ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1249	423/7206	2.69019711981e-49
ko04724	Glutamatergic synapse	91/1249	152/7206	1.37711973659e-32
ko05033	Nicotine addiction	47/1249	56/7206	1.22665867636e-27
ko05032	Morphine addiction	70/1249	110/7206	1.33910977653e-27
ko04713	Circadian entrainment	78/1249	136/7206	2.58607808373e-26
ko04727	GABAergic synapse	67/1249	110/7206	7.58575625418e-25
ko04721	Synaptic vesicle cycle	52/1249	80/7206	2.06572532112e-21
ko04728	Dopaminergic synapse	87/1249	185/7206	2.87792648642e-21
ko04725	Cholinergic synapse	78/1249	160/7206	2.28038595296e-20
ko04024	cAMP signaling pathway	108/1249	279/7206	5.74705380764e-18
ko04723	Retrograde endocannabinoid signaling	78/1249	175/7206	1.84218659087e-17
ko04020	Calcium signaling pathway	103/1249	265/7206	1.98335398985e-17
ko04742	Taste transduction	39/1249	61/7206	5.33227339296e-16
ko04911	Insulin secretion	57/1249	117/7206	3.51093374011e-15
ko04921	Oxytocin signaling pathway	83/1249	209/7206	9.70687147233e-15
ko04726	Serotonergic synapse	62/1249	137/7206	1.69335946931e-14
ko04744	Phototransduction	27/1249	36/7206	4.1790669174e-14
ko04261	Adrenergic signaling in cardiomyocytes	77/1249	205/7206	3.07585355798e-12
ko04970	Salivary secretion	45/1249	95/7206	1.02002923664e-11
ko03040	Spliceosome	1/1249	145/7206	4.30465857837e-11
ko04720	Long-term potentiation	45/1249	99/7206	5.91272942138e-11
ko05031	Amphetamine addiction	42/1249	91/7206	1.42401812928e-10
ko04360	Axon guidance	76/1249	233/7206	9.44245617899e-09
ko04022	cGMP-PKG signaling pathway	71/1249	216/7206	2.34014375927e-08
ko05203	Viral carcinogenesis	17/1249	277/7206	3.78597344066e-08
ko04740	Olfactory transduction	34/1249	80/7206	1.03628745724e-07
ko04060	Cytokine-cytokine receptor interaction	9/1249	191/7206	1.72343453419e-07
ko04925	Aldosterone synthesis and secretion	40/1249	105/7206	3.29317590911e-07
ko03013	RNA transport	7/1249	166/7206	3.78721334745e-07
ko04971	Gastric acid secretion	38/1249	98/7206	4.85902767932e-07
ko05322	Systemic lupus erythematosus	6/1249	151/7206	6.51287684183e-07
ko04070	Phosphatidylinositol signaling system	41/1249	112/7206	8.54066887289e-07
ko05030	Cocaine addiction	30/1249	73/7206	2.2354119151e-06
ko05168	Herpes simplex infection	10/1249	182/7206	2.30003669724e-06
ko04010	MAPK signaling pathway	89/1249	321/7206	2.36441474002e-06
ko04924	Renin secretion	33/1249	86/7206	3.94791670114e-06
ko04966	Collecting duct acid secretion	15/1249	26/7206	4.03472136915e-06
ko04621	NOD-like receptor signaling pathway	8/1249	157/7206	5.55752378133e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1249	74/7206	7.1258141039e-06
ko04540	Gap junction	43/1249	128/7206	8.3127589629e-06
ko04514	Cell adhesion molecules (CAMs)	43/1249	130/7206	1.05340291763e-05
ko05164	Influenza A	10/1249	167/7206	1.79385194883e-05
ko04972	Pancreatic secretion	38/1249	111/7206	1.96394447766e-05
ko04120	Ubiquitin mediated proteolysis	7/1249	138/7206	2.08108399068e-05
ko04730	Long-term depression	29/1249	78/7206	2.6945181098e-05
ko04976	Bile secretion	29/1249	80/7206	4.08335433783e-05
ko04610	Complement and coagulation cascades	2/1249	79/7206	7.02406354714e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1249	79/7206	7.02406354714e-05
ko05110	Vibrio cholerae infection	24/1249	63/7206	7.42081219012e-05
ko04745	Phototransduction - fly	17/1249	38/7206	7.58451836211e-05
ko04072	Phospholipase D signaling pathway	56/1249	197/7206	8.1663685005e-05
ko04014	Ras signaling pathway	74/1249	279/7206	9.62683717864e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1249	79/7206	0.000121514698158
ko04110	Cell cycle	9/1249	145/7206	0.000133382375356
ko04141	Protein processing in endoplasmic reticulum	14/1249	184/7206	0.00015968935682
ko05140	Leishmaniasis	2/1249	75/7206	0.000160371156534
ko04064	NF-kappa B signaling pathway	4/1249	96/7206	0.000184096414262
ko04923	Regulation of lipolysis in adipocytes	27/1249	77/7206	0.000189508620969
ko04260	Cardiac muscle contraction	32/1249	98/7206	0.000216223097758
ko05169	Epstein-Barr virus infection	17/1249	206/7206	0.00024052735149
ko04371	Apelin signaling pathway	50/1249	177/7206	0.000260297965049
ko04626	Plant-pathogen interaction	10/1249	18/7206	0.000268367773434
ko05414	Dilated cardiomyopathy	35/1249	112/7206	0.000341944194754
ko04750	Inflammatory mediator regulation of TRP channels	37/1249	122/7206	0.000389867032043
ko05205	Proteoglycans in cancer	26/1249	271/7206	0.000401235932814
ko04964	Proximal tubule bicarbonate reclamation	13/1249	29/7206	0.000519974004273
ko04612	Antigen processing and presentation	3/1249	77/7206	0.000679894604359
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1249	59/7206	0.000736716820119
ko04915	Estrogen signaling pathway	38/1249	131/7206	0.000965400111439
ko04146	Peroxisome	5/1249	89/7206	0.00170946792965
ko03420	Nucleotide excision repair	1/1249	46/7206	0.0027879222877
ko05161	Hepatitis B	16/1249	173/7206	0.00308628802424
ko05162	Measles	9/1249	120/7206	0.00318871263203
ko00480	Glutathione metabolism	2/1249	55/7206	0.00369151848122
ko05321	Inflammatory bowel disease (IBD)	2/1249	56/7206	0.00379639623835
ko03022	Basal transcription factors	1/1249	44/7206	0.00424764501502
ko04922	Glucagon signaling pathway	35/1249	128/7206	0.00437793065698
ko05144	Malaria	1/1249	45/7206	0.0044793762753
ko00071	Fatty acid degradation	1/1249	45/7206	0.0044793762753
ko04214	Apoptosis - fly	4/1249	72/7206	0.00461637784756
ko00310	Lysine degradation	4/1249	73/7206	0.00463457972814
ko00562	Inositol phosphate metabolism	26/1249	89/7206	0.00465513901484
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1249	14/7206	0.00511318586066
ko00590	Arachidonic acid metabolism	2/1249	52/7206	0.00542518801706
ko00330	Arginine and proline metabolism	3/1249	61/7206	0.00616025327364
ko04330	Notch signaling pathway	3/1249	62/7206	0.00622891306353
ko04622	RIG-I-like receptor signaling pathway	3/1249	62/7206	0.00622891306353
ko04657	IL-17 signaling pathway	6/1249	87/7206	0.00653167750486
ko05133	Pertussis	6/1249	87/7206	0.00653167750486
ko04710	Circadian rhythm	15/1249	43/7206	0.0069524840526
ko00240	Pyrimidine metabolism	9/1249	110/7206	0.00758066522612
ko05145	Toxoplasmosis	11/1249	126/7206	0.00856836091812
ko00630	Glyoxylate and dicarboxylate metabolism	1/1249	38/7206	0.00956186555322
ko04930	Type II diabetes mellitus	17/1249	54/7206	0.0103332577655
ko05131	Shigellosis	6/1249	82/7206	0.012317278992
ko03018	RNA degradation	6/1249	84/7206	0.012698681223
ko04115	p53 signaling pathway	5/1249	74/7206	0.0128140048231
ko04918	Thyroid hormone synthesis	24/1249	86/7206	0.0140014300516
ko05166	HTLV-I infection	35/1249	292/7206	0.0141448914567
ko04015	Rap1 signaling pathway	64/1249	278/7206	0.015036784977
ko04711	Circadian rhythm - fly	6/1249	13/7206	0.0152200258413
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1249	100/7206	0.0157530081604
ko04217	Necroptosis	19/1249	178/7206	0.0158745250255
ko04640	Hematopoietic cell lineage	4/1249	64/7206	0.0186695701697
ko04630	Jak-STAT signaling pathway	13/1249	132/7206	0.0199632252127
ko04658	Th1 and Th2 cell differentiation	8/1249	96/7206	0.0199672012084
ko04912	GnRH signaling pathway	31/1249	122/7206	0.0216231919388
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1249	182/7206	0.022090039628
ko05231	Choline metabolism in cancer	33/1249	134/7206	0.0284757158142
ko04722	Neurotrophin signaling pathway	38/1249	160/7206	0.0344837524928
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1249	40/7206	0.0356047317483
ko00140	Steroid hormone biosynthesis	2/1249	41/7206	0.0360987290661
ko00380	Tryptophan metabolism	3/1249	50/7206	0.0368669083689
ko04973	Carbohydrate digestion and absorption	13/1249	42/7206	0.0375550364122
ko04916	Melanogenesis	34/1249	142/7206	0.0431694189299
ko05016	Huntington's disease	26/1249	215/7206	0.043625815041
ko04210	Apoptosis	21/1249	180/7206	0.0455270645784
ko05320	Autoimmune thyroid disease	1/1249	29/7206	0.0479021157841
ko05340	Primary immunodeficiency	1/1249	30/7206	0.0491008458135