ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 71/421 145/7206 5.16938278355e-50 ko03008 Ribosome biogenesis in eukaryotes 47/421 79/7206 2.10889058918e-38 ko03013 RNA transport 56/421 166/7206 6.10154087937e-29 ko03020 RNA polymerase 16/421 29/7206 4.69391027781e-13 ko03015 mRNA surveillance pathway 25/421 93/7206 5.41966236063e-11 ko03030 DNA replication 15/421 38/7206 1.10276514042e-09 ko00240 Pyrimidine metabolism 25/421 110/7206 2.58788104876e-09 ko03050 Proteasome 14/421 54/7206 1.63722473373e-06 ko04110 Cell cycle 24/421 145/7206 2.88220189071e-06 ko03010 Ribosome 21/421 129/7206 1.5740764687e-05 ko05169 Epstein-Barr virus infection 28/421 206/7206 2.53329863459e-05 ko03060 Protein export 8/421 23/7206 2.85888984035e-05 ko03018 RNA degradation 14/421 84/7206 0.000319345582693 ko04144 Endocytosis 6/421 342/7206 0.000325862186623 ko04024 cAMP signaling pathway 4/421 279/7206 0.00036505993134 ko04113 Meiosis - yeast 12/421 70/7206 0.00065073389855 ko04111 Cell cycle - yeast 14/421 90/7206 0.000659813560525 ko05010 Alzheimer's disease 2/421 202/7206 0.000699402271484 ko00230 Purine metabolism 23/421 194/7206 0.00097879868086 ko03420 Nucleotide excision repair 9/421 46/7206 0.00115811279768 ko05012 Parkinson's disease 1/421 155/7206 0.00151713054584 ko04022 cGMP-PKG signaling pathway 3/421 216/7206 0.0017591833071 ko04623 Cytosolic DNA-sensing pathway 8/421 41/7206 0.00220242647754 ko04142 Lysosome 1/421 151/7206 0.00228098065614 ko04724 Glutamatergic synapse 1/421 152/7206 0.00232203875847 ko04810 Regulation of actin cytoskeleton 5/421 264/7206 0.00292363174382 ko04723 Retrograde endocannabinoid signaling 2/421 175/7206 0.00296830130468 ko05168 Herpes simplex infection 21/421 182/7206 0.00325233457126 ko04261 Adrenergic signaling in cardiomyocytes 3/421 205/7206 0.00356058942563 ko04360 Axon guidance 4/421 233/7206 0.00395369730918 ko04380 Osteoclast differentiation 1/421 134/7206 0.00471006645519 ko04713 Circadian entrainment 1/421 136/7206 0.0047664562931 ko04015 Rap1 signaling pathway 6/421 278/7206 0.00559405326052 ko03410 Base excision repair 7/421 38/7206 0.00575652353912 ko04712 Circadian rhythm - plant 3/421 7/7206 0.00580708034773 ko04725 Cholinergic synapse 2/421 160/7206 0.00603881862161 ko04010 MAPK signaling pathway 8/421 321/7206 0.00687343187207 ko05142 Chagas disease (American trypanosomiasis) 1/421 130/7206 0.00700169375502 ko04514 Cell adhesion molecules (CAMs) 1/421 130/7206 0.00700169375502 ko04630 Jak-STAT signaling pathway 1/421 132/7206 0.00723870755832 ko03430 Mismatch repair 5/421 22/7206 0.00764954331807 ko05200 Pathways in cancer 16/421 492/7206 0.00930912990109 ko04668 TNF signaling pathway 1/421 120/7206 0.00995255135695 ko04062 Chemokine signaling pathway 4/421 201/7206 0.0137746232078 ko04151 PI3K-Akt signaling pathway 12/421 390/7206 0.0141647742683 ko04916 Melanogenesis 2/421 142/7206 0.0173278026947 ko04068 FoxO signaling pathway 3/421 167/7206 0.0184704292697 ko04139 Mitophagy - yeast 6/421 37/7206 0.0190730922782 ko05322 Systemic lupus erythematosus 16/421 151/7206 0.0204639064887 ko04727 GABAergic synapse 1/421 110/7206 0.0214954784511 ko05032 Morphine addiction 1/421 110/7206 0.0214954784511 ko04070 Phosphatidylinositol signaling system 1/421 112/7206 0.0222453637641 ko04510 Focal adhesion 6/421 240/7206 0.0238112744343 ko04726 Serotonergic synapse 2/421 137/7206 0.0248900003357 ko04728 Dopaminergic synapse 4/421 185/7206 0.0254599777795 ko04145 Phagosome 3/421 162/7206 0.0258172966184 ko04014 Ras signaling pathway 8/421 279/7206 0.0265615546011 ko05100 Bacterial invasion of epithelial cells 1/421 99/7206 0.030169053733 ko04620 Toll-like receptor signaling pathway 1/421 100/7206 0.0302211996666 ko05145 Toxoplasmosis 2/421 126/7206 0.0340084100633 ko01200 Carbon metabolism 2/421 128/7206 0.0343029617887 ko04371 Apelin signaling pathway 4/421 177/7206 0.0344702074818 ko04670 Leukocyte transendothelial migration 3/421 151/7206 0.0350304189193 ko04932 Non-alcoholic fatty liver disease (NAFLD) 4/421 182/7206 0.0352798844906 ko00970 Aminoacyl-tRNA biosynthesis 6/421 44/7206 0.041209430209 ko05120 Epithelial cell signaling in Helicobacter pylori infection 1/421 92/7206 0.0434807153623 ko04650 Natural killer cell mediated cytotoxicity 1/421 97/7206 0.0452118572352 ko05132 Salmonella infection 1/421 98/7206 0.0459718206506 ko04912 GnRH signaling pathway 2/421 122/7206 0.0484091615083 ko04666 Fc gamma R-mediated phagocytosis 2/421 122/7206 0.0484091615083