ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 205/1235 423/7206 1.10507638753e-53 ko04724 Glutamatergic synapse 91/1235 152/7206 5.47124745146e-33 ko05033 Nicotine addiction 49/1235 56/7206 8.77252424269e-31 ko04713 Circadian entrainment 79/1235 136/7206 1.70556212811e-27 ko05032 Morphine addiction 68/1235 110/7206 4.77700582785e-26 ko04727 GABAergic synapse 67/1235 110/7206 3.8554577188e-25 ko04721 Synaptic vesicle cycle 52/1235 80/7206 1.21066919856e-21 ko04728 Dopaminergic synapse 87/1235 185/7206 1.30825371413e-21 ko04725 Cholinergic synapse 77/1235 160/7206 5.3532175172e-20 ko04020 Calcium signaling pathway 104/1235 265/7206 2.54525200319e-18 ko04024 cAMP signaling pathway 107/1235 279/7206 8.6300492953e-18 ko04723 Retrograde endocannabinoid signaling 78/1235 175/7206 9.30783609506e-18 ko04744 Phototransduction 29/1235 36/7206 1.11859383248e-16 ko04726 Serotonergic synapse 63/1235 137/7206 2.3070428574e-15 ko04742 Taste transduction 38/1235 61/7206 3.05016199909e-15 ko04921 Oxytocin signaling pathway 83/1235 209/7206 3.64174032438e-15 ko04911 Insulin secretion 55/1235 117/7206 4.50853871444e-14 ko04720 Long-term potentiation 48/1235 99/7206 4.48177208534e-13 ko05031 Amphetamine addiction 45/1235 91/7206 1.00407672874e-12 ko04970 Salivary secretion 46/1235 95/7206 1.47302809719e-12 ko04740 Olfactory transduction 41/1235 80/7206 2.31039031263e-12 ko04261 Adrenergic signaling in cardiomyocytes 74/1235 205/7206 4.36215304105e-11 ko03040 Spliceosome 1/1235 145/7206 7.34622145478e-11 ko04925 Aldosterone synthesis and secretion 43/1235 105/7206 8.13950591241e-09 ko04971 Gastric acid secretion 40/1235 98/7206 3.0983385028e-08 ko05168 Herpes simplex infection 7/1235 182/7206 4.02869673965e-08 ko05203 Viral carcinogenesis 17/1235 277/7206 5.37906875723e-08 ko04060 Cytokine-cytokine receptor interaction 9/1235 191/7206 2.5679951739e-07 ko04120 Ubiquitin mediated proteolysis 4/1235 138/7206 2.60958660516e-07 ko05030 Cocaine addiction 31/1235 73/7206 2.98227352522e-07 ko04540 Gap junction 46/1235 128/7206 3.01356243027e-07 ko04022 cGMP-PKG signaling pathway 67/1235 216/7206 3.27913706781e-07 ko03013 RNA transport 7/1235 166/7206 5.76992647305e-07 ko05322 Systemic lupus erythematosus 6/1235 151/7206 9.74053714751e-07 ko04621 NOD-like receptor signaling pathway 7/1235 157/7206 1.69261433345e-06 ko04924 Renin secretion 33/1235 86/7206 2.09469072961e-06 ko04745 Phototransduction - fly 19/1235 38/7206 3.18757955421e-06 ko04360 Axon guidance 68/1235 233/7206 3.43514928195e-06 ko04966 Collecting duct acid secretion 15/1235 26/7206 3.48538588066e-06 ko04070 Phosphatidylinositol signaling system 39/1235 112/7206 5.59278813022e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 29/1235 74/7206 5.93916295023e-06 ko05164 Influenza A 9/1235 167/7206 9.19355535481e-06 ko04110 Cell cycle 7/1235 145/7206 1.03886313241e-05 ko04514 Cell adhesion molecules (CAMs) 42/1235 130/7206 1.80914107111e-05 ko04730 Long-term depression 29/1235 78/7206 2.38001858222e-05 ko04141 Protein processing in endoplasmic reticulum 12/1235 184/7206 2.62728333509e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 29/1235 79/7206 2.82204617348e-05 ko04010 MAPK signaling pathway 84/1235 321/7206 2.83594646825e-05 ko04972 Pancreatic secretion 37/1235 111/7206 3.26638262682e-05 ko04626 Plant-pathogen interaction 11/1235 18/7206 3.524001946e-05 ko05169 Epstein-Barr virus infection 15/1235 206/7206 4.63705548824e-05 ko04750 Inflammatory mediator regulation of TRP channels 39/1235 122/7206 4.94440787827e-05 ko04260 Cardiac muscle contraction 33/1235 98/7206 6.31143240014e-05 ko04014 Ras signaling pathway 74/1235 279/7206 6.3339458574e-05 ko05110 Vibrio cholerae infection 24/1235 63/7206 6.34708380216e-05 ko04612 Antigen processing and presentation 2/1235 77/7206 0.00010696310936 ko04610 Complement and coagulation cascades 2/1235 79/7206 0.000114108472298 ko03008 Ribosome biogenesis in eukaryotes 2/1235 79/7206 0.000114108472298 ko05140 Leishmaniasis 2/1235 75/7206 0.000159677569949 ko04064 NF-kappa B signaling pathway 4/1235 96/7206 0.000180722810947 ko05414 Dilated cardiomyopathy 35/1235 112/7206 0.000204832229668 ko05205 Proteoglycans in cancer 25/1235 271/7206 0.000204996469978 ko04214 Apoptosis - fly 2/1235 72/7206 0.000238730630648 ko04976 Bile secretion 27/1235 80/7206 0.00026434134442 ko05162 Measles 7/1235 120/7206 0.000340528147848 ko04072 Phospholipase D signaling pathway 53/1235 197/7206 0.000505926418462 ko04371 Apelin signaling pathway 48/1235 177/7206 0.000780511767913 ko00520 Amino sugar and nucleotide sugar metabolism 1/1235 55/7206 0.000862840163006 ko05166 HTLV-I infection 30/1235 292/7206 0.001093579733 ko04915 Estrogen signaling pathway 37/1235 131/7206 0.00142042528653 ko04961 Endocrine and other factor-regulated calcium reabsorption 20/1235 59/7206 0.00151678424579 ko04964 Proximal tubule bicarbonate reclamation 12/1235 29/7206 0.00180113789431 ko04922 Glucagon signaling pathway 36/1235 128/7206 0.00187775094986 ko05161 Hepatitis B 15/1235 173/7206 0.00202856186768 ko04923 Regulation of lipolysis in adipocytes 24/1235 77/7206 0.00212458418085 ko04657 IL-17 signaling pathway 5/1235 87/7206 0.00243142553843 ko03420 Nucleotide excision repair 1/1235 46/7206 0.00281202663475 ko03018 RNA degradation 5/1235 84/7206 0.00342677963952 ko00480 Glutathione metabolism 2/1235 55/7206 0.00372990676965 ko05321 Inflammatory bowel disease (IBD) 2/1235 56/7206 0.00375406815843 ko05145 Toxoplasmosis 10/1235 126/7206 0.00397000162865 ko03022 Basal transcription factors 1/1235 44/7206 0.00424575375016 ko05144 Malaria 1/1235 45/7206 0.00438407243482 ko00071 Fatty acid degradation 1/1235 45/7206 0.00438407243482 ko00310 Lysine degradation 4/1235 73/7206 0.00465566429267 ko05131 Shigellosis 5/1235 82/7206 0.00478731161776 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/1235 14/7206 0.00478960812332 ko04912 GnRH signaling pathway 33/1235 122/7206 0.00514441118852 ko04330 Notch signaling pathway 3/1235 62/7206 0.00621975089561 ko04622 RIG-I-like receptor signaling pathway 3/1235 62/7206 0.00621975089561 ko04146 Peroxisome 6/1235 89/7206 0.00662931847526 ko05410 Hypertrophic cardiomyopathy (HCM) 28/1235 100/7206 0.00690660407365 ko04932 Non-alcoholic fatty liver disease (NAFLD) 18/1235 182/7206 0.00696300006253 ko04668 TNF signaling pathway 10/1235 120/7206 0.00707765339915 ko04350 TGF-beta signaling pathway 8/1235 103/7206 0.0081731348487 ko00562 Inositol phosphate metabolism 25/1235 89/7206 0.0100267928635 ko00240 Pyrimidine metabolism 9/1235 110/7206 0.0102468202241 ko04115 p53 signaling pathway 5/1235 74/7206 0.0128991410252 ko00630 Glyoxylate and dicarboxylate metabolism 1/1235 38/7206 0.0150836685814 ko00290 Valine, leucine and isoleucine biosynthesis 3/1235 4/7206 0.0175178299579 ko04978 Mineral absorption 13/1235 40/7206 0.0179988983118 ko00600 Sphingolipid metabolism 4/1235 63/7206 0.0182704061519 ko05418 Fluid shear stress and atherosclerosis 18/1235 173/7206 0.0182809112808 ko04658 Th1 and Th2 cell differentiation 8/1235 96/7206 0.0197359508019 ko04217 Necroptosis 19/1235 178/7206 0.0201145473029 ko05215 Prostate cancer 10/1235 111/7206 0.0215770474747 ko04916 Melanogenesis 35/1235 142/7206 0.023709438007 ko04630 Jak-STAT signaling pathway 13/1235 132/7206 0.0260080825322 ko04930 Type II diabetes mellitus 16/1235 54/7206 0.0272481490285 ko04142 Lysosome 16/1235 151/7206 0.028993554972 ko05202 Transcriptional misregulation in cancer 21/1235 188/7206 0.0303648181312 ko01524 Platinum drug resistance 6/1235 76/7206 0.0311913057229 ko04620 Toll-like receptor signaling pathway 9/1235 100/7206 0.0314557192716 ko05217 Basal cell carcinoma 5/1235 68/7206 0.0339068307236 ko05214 Glioma 21/1235 79/7206 0.0342094757124 ko04015 Rap1 signaling pathway 61/1235 278/7206 0.0346016296001 ko05200 Pathways in cancer 67/1235 492/7206 0.0348750247405 ko00980 Metabolism of xenobiotics by cytochrome P450 2/1235 40/7206 0.0359029484054 ko05212 Pancreatic cancer 7/1235 83/7206 0.0387553078541 ko04114 Oocyte meiosis 33/1235 139/7206 0.0408673929717 ko05132 Salmonella infection 9/1235 98/7206 0.0415340538202 ko04640 Hematopoietic cell lineage 5/1235 64/7206 0.0454651391306 ko05133 Pertussis 8/1235 87/7206 0.045502281356 ko05222 Small cell lung cancer 8/1235 89/7206 0.0460783339977 ko05320 Autoimmune thyroid disease 1/1235 29/7206 0.0481126807447 ko05231 Choline metabolism in cancer 32/1235 134/7206 0.0481174180794 ko05340 Primary immunodeficiency 1/1235 30/7206 0.0487795387631