ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 25/261 191/7206 1.85311465443e-08 ko05164 Influenza A 23/261 167/7206 2.68978240187e-08 ko04380 Osteoclast differentiation 20/261 134/7206 5.78624930682e-08 ko05162 Measles 17/261 120/7206 1.25632404288e-06 ko04064 NF-kappa B signaling pathway 15/261 96/7206 1.52445906716e-06 ko04658 Th1 and Th2 cell differentiation 14/261 96/7206 7.88997102258e-06 ko05168 Herpes simplex infection 20/261 182/7206 8.29833350613e-06 ko04622 RIG-I-like receptor signaling pathway 11/261 62/7206 1.12285395284e-05 ko04623 Cytosolic DNA-sensing pathway 9/261 41/7206 1.18350058367e-05 ko04621 NOD-like receptor signaling pathway 18/261 157/7206 1.3229347489e-05 ko05145 Toxoplasmosis 15/261 126/7206 4.52198508665e-05 ko00120 Primary bile acid biosynthesis 6/261 20/7206 5.38359531827e-05 ko05340 Primary immunodeficiency 7/261 30/7206 7.50874593877e-05 ko05160 Hepatitis C 16/261 153/7206 0.000122986351678 ko00350 Tyrosine metabolism 7/261 33/7206 0.000143558621661 ko04660 T cell receptor signaling pathway 14/261 124/7206 0.000144720556449 ko05161 Hepatitis B 17/261 173/7206 0.000163530148904 ko00643 Styrene degradation 3/261 4/7206 0.000182913301629 ko04620 Toll-like receptor signaling pathway 12/261 100/7206 0.000242978579423 ko04672 Intestinal immune network for IgA production 7/261 37/7206 0.000305640463961 ko04668 TNF signaling pathway 13/261 120/7206 0.00037599531916 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/261 5/7206 0.000445020140776 ko00140 Steroid hormone biosynthesis 7/261 41/7206 0.000589760807566 ko04630 Jak-STAT signaling pathway 13/261 132/7206 0.000939683615881 ko05323 Rheumatoid arthritis 10/261 89/7206 0.00133435346307 ko05140 Leishmaniasis 9/261 75/7206 0.00144777033623 ko04659 Th17 cell differentiation 11/261 106/7206 0.00150160942958 ko05150 Staphylococcus aureus infection 6/261 36/7206 0.00166235115251 ko04612 Antigen processing and presentation 9/261 77/7206 0.00174628075516 ko04217 Necroptosis 15/261 178/7206 0.00193953860083 ko05167 Kaposi's sarcoma-associated herpesvirus infection 16/261 191/7206 0.00226285310358 ko04650 Natural killer cell mediated cytotoxicity 10/261 97/7206 0.00256202437768 ko00360 Phenylalanine metabolism 4/261 17/7206 0.00275619363751 ko04062 Chemokine signaling pathway 16/261 201/7206 0.00303170522562 ko04210 Apoptosis 15/261 180/7206 0.00336421487511 ko00051 Fructose and mannose metabolism 6/261 42/7206 0.00373469323481 ko05321 Inflammatory bowel disease (IBD) 7/261 56/7206 0.00383457751296 ko04657 IL-17 signaling pathway 9/261 87/7206 0.00405729691899 ko05133 Pertussis 9/261 87/7206 0.00405729691899 ko00950 Isoquinoline alkaloid biosynthesis 3/261 10/7206 0.00466497121713 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/261 4/7206 0.00747130502173 ko04610 Complement and coagulation cascades 8/261 79/7206 0.00751043945724 ko05131 Shigellosis 8/261 82/7206 0.00935278324697 ko04080 Neuroactive ligand-receptor interaction 6/261 423/7206 0.0100267142384 ko05330 Allograft rejection 4/261 24/7206 0.0100862881042 ko00590 Arachidonic acid metabolism 6/261 52/7206 0.0107330731871 ko05034 Alcoholism 2/261 238/7206 0.0126186228608 ko04666 Fc gamma R-mediated phagocytosis 10/261 122/7206 0.0127816398366 ko04662 B cell receptor signaling pathway 8/261 88/7206 0.0140208381554 ko04728 Dopaminergic synapse 1/261 185/7206 0.0151764443183 ko04390 Hippo signaling pathway 1/261 188/7206 0.0154578737703 ko04611 Platelet activation 12/261 163/7206 0.0172883464041 ko05320 Autoimmune thyroid disease 4/261 29/7206 0.0195809970194 ko05144 Malaria 5/261 45/7206 0.0224777130302 ko05132 Salmonella infection 8/261 98/7206 0.0252598735891 ko05152 Tuberculosis 13/261 187/7206 0.0255539150694 ko05332 Graft-versus-host disease 3/261 18/7206 0.0256182856136 ko05142 Chagas disease (American trypanosomiasis) 10/261 130/7206 0.0271404957204 ko03013 RNA transport 1/261 166/7206 0.0321659229175 ko00401 Novobiocin biosynthesis 1/261 1/7206 0.0362198168194 ko04724 Glutamatergic synapse 1/261 152/7206 0.0454208345198 ko05012 Parkinson's disease 1/261 155/7206 0.0462378786796 ko00920 Sulfur metabolism 2/261 10/7206 0.0485406147049 ko04360 Axon guidance 3/261 233/7206 0.0491995339574