ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	212/1300	423/7206	1.08075460519e-54
ko04724	Glutamatergic synapse	96/1300	152/7206	1.2778319838e-35
ko05033	Nicotine addiction	49/1300	56/7206	1.05539576859e-29
ko04713	Circadian entrainment	82/1300	136/7206	1.78024573936e-28
ko05032	Morphine addiction	72/1300	110/7206	2.25573346757e-28
ko04727	GABAergic synapse	70/1300	110/7206	1.70083931358e-26
ko04721	Synaptic vesicle cycle	54/1300	80/7206	1.60257954435e-22
ko04725	Cholinergic synapse	81/1300	160/7206	2.66358716245e-21
ko04728	Dopaminergic synapse	88/1300	185/7206	1.06123867352e-20
ko04020	Calcium signaling pathway	111/1300	265/7206	3.26369348587e-20
ko04723	Retrograde endocannabinoid signaling	81/1300	175/7206	3.16785864344e-18
ko04911	Insulin secretion	62/1300	117/7206	7.59040745884e-18
ko04024	cAMP signaling pathway	110/1300	279/7206	1.10876048989e-17
ko04726	Serotonergic synapse	67/1300	137/7206	8.3384463974e-17
ko04921	Oxytocin signaling pathway	87/1300	209/7206	6.27464880236e-16
ko04742	Taste transduction	39/1300	61/7206	2.16544835033e-15
ko04744	Phototransduction	28/1300	36/7206	7.93972181142e-15
ko04970	Salivary secretion	49/1300	95/7206	9.14571981765e-14
ko04720	Long-term potentiation	50/1300	99/7206	1.48804051939e-13
ko05031	Amphetamine addiction	46/1300	91/7206	1.36561518965e-12
ko04740	Olfactory transduction	41/1300	80/7206	1.29488508699e-11
ko03040	Spliceosome	1/1300	145/7206	1.62223445722e-11
ko04261	Adrenergic signaling in cardiomyocytes	77/1300	205/7206	1.83476067939e-11
ko04925	Aldosterone synthesis and secretion	46/1300	105/7206	6.75786004533e-10
ko04022	cGMP-PKG signaling pathway	75/1300	216/7206	2.5688871589e-09
ko04971	Gastric acid secretion	42/1300	98/7206	1.13078907678e-08
ko04540	Gap junction	50/1300	128/7206	1.70547719226e-08
ko05168	Herpes simplex infection	8/1300	182/7206	4.31248638723e-08
ko05203	Viral carcinogenesis	19/1300	277/7206	6.64390931044e-08
ko03013	RNA transport	7/1300	166/7206	1.0938963814e-07
ko04360	Axon guidance	75/1300	233/7206	1.30492199327e-07
ko05030	Cocaine addiction	32/1300	73/7206	2.6764749283e-07
ko04972	Pancreatic secretion	42/1300	111/7206	6.3568965302e-07
ko04060	Cytokine-cytokine receptor interaction	11/1300	191/7206	7.94882323235e-07
ko04966	Collecting duct acid secretion	16/1300	26/7206	9.89597634001e-07
ko05322	Systemic lupus erythematosus	7/1300	151/7206	1.56927408813e-06
ko04730	Long-term depression	32/1300	78/7206	1.7847377568e-06
ko04924	Renin secretion	34/1300	86/7206	2.78594118549e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1300	74/7206	4.93852852508e-06
ko05164	Influenza A	10/1300	167/7206	8.72192109844e-06
ko04070	Phosphatidylinositol signaling system	40/1300	112/7206	8.86917270256e-06
ko04120	Ubiquitin mediated proteolysis	7/1300	138/7206	9.42032660191e-06
ko04514	Cell adhesion molecules (CAMs)	44/1300	130/7206	1.4099181797e-05
ko04010	MAPK signaling pathway	89/1300	321/7206	1.43030083196e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	25/1300	59/7206	1.8847457166e-05
ko04141	Protein processing in endoplasmic reticulum	13/1300	184/7206	2.40182832102e-05
ko04621	NOD-like receptor signaling pathway	10/1300	157/7206	3.32967875354e-05
ko04750	Inflammatory mediator regulation of TRP channels	41/1300	122/7206	3.86414642586e-05
ko04110	Cell cycle	9/1300	145/7206	4.44885063091e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1300	79/7206	4.46027914921e-05
ko05110	Vibrio cholerae infection	25/1300	63/7206	4.67467558493e-05
ko04976	Bile secretion	30/1300	80/7206	4.77926769476e-05
ko04072	Phospholipase D signaling pathway	58/1300	197/7206	6.93070299295e-05
ko05169	Epstein-Barr virus infection	17/1300	206/7206	9.68894966778e-05
ko04745	Phototransduction - fly	17/1300	38/7206	0.00012742670166
ko04923	Regulation of lipolysis in adipocytes	28/1300	77/7206	0.000130878056026
ko05162	Measles	7/1300	120/7206	0.000163995330308
ko04014	Ras signaling pathway	75/1300	279/7206	0.000178572979624
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1300	79/7206	0.000186199251308
ko05414	Dilated cardiomyopathy	36/1300	112/7206	0.000271718583333
ko00520	Amino sugar and nucleotide sugar metabolism	1/1300	55/7206	0.000330800191718
ko04371	Apelin signaling pathway	51/1300	177/7206	0.000339375170482
ko04260	Cardiac muscle contraction	32/1300	98/7206	0.000471294252247
ko00240	Pyrimidine metabolism	7/1300	110/7206	0.000632339374991
ko04964	Proximal tubule bicarbonate reclamation	13/1300	29/7206	0.000775251657387
ko04915	Estrogen signaling pathway	39/1300	131/7206	0.000830352062656
ko05205	Proteoglycans in cancer	29/1300	271/7206	0.000917440327501
ko04610	Complement and coagulation cascades	4/1300	79/7206	0.00106141938735
ko04146	Peroxisome	5/1300	89/7206	0.00118921720006
ko04064	NF-kappa B signaling pathway	6/1300	96/7206	0.00120157613465
ko04612	Antigen processing and presentation	4/1300	77/7206	0.00152711748091
ko03420	Nucleotide excision repair	1/1300	46/7206	0.00176465398423
ko04626	Plant-pathogen interaction	9/1300	18/7206	0.00199919200728
ko05140	Leishmaniasis	4/1300	75/7206	0.00220044667862
ko00480	Glutathione metabolism	2/1300	55/7206	0.00240246698806
ko03022	Basal transcription factors	1/1300	44/7206	0.00267294398323
ko05144	Malaria	1/1300	45/7206	0.00275082392678
ko00071	Fatty acid degradation	1/1300	45/7206	0.00275082392678
ko04214	Apoptosis - fly	4/1300	72/7206	0.00312220988546
ko00310	Lysine degradation	4/1300	73/7206	0.00317400031649
ko04912	GnRH signaling pathway	35/1300	122/7206	0.00401468498076
ko04622	RIG-I-like receptor signaling pathway	3/1300	62/7206	0.0041759021388
ko05133	Pertussis	6/1300	87/7206	0.00459162934282
ko05145	Toxoplasmosis	11/1300	126/7206	0.00472517022917
ko04922	Glucagon signaling pathway	36/1300	128/7206	0.00500043818875
ko05166	HTLV-I infection	35/1300	292/7206	0.0050643716529
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1300	182/7206	0.00600880522161
ko05231	Choline metabolism in cancer	37/1300	134/7206	0.00611071856593
ko03018	RNA degradation	6/1300	84/7206	0.00631818499865
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1300	14/7206	0.00643948502829
ko04918	Thyroid hormone synthesis	26/1300	86/7206	0.00664662744633
ko05161	Hepatitis B	18/1300	173/7206	0.0066969996539
ko04270	Vascular smooth muscle contraction	41/1300	154/7206	0.00774623904205
ko00562	Inositol phosphate metabolism	26/1300	89/7206	0.00825695118591
ko05321	Inflammatory bowel disease (IBD)	3/1300	56/7206	0.00858575002511
ko05131	Shigellosis	6/1300	82/7206	0.00874444880387
ko04115	p53 signaling pathway	5/1300	74/7206	0.00902613724782
ko00630	Glyoxylate and dicarboxylate metabolism	1/1300	38/7206	0.00944802583534
ko04658	Th1 and Th2 cell differentiation	8/1300	96/7206	0.0106203389057
ko04657	IL-17 signaling pathway	7/1300	87/7206	0.0113360900177
ko05418	Fluid shear stress and atherosclerosis	19/1300	173/7206	0.0122702896643
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1300	100/7206	0.0124861623355
ko04350	TGF-beta signaling pathway	9/1300	103/7206	0.0134034886447
ko04973	Carbohydrate digestion and absorption	14/1300	42/7206	0.014868934887
ko04916	Melanogenesis	37/1300	142/7206	0.0151441494184
ko01524	Platinum drug resistance	6/1300	76/7206	0.01641181051
ko05217	Basal cell carcinoma	5/1300	68/7206	0.0172074550905
ko04620	Toll-like receptor signaling pathway	9/1300	100/7206	0.0175914021498
ko00590	Arachidonic acid metabolism	3/1300	52/7206	0.0175962459759
ko00330	Arginine and proline metabolism	4/1300	61/7206	0.0179109443467
ko04930	Type II diabetes mellitus	17/1300	54/7206	0.018965851545
ko04015	Rap1 signaling pathway	65/1300	278/7206	0.0209660104254
ko04668	TNF signaling pathway	12/1300	120/7206	0.0221180064085
ko05132	Salmonella infection	9/1300	98/7206	0.0234809561178
ko04210	Apoptosis	21/1300	180/7206	0.0236520792722
ko05222	Small cell lung cancer	8/1300	89/7206	0.0255304923323
ko04710	Circadian rhythm	14/1300	43/7206	0.0258305754609
ko05214	Glioma	22/1300	79/7206	0.0272677613429
ko04217	Necroptosis	21/1300	178/7206	0.0294121895969
ko04062	Chemokine signaling pathway	48/1300	201/7206	0.0323393529644
ko00600	Sphingolipid metabolism	5/1300	63/7206	0.0325345867116
ko04640	Hematopoietic cell lineage	5/1300	64/7206	0.0326290507237
ko03410	Base excision repair	2/1300	38/7206	0.0349410505553
ko00260	Glycine, serine and threonine metabolism	3/1300	48/7206	0.0360410219713
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1300	40/7206	0.0361176315923
ko04960	Aldosterone-regulated sodium reabsorption	13/1300	41/7206	0.0382655799849
ko03320	PPAR signaling pathway	6/1300	69/7206	0.0407739443613
ko04113	Meiosis - yeast	6/1300	70/7206	0.0410158842367
ko05212	Pancreatic cancer	8/1300	83/7206	0.0443508444021
ko04330	Notch signaling pathway	5/1300	62/7206	0.0448214969719
ko04213	Longevity regulating pathway - multiple species	23/1300	86/7206	0.0467623629098
ko00280	Valine, leucine and isoleucine degradation	4/1300	54/7206	0.0484386742779
ko05320	Autoimmune thyroid disease	1/1300	29/7206	0.0485356657894