ko03040 Spliceosome 1/350 145/7206 0.0102170717936 ko04540 Gap junction 13/350 128/7206 0.0106378976455 ko05322 Systemic lupus erythematosus 1/350 151/7206 0.0108568744995 ko05168 Herpes simplex infection 2/350 182/7206 0.0128332756197 ko04960 Aldosterone-regulated sodium reabsorption 6/350 41/7206 0.0134016927492 ko04014 Ras signaling pathway 23/350 279/7206 0.014508069313 ko04120 Ubiquitin mediated proteolysis 1/350 138/7206 0.0148711007448 ko05164 Influenza A 2/350 167/7206 0.0175369493928 ko03013 RNA transport 2/350 166/7206 0.0256996311724 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/350 14/7206 0.0277375739627 ko05010 Alzheimer's disease 17/350 202/7206 0.0284848034441 ko05162 Measles 1/350 120/7206 0.0308157294555 ko00515 Mannose type O-glycan biosynthesis 4/350 25/7206 0.0308351561207 ko05203 Viral carcinogenesis 6/350 277/7206 0.0314669727014 ko02024 Quorum sensing 3/350 15/7206 0.0334536666665 ko04745 Phototransduction - fly 5/350 38/7206 0.035320027069 ko04925 Aldosterone synthesis and secretion 10/350 105/7206 0.035969386761 ko04978 Mineral absorption 5/350 40/7206 0.0428276417733 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/350 1/7206 0.0485706355815