ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 37/253 191/7206 4.44207093268e-18 ko05340 Primary immunodeficiency 15/253 30/7206 9.75579510633e-15 ko04650 Natural killer cell mediated cytotoxicity 21/253 97/7206 1.14706709151e-11 ko05168 Herpes simplex infection 28/253 182/7206 2.49645625912e-11 ko04380 Osteoclast differentiation 24/253 134/7206 2.70392268192e-11 ko05140 Leishmaniasis 18/253 75/7206 5.73905261101e-11 ko05164 Influenza A 26/253 167/7206 1.02654381161e-10 ko05162 Measles 22/253 120/7206 1.17841608903e-10 ko04621 NOD-like receptor signaling pathway 25/253 157/7206 1.45971773729e-10 ko05152 Tuberculosis 27/253 187/7206 2.57924705674e-10 ko04659 Th17 cell differentiation 20/253 106/7206 5.00878858129e-10 ko04612 Antigen processing and presentation 17/253 77/7206 8.14908446626e-10 ko05145 Toxoplasmosis 21/253 126/7206 1.97997458158e-09 ko05330 Allograft rejection 10/253 24/7206 3.0330451093e-09 ko04217 Necroptosis 24/253 178/7206 1.09254004299e-08 ko05320 Autoimmune thyroid disease 10/253 29/7206 2.6514364165e-08 ko04064 NF-kappa B signaling pathway 17/253 96/7206 2.84355727596e-08 ko05321 Inflammatory bowel disease (IBD) 13/253 56/7206 4.44989830414e-08 ko05332 Graft-versus-host disease 8/253 18/7206 6.67342596445e-08 ko04620 Toll-like receptor signaling pathway 16/253 100/7206 3.18173816321e-07 ko04062 Chemokine signaling pathway 23/253 201/7206 4.79593384382e-07 ko04630 Jak-STAT signaling pathway 18/253 132/7206 6.82811518726e-07 ko04658 Th1 and Th2 cell differentiation 15/253 96/7206 1.0284774436e-06 ko05150 Staphylococcus aureus infection 9/253 36/7206 2.88352064508e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/253 191/7206 2.96192786645e-06 ko04145 Phagosome 19/253 162/7206 3.42382579278e-06 ko04672 Intestinal immune network for IgA production 9/253 37/7206 3.69477635755e-06 ko04660 T cell receptor signaling pathway 16/253 124/7206 6.03129421563e-06 ko04622 RIG-I-like receptor signaling pathway 11/253 62/7206 8.35034228308e-06 ko04940 Type I diabetes mellitus 8/253 32/7206 1.04551224212e-05 ko04640 Hematopoietic cell lineage 11/253 64/7206 1.14794197516e-05 ko03050 Proteasome 10/253 54/7206 1.45854206413e-05 ko05144 Malaria 9/253 45/7206 2.05759890461e-05 ko05133 Pertussis 12/253 87/7206 4.60267716188e-05 ko05161 Hepatitis B 17/253 173/7206 0.000111939041772 ko05310 Asthma 5/253 17/7206 0.000224330566765 ko04662 B cell receptor signaling pathway 11/253 88/7206 0.000234547951007 ko04623 Cytosolic DNA-sensing pathway 7/253 41/7206 0.000489187632904 ko05160 Hepatitis C 14/253 153/7206 0.00092328895134 ko05323 Rheumatoid arthritis 10/253 89/7206 0.00105359910287 ko04666 Fc gamma R-mediated phagocytosis 12/253 122/7206 0.00113439927525 ko04610 Complement and coagulation cascades 9/253 79/7206 0.00168905898718 ko05142 Chagas disease (American trypanosomiasis) 12/253 130/7206 0.00196585307274 ko05416 Viral myocarditis 7/253 55/7206 0.00290846797105 ko04360 Axon guidance 1/253 233/7206 0.00339895892404 ko04664 Fc epsilon RI signaling pathway 8/253 77/7206 0.00535967621053 ko04514 Cell adhesion molecules (CAMs) 11/253 130/7206 0.0058339535851 ko05169 Epstein-Barr virus infection 15/253 206/7206 0.00635932870329 ko05016 Huntington's disease 1/253 215/7206 0.00728723224092 ko04611 Platelet activation 13/253 163/7206 0.00745139712373 ko05010 Alzheimer's disease 1/253 202/7206 0.0104867286704 ko05132 Salmonella infection 8/253 98/7206 0.0214274601906 ko05206 MicroRNAs in cancer 1/253 177/7206 0.0218096827925 ko04310 Wnt signaling pathway 1/253 181/7206 0.02210722379 ko05146 Amoebiasis 8/253 99/7206 0.0226300759051 ko05131 Shigellosis 7/253 82/7206 0.0245814291916 ko05143 African trypanosomiasis 4/253 32/7206 0.0246479922593 ko04910 Insulin signaling pathway 1/253 172/7206 0.0323930952561 ko05224 Breast cancer 1/253 174/7206 0.0330078120891 ko05166 HTLV-I infection 17/253 292/7206 0.0345566858557 ko04210 Apoptosis 12/253 180/7206 0.0357425010279 ko04142 Lysosome 10/253 151/7206 0.0437175717464 ko04670 Leukocyte transendothelial migration 10/253 151/7206 0.0437175717464 ko05012 Parkinson's disease 1/253 155/7206 0.0452169177076 ko04144 Endocytosis 19/253 342/7206 0.0481291558853