ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 52/482 191/7206 2.73698733773e-19 ko04380 Osteoclast differentiation 41/482 134/7206 2.11919944517e-17 ko04064 NF-kappa B signaling pathway 29/482 96/7206 1.73417394978e-12 ko04621 NOD-like receptor signaling pathway 37/482 157/7206 6.33439269012e-12 ko05164 Influenza A 38/482 167/7206 1.02229048851e-11 ko05340 Primary immunodeficiency 15/482 30/7206 1.18276288619e-10 ko05321 Inflammatory bowel disease (IBD) 20/482 56/7206 1.78968018541e-10 ko05140 Leishmaniasis 23/482 75/7206 2.5989587909e-10 ko04658 Th1 and Th2 cell differentiation 26/482 96/7206 3.73404769843e-10 ko05145 Toxoplasmosis 30/482 126/7206 5.155707351e-10 ko04659 Th17 cell differentiation 27/482 106/7206 7.70956489838e-10 ko04620 Toll-like receptor signaling pathway 26/482 100/7206 9.88146112449e-10 ko05168 Herpes simplex infection 36/482 182/7206 2.32665570076e-09 ko04217 Necroptosis 35/482 178/7206 4.61815096201e-09 ko05162 Measles 27/482 120/7206 1.43558415725e-08 ko04672 Intestinal immune network for IgA production 14/482 37/7206 4.3538347095e-08 ko04650 Natural killer cell mediated cytotoxicity 23/482 97/7206 6.11962079487e-08 ko04630 Jak-STAT signaling pathway 27/482 132/7206 1.20187089375e-07 ko05152 Tuberculosis 33/482 187/7206 1.9761046408e-07 ko05161 Hepatitis B 31/482 173/7206 3.28992555759e-07 ko04660 T cell receptor signaling pathway 25/482 124/7206 4.74922228861e-07 ko05133 Pertussis 20/482 87/7206 7.66530063198e-07 ko04668 TNF signaling pathway 24/482 120/7206 9.40974292353e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 32/482 191/7206 1.01650878958e-06 ko04622 RIG-I-like receptor signaling pathway 16/482 62/7206 1.93385758013e-06 ko05323 Rheumatoid arthritis 19/482 89/7206 4.72242114219e-06 ko05160 Hepatitis C 26/482 153/7206 8.1795511728e-06 ko04612 Antigen processing and presentation 17/482 77/7206 9.29782153396e-06 ko05320 Autoimmune thyroid disease 10/482 29/7206 1.02759455976e-05 ko05330 Allograft rejection 9/482 24/7206 1.31373881627e-05 ko05150 Staphylococcus aureus infection 11/482 36/7206 1.38690561273e-05 ko04662 B cell receptor signaling pathway 18/482 88/7206 1.57262109943e-05 ko05144 Malaria 12/482 45/7206 2.62943161148e-05 ko05142 Chagas disease (American trypanosomiasis) 22/482 130/7206 4.3358891943e-05 ko04623 Cytosolic DNA-sensing pathway 11/482 41/7206 5.36975888779e-05 ko05310 Asthma 7/482 17/7206 6.18575313561e-05 ko04640 Hematopoietic cell lineage 14/482 64/7206 6.36581316248e-05 ko05332 Graft-versus-host disease 7/482 18/7206 9.54301196242e-05 ko04210 Apoptosis 26/482 180/7206 0.000192144254557 ko04610 Complement and coagulation cascades 15/482 79/7206 0.000193371665454 ko00120 Primary bile acid biosynthesis 7/482 20/7206 0.000206655874185 ko00350 Tyrosine metabolism 9/482 33/7206 0.000225234151408 ko04062 Chemokine signaling pathway 28/482 201/7206 0.000246322650803 ko05034 Alcoholism 4/482 238/7206 0.000502679953362 ko04611 Platelet activation 23/482 163/7206 0.000631888514926 ko03040 Spliceosome 1/482 145/7206 0.00105724535326 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/482 4/7206 0.00113076437628 ko00140 Steroid hormone biosynthesis 9/482 41/7206 0.0012667496764 ko04657 IL-17 signaling pathway 14/482 87/7206 0.00174044653679 ko04080 Neuroactive ligand-receptor interaction 14/482 423/7206 0.00251475687708 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/482 5/7206 0.00268639663173 ko00950 Isoquinoline alkaloid biosynthesis 4/482 10/7206 0.00300077357228 ko05132 Salmonella infection 15/482 98/7206 0.00310267956999 ko05134 Legionellosis 12/482 74/7206 0.00340467067036 ko04145 Phagosome 21/482 162/7206 0.00349394906651 ko00360 Phenylalanine metabolism 5/482 17/7206 0.0041368184109 ko04940 Type I diabetes mellitus 7/482 32/7206 0.00445294845851 ko04933 AGE-RAGE signaling pathway in diabetic complications 18/482 135/7206 0.00453824357552 ko04666 Fc gamma R-mediated phagocytosis 17/482 122/7206 0.0049275922866 ko05166 HTLV-I infection 32/482 292/7206 0.00550864173076 ko05032 Morphine addiction 1/482 110/7206 0.00667872068552 ko05146 Amoebiasis 14/482 99/7206 0.00686637508456 ko00590 Arachidonic acid metabolism 9/482 52/7206 0.00691462591286 ko00592 alpha-Linolenic acid metabolism 5/482 19/7206 0.00695601330301 ko04390 Hippo signaling pathway 4/482 188/7206 0.00715801109004 ko04310 Wnt signaling pathway 4/482 181/7206 0.00982140302601 ko04068 FoxO signaling pathway 20/482 167/7206 0.0109358443361 ko05131 Shigellosis 12/482 82/7206 0.0112287072889 ko01200 Carbon metabolism 2/482 128/7206 0.0118865462828 ko04723 Retrograde endocannabinoid signaling 4/482 175/7206 0.013486208053 ko04260 Cardiac muscle contraction 1/482 98/7206 0.0141139747762 ko04664 Fc epsilon RI signaling pathway 11/482 77/7206 0.0175337320418 ko00190 Oxidative phosphorylation 2/482 127/7206 0.0176621281481 ko04360 Axon guidance 7/482 233/7206 0.0222053586063 ko04137 Mitophagy - animal 11/482 82/7206 0.0232592752438 ko00643 Styrene degradation 2/482 4/7206 0.0244717300088 ko05416 Viral myocarditis 8/482 55/7206 0.0286103823533 ko05169 Epstein-Barr virus infection 22/482 206/7206 0.0320427715989 ko05012 Parkinson's disease 4/482 155/7206 0.0339588784714 ko05016 Huntington's disease 7/482 215/7206 0.0372992558814 ko00281 Geraniol degradation 2/482 5/7206 0.0389952855939 ko04512 ECM-receptor interaction 10/482 79/7206 0.0409152746242 ko04721 Synaptic vesicle cycle 1/482 80/7206 0.0427372618334 ko05020 Prion diseases 6/482 40/7206 0.0479976015333