ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	162/855	423/7206	5.12839474491e-48
ko04724	Glutamatergic synapse	74/855	152/7206	7.92582774222e-30
ko05033	Nicotine addiction	43/855	56/7206	2.48306731019e-29
ko05032	Morphine addiction	52/855	110/7206	1.70215026984e-20
ko04727	GABAergic synapse	51/855	110/7206	1.18145651237e-19
ko04713	Circadian entrainment	57/855	136/7206	3.17890677845e-19
ko04723	Retrograde endocannabinoid signaling	62/855	175/7206	1.68988075071e-16
ko04725	Cholinergic synapse	58/855	160/7206	4.99486919919e-16
ko04728	Dopaminergic synapse	63/855	185/7206	8.70056359972e-16
ko04020	Calcium signaling pathway	78/855	265/7206	4.80330710988e-15
ko04726	Serotonergic synapse	49/855	137/7206	1.83429035437e-13
ko04024	cAMP signaling pathway	77/855	279/7206	2.34168999952e-13
ko04921	Oxytocin signaling pathway	63/855	209/7206	5.36863765706e-13
ko04911	Insulin secretion	43/855	117/7206	1.98324422996e-12
ko04742	Taste transduction	29/855	61/7206	4.67713808475e-12
ko04744	Phototransduction	19/855	36/7206	2.54245720484e-09
ko04721	Synaptic vesicle cycle	30/855	80/7206	2.62198676396e-09
ko04970	Salivary secretion	33/855	95/7206	4.10138544687e-09
ko05031	Amphetamine addiction	31/855	91/7206	2.06415656835e-08
ko05030	Cocaine addiction	26/855	73/7206	1.03258361778e-07
ko04261	Adrenergic signaling in cardiomyocytes	51/855	205/7206	1.42066602202e-07
ko04720	Long-term potentiation	31/855	99/7206	1.86379917817e-07
ko05164	Influenza A	2/855	167/7206	3.16667586041e-07
ko05203	Viral carcinogenesis	9/855	277/7206	3.42222626911e-07
ko03040	Spliceosome	1/855	145/7206	3.5003627842e-07
ko04971	Gastric acid secretion	30/855	98/7206	5.09054471737e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	25/855	74/7206	5.80795115064e-07
ko04925	Aldosterone synthesis and secretion	31/855	105/7206	7.99198687145e-07
ko04972	Pancreatic secretion	31/855	111/7206	3.70026240226e-06
ko04740	Olfactory transduction	24/855	80/7206	1.03094878011e-05
ko04022	cGMP-PKG signaling pathway	48/855	216/7206	1.39017245391e-05
ko05322	Systemic lupus erythematosus	3/855	151/7206	1.71497468516e-05
ko04730	Long-term depression	23/855	78/7206	2.1460486802e-05
ko04010	MAPK signaling pathway	63/855	321/7206	4.15077617206e-05
ko04514	Cell adhesion molecules (CAMs)	32/855	130/7206	4.6878224624e-05
ko04060	Cytokine-cytokine receptor interaction	7/855	191/7206	9.42289226617e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	22/855	79/7206	0.000128170344175
ko04110	Cell cycle	4/855	145/7206	0.000131379905088
ko04141	Protein processing in endoplasmic reticulum	7/855	184/7206	0.000183251365944
ko04260	Cardiac muscle contraction	25/855	98/7206	0.000191606513051
ko03013	RNA transport	6/855	166/7206	0.000238466062427
ko05168	Herpes simplex infection	7/855	182/7206	0.000262296440062
ko04932	Non-alcoholic fatty liver disease (NAFLD)	7/855	182/7206	0.000262296440062
ko05169	Epstein-Barr virus infection	9/855	206/7206	0.000267424959798
ko04120	Ubiquitin mediated proteolysis	4/855	138/7206	0.00026817714084
ko05162	Measles	3/855	120/7206	0.000316624463034
ko04924	Renin secretion	22/855	86/7206	0.000341712596991
ko05161	Hepatitis B	7/855	173/7206	0.000486661463958
ko04072	Phospholipase D signaling pathway	40/855	197/7206	0.000495799930847
ko05166	HTLV-I infection	17/855	292/7206	0.000583168350772
ko04360	Axon guidance	45/855	233/7206	0.000882087204143
ko05215	Prostate cancer	3/855	111/7206	0.000946255508699
ko03008	Ribosome biogenesis in eukaryotes	1/855	79/7206	0.00120515042306
ko04540	Gap junction	28/855	128/7206	0.001260561228
ko04976	Bile secretion	20/855	80/7206	0.0012784025054
ko04630	Jak-STAT signaling pathway	5/855	132/7206	0.00165163747103
ko04350	TGF-beta signaling pathway	3/855	103/7206	0.00192346421673
ko05200	Pathways in cancer	38/855	492/7206	0.00237935253396
ko04750	Inflammatory mediator regulation of TRP channels	26/855	122/7206	0.0026504652569
ko05205	Proteoglycans in cancer	17/855	271/7206	0.00281823853728
ko04218	Cellular senescence	9/855	177/7206	0.00302175913909
ko04550	Signaling pathways regulating pluripotency of stem cells	8/855	165/7206	0.00316903971897
ko04745	Phototransduction - fly	11/855	38/7206	0.00358229631772
ko05414	Dilated cardiomyopathy	24/855	112/7206	0.004485062943
ko04070	Phosphatidylinositol signaling system	24/855	112/7206	0.004485062943
ko04964	Proximal tubule bicarbonate reclamation	9/855	29/7206	0.00493720172572
ko04621	NOD-like receptor signaling pathway	8/855	157/7206	0.00567636095046
ko04612	Antigen processing and presentation	2/855	77/7206	0.00699084760617
ko05410	Hypertrophic cardiomyopathy (HCM)	21/855	100/7206	0.00760575471519
ko00190	Oxidative phosphorylation	6/855	127/7206	0.00822482733487
ko04330	Notch signaling pathway	1/855	62/7206	0.00857137938156
ko04140	Autophagy - animal	9/855	164/7206	0.00966701795413
ko04214	Apoptosis - fly	2/855	72/7206	0.00999018749146
ko05140	Leishmaniasis	2/855	75/7206	0.0104336242647
ko04150	mTOR signaling pathway	11/855	184/7206	0.0105770043087
ko05220	Chronic myeloid leukemia	3/855	85/7206	0.011035487783
ko05133	Pertussis	3/855	87/7206	0.0112066871798
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/855	59/7206	0.0128842496758
ko05202	Transcriptional misregulation in cancer	12/855	188/7206	0.0160222252768
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/855	14/7206	0.0185780508366
ko04142	Lysosome	9/855	151/7206	0.0213973387206
ko04610	Complement and coagulation cascades	3/855	79/7206	0.0217842456815
ko04978	Mineral absorption	10/855	40/7206	0.0222836824766
ko05224	Breast cancer	11/855	174/7206	0.0232291297935
ko04210	Apoptosis	12/855	180/7206	0.0263005701413
ko04973	Carbohydrate digestion and absorption	10/855	42/7206	0.027212189272
ko04620	Toll-like receptor signaling pathway	5/855	100/7206	0.0287351961752
ko04068	FoxO signaling pathway	11/855	167/7206	0.0292898851419
ko04657	IL-17 signaling pathway	4/855	87/7206	0.0299285944007
ko04146	Peroxisome	4/855	89/7206	0.0303196270479
ko04710	Circadian rhythm	10/855	43/7206	0.0304066043886
ko04930	Type II diabetes mellitus	12/855	54/7206	0.0309206340096
ko05130	Pathogenic Escherichia coli infection	3/855	77/7206	0.0311577958249
ko05144	Malaria	1/855	45/7206	0.0376670355026
ko00071	Fatty acid degradation	1/855	45/7206	0.0376670355026
ko00620	Pyruvate metabolism	1/855	46/7206	0.0377193378743
ko03420	Nucleotide excision repair	1/855	46/7206	0.0377193378743
ko00270	Cysteine and methionine metabolism	1/855	47/7206	0.0383289822908
ko05211	Renal cell carcinoma	5/855	96/7206	0.0387226835128
ko04658	Th1 and Th2 cell differentiation	5/855	96/7206	0.0387226835128
ko00260	Glycine, serine and threonine metabolism	1/855	48/7206	0.0394943997269
ko03018	RNA degradation	4/855	84/7206	0.0408976943295
ko05212	Pancreatic cancer	4/855	83/7206	0.0409241228473
ko05218	Melanoma	4/855	85/7206	0.0411960265306
ko05016	Huntington's disease	16/855	215/7206	0.0415561307242
ko01212	Fatty acid metabolism	2/855	60/7206	0.0422040054279
ko05418	Fluid shear stress and atherosclerosis	12/855	173/7206	0.0425376127724
ko02010	ABC transporters	9/855	39/7206	0.0426850268947
ko00310	Lysine degradation	3/855	73/7206	0.0428798370333
ko00330	Arginine and proline metabolism	2/855	61/7206	0.0432411671497
ko00562	Inositol phosphate metabolism	17/855	89/7206	0.0456271804613
ko04014	Ras signaling pathway	44/855	279/7206	0.0468163429361
ko04145	Phagosome	11/855	162/7206	0.0481202368465