ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	203/1201	423/7206	2.15964186858e-54
ko05033	Nicotine addiction	49/1201	56/7206	2.25877283749e-31
ko04724	Glutamatergic synapse	88/1201	152/7206	2.48145378186e-31
ko05032	Morphine addiction	69/1201	110/7206	9.86273592885e-28
ko04727	GABAergic synapse	67/1201	110/7206	7.16511278633e-26
ko04713	Circadian entrainment	75/1201	136/7206	5.52247396171e-25
ko04721	Synaptic vesicle cycle	52/1201	80/7206	3.20978658419e-22
ko04728	Dopaminergic synapse	85/1201	185/7206	3.9235610457e-21
ko04725	Cholinergic synapse	75/1201	160/7206	2.13005839044e-19
ko04024	cAMP signaling pathway	107/1201	279/7206	6.94183287624e-19
ko04723	Retrograde endocannabinoid signaling	78/1201	175/7206	1.69183749531e-18
ko04020	Calcium signaling pathway	102/1201	265/7206	3.96275227301e-18
ko04742	Taste transduction	38/1201	61/7206	1.17854916121e-15
ko04911	Insulin secretion	55/1201	117/7206	1.3229163609e-14
ko04744	Phototransduction	27/1201	36/7206	1.5366836033e-14
ko04726	Serotonergic synapse	59/1201	137/7206	1.81420425322e-13
ko04921	Oxytocin signaling pathway	77/1201	209/7206	1.01550957669e-12
ko04261	Adrenergic signaling in cardiomyocytes	76/1201	205/7206	1.21612099506e-12
ko03040	Spliceosome	1/1201	145/7206	1.1769412979e-10
ko05031	Amphetamine addiction	41/1201	91/7206	1.70688705494e-10
ko04970	Salivary secretion	42/1201	95/7206	2.13452894757e-10
ko04720	Long-term potentiation	43/1201	99/7206	2.60403539708e-10
ko05203	Viral carcinogenesis	13/1201	277/7206	9.83161735417e-10
ko04360	Axon guidance	73/1201	233/7206	1.79323283384e-08
ko04060	Cytokine-cytokine receptor interaction	8/1201	191/7206	1.12073744653e-07
ko04022	cGMP-PKG signaling pathway	67/1201	216/7206	1.26618855389e-07
ko05322	Systemic lupus erythematosus	5/1201	151/7206	3.80514262805e-07
ko04971	Gastric acid secretion	37/1201	98/7206	3.95749022189e-07
ko04925	Aldosterone synthesis and secretion	39/1201	105/7206	3.98182185348e-07
ko05168	Herpes simplex infection	8/1201	182/7206	4.93107907549e-07
ko04740	Olfactory transduction	32/1201	80/7206	5.13093898464e-07
ko05030	Cocaine addiction	30/1201	73/7206	5.83506079234e-07
ko03013	RNA transport	7/1201	166/7206	1.31375569938e-06
ko04966	Collecting duct acid secretion	15/1201	26/7206	2.4223346109e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1201	74/7206	1.06756427043e-05
ko04010	MAPK signaling pathway	84/1201	321/7206	1.07452288085e-05
ko04610	Complement and coagulation cascades	1/1201	79/7206	1.28298913377e-05
ko04120	Ubiquitin mediated proteolysis	6/1201	138/7206	1.38953871255e-05
ko04972	Pancreatic secretion	37/1201	111/7206	1.47007419386e-05
ko04070	Phosphatidylinositol signaling system	37/1201	112/7206	1.73067757291e-05
ko04514	Cell adhesion molecules (CAMs)	41/1201	130/7206	2.34988119096e-05
ko04540	Gap junction	40/1201	128/7206	3.63251645286e-05
ko05169	Epstein-Barr virus infection	14/1201	206/7206	3.72101313273e-05
ko04745	Phototransduction - fly	17/1201	38/7206	4.52918240183e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1201	79/7206	4.7162012846e-05
ko04621	NOD-like receptor signaling pathway	9/1201	157/7206	5.0556438711e-05
ko04141	Protein processing in endoplasmic reticulum	12/1201	184/7206	5.20857342537e-05
ko05164	Influenza A	10/1201	167/7206	5.2552089225e-05
ko04260	Cardiac muscle contraction	32/1201	98/7206	9.39050399282e-05
ko04730	Long-term depression	27/1201	78/7206	9.46273284381e-05
ko04924	Renin secretion	29/1201	86/7206	0.000103856350305
ko03008	Ribosome biogenesis in eukaryotes	2/1201	79/7206	0.000111566717116
ko05110	Vibrio cholerae infection	23/1201	63/7206	0.000120674471098
ko04072	Phospholipase D signaling pathway	53/1201	197/7206	0.000212633172234
ko05140	Leishmaniasis	2/1201	75/7206	0.000248812989911
ko04064	NF-kappa B signaling pathway	4/1201	96/7206	0.000271176870146
ko05414	Dilated cardiomyopathy	34/1201	112/7206	0.000282957828984
ko04014	Ras signaling pathway	69/1201	279/7206	0.000409650408354
ko05205	Proteoglycans in cancer	25/1201	271/7206	0.00045654678547
ko04110	Cell cycle	10/1201	145/7206	0.000668207280543
ko04750	Inflammatory mediator regulation of TRP channels	35/1201	122/7206	0.000814073919146
ko04612	Antigen processing and presentation	3/1201	77/7206	0.00101972370202
ko04626	Plant-pathogen interaction	9/1201	18/7206	0.00111292680059
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1201	59/7206	0.00118675669843
ko04976	Bile secretion	25/1201	80/7206	0.0012432157156
ko05161	Hepatitis B	14/1201	173/7206	0.00128590899584
ko05162	Measles	8/1201	120/7206	0.00181557284579
ko00240	Pyrimidine metabolism	7/1201	110/7206	0.00183421507044
ko04915	Estrogen signaling pathway	36/1201	131/7206	0.00187059584798
ko04146	Peroxisome	5/1201	89/7206	0.00250146543635
ko00330	Arginine and proline metabolism	2/1201	61/7206	0.00271358998257
ko04371	Apelin signaling pathway	45/1201	177/7206	0.00286031696596
ko00260	Glycine, serine and threonine metabolism	1/1201	48/7206	0.0029033992784
ko04923	Regulation of lipolysis in adipocytes	23/1201	77/7206	0.00327867159955
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1201	14/7206	0.0040705727587
ko05144	Malaria	1/1201	45/7206	0.00434272987093
ko00071	Fatty acid degradation	1/1201	45/7206	0.00434272987093
ko03420	Nucleotide excision repair	1/1201	46/7206	0.00443889708039
ko03018	RNA degradation	5/1201	84/7206	0.00490263547615
ko04964	Proximal tubule bicarbonate reclamation	11/1201	29/7206	0.00493010599677
ko00480	Glutathione metabolism	2/1201	55/7206	0.00563633621329
ko05321	Inflammatory bowel disease (IBD)	2/1201	56/7206	0.00584536102288
ko04640	Hematopoietic cell lineage	3/1201	64/7206	0.00637445716767
ko00310	Lysine degradation	4/1201	73/7206	0.00674310083369
ko03022	Basal transcription factors	1/1201	44/7206	0.00683109043593
ko05131	Shigellosis	5/1201	82/7206	0.00683750734484
ko00590	Arachidonic acid metabolism	2/1201	52/7206	0.00819011832257
ko04630	Jak-STAT signaling pathway	11/1201	132/7206	0.00896323589773
ko04330	Notch signaling pathway	3/1201	62/7206	0.00922589803685
ko04622	RIG-I-like receptor signaling pathway	3/1201	62/7206	0.00922589803685
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1201	100/7206	0.00948122503933
ko04214	Apoptosis - fly	4/1201	72/7206	0.00988146310697
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1201	182/7206	0.0115017187056
ko00380	Tryptophan metabolism	2/1201	50/7206	0.0120350355485
ko04658	Th1 and Th2 cell differentiation	7/1201	96/7206	0.0122230468494
ko04657	IL-17 signaling pathway	6/1201	87/7206	0.012910337286
ko05133	Pertussis	6/1201	87/7206	0.012910337286
ko01524	Platinum drug resistance	5/1201	76/7206	0.0131479164957
ko00630	Glyoxylate and dicarboxylate metabolism	1/1201	38/7206	0.0147565462936
ko05145	Toxoplasmosis	11/1201	126/7206	0.0152152531717
ko04115	p53 signaling pathway	5/1201	74/7206	0.0180927523653
ko05166	HTLV-I infection	34/1201	292/7206	0.0197533898695
ko04916	Melanogenesis	34/1201	142/7206	0.022721778483
ko05418	Fluid shear stress and atherosclerosis	18/1201	173/7206	0.0230174856293
ko04210	Apoptosis	19/1201	180/7206	0.0254734017139
ko05215	Prostate cancer	10/1201	111/7206	0.0284793641142
ko00562	Inositol phosphate metabolism	23/1201	89/7206	0.030324933956
ko04015	Rap1 signaling pathway	60/1201	278/7206	0.0324076178443
ko05231	Choline metabolism in cancer	32/1201	134/7206	0.0341958500501
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1201	92/7206	0.0350066566449
ko04912	GnRH signaling pathway	29/1201	122/7206	0.0374665220723
ko04918	Thyroid hormone synthesis	22/1201	86/7206	0.0398795095876
ko04930	Type II diabetes mellitus	15/1201	54/7206	0.041175738185
ko04620	Toll-like receptor signaling pathway	9/1201	100/7206	0.0415657024863
ko04270	Vascular smooth muscle contraction	35/1201	154/7206	0.0485554111995