ko pathway ratio_in_study ratio_in_pop p_value ko04713 Circadian entrainment 36/428 136/7206 7.46956043492e-15 ko04724 Glutamatergic synapse 35/428 152/7206 1.60209478055e-12 ko04728 Dopaminergic synapse 36/428 185/7206 1.37526360462e-10 ko04745 Phototransduction - fly 14/428 38/7206 1.43019700962e-08 ko04911 Insulin secretion 24/428 117/7206 6.29524082983e-08 ko04970 Salivary secretion 20/428 95/7206 5.18156020644e-07 ko05033 Nicotine addiction 15/428 56/7206 5.40164153489e-07 ko04721 Synaptic vesicle cycle 18/428 80/7206 6.85801413737e-07 ko04720 Long-term potentiation 20/428 99/7206 1.03988332838e-06 ko05031 Amphetamine addiction 19/428 91/7206 1.1441422901e-06 ko04727 GABAergic synapse 21/428 110/7206 1.48486463607e-06 ko04971 Gastric acid secretion 19/428 98/7206 3.70566184898e-06 ko04514 Cell adhesion molecules (CAMs) 22/428 130/7206 6.74334914923e-06 ko04020 Calcium signaling pathway 35/428 265/7206 6.90434179913e-06 ko04725 Cholinergic synapse 25/428 160/7206 7.00775271938e-06 ko04024 cAMP signaling pathway 36/428 279/7206 7.67229394618e-06 ko04261 Adrenergic signaling in cardiomyocytes 29/428 205/7206 1.27181058017e-05 ko04744 Phototransduction 10/428 36/7206 3.08797168952e-05 ko04740 Olfactory transduction 15/428 80/7206 5.90010925505e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 14/428 74/7206 9.36860242464e-05 ko04925 Aldosterone synthesis and secretion 17/428 105/7206 0.000132769067687 ko04730 Long-term depression 14/428 78/7206 0.000169078278677 ko04964 Proximal tubule bicarbonate reclamation 8/428 29/7206 0.000205609044868 ko05032 Morphine addiction 17/428 110/7206 0.000237533586554 ko04723 Retrograde endocannabinoid signaling 23/428 175/7206 0.000272277388579 ko04921 Oxytocin signaling pathway 26/428 209/7206 0.000282995468574 ko04626 Plant-pathogen interaction 6/428 18/7206 0.000426294943561 ko04922 Glucagon signaling pathway 18/428 128/7206 0.00051803958093 ko04022 cGMP-PKG signaling pathway 26/428 216/7206 0.000587510201333 ko04360 Axon guidance 27/428 233/7206 0.000955168555733 ko05203 Viral carcinogenesis 5/428 277/7206 0.00109740438619 ko05322 Systemic lupus erythematosus 1/428 151/7206 0.0015097294516 ko04924 Renin secretion 13/428 86/7206 0.00155482442644 ko05168 Herpes simplex infection 2/428 182/7206 0.00211149482953 ko03040 Spliceosome 1/428 145/7206 0.00220586325984 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/428 59/7206 0.00223560754825 ko05010 Alzheimer's disease 23/428 202/7206 0.00225371382992 ko04080 Neuroactive ligand-receptor interaction 40/428 423/7206 0.00285579580619 ko04120 Ubiquitin mediated proteolysis 1/428 138/7206 0.00321994351096 ko04966 Collecting duct acid secretion 6/428 26/7206 0.00352504431795 ko05030 Cocaine addiction 11/428 73/7206 0.0035902903006 ko05110 Vibrio cholerae infection 10/428 63/7206 0.00367912841683 ko04060 Cytokine-cytokine receptor interaction 3/428 191/7206 0.00488450104827 ko04972 Pancreatic secretion 14/428 111/7206 0.00685197725108 ko04070 Phosphatidylinositol signaling system 14/428 112/7206 0.00726811391263 ko04960 Aldosterone-regulated sodium reabsorption 7/428 41/7206 0.00962129474659 ko04973 Carbohydrate digestion and absorption 7/428 42/7206 0.0109725912161 ko04014 Ras signaling pathway 27/428 279/7206 0.0131639242124 ko05161 Hepatitis B 3/428 173/7206 0.0134225101109 ko05166 HTLV-I infection 8/428 292/7206 0.0156109133851 ko04550 Signaling pathways regulating pluripotency of stem cells 3/428 165/7206 0.0184890542376 ko03013 RNA transport 3/428 166/7206 0.0186049374732 ko05164 Influenza A 3/428 167/7206 0.0187664403618 ko04015 Rap1 signaling pathway 26/428 278/7206 0.0192358023651 ko04371 Apelin signaling pathway 18/428 177/7206 0.0229432335095 ko04630 Jak-STAT signaling pathway 2/428 132/7206 0.0242524421896 ko04270 Vascular smooth muscle contraction 16/428 154/7206 0.0244716217038 ko04726 Serotonergic synapse 15/428 137/7206 0.0256989447078 ko04976 Bile secretion 10/428 80/7206 0.0266280743715 ko04114 Oocyte meiosis 15/428 139/7206 0.0267607266839 ko04978 Mineral absorption 6/428 40/7206 0.0292069710932 ko05205 Proteoglycans in cancer 8/428 271/7206 0.0348260746416 ko04940 Type I diabetes mellitus 5/428 32/7206 0.0385781174111 ko04152 AMPK signaling pathway 16/428 161/7206 0.0407501810782 ko04260 Cardiac muscle contraction 11/428 98/7206 0.0474165007401 ko05162 Measles 2/428 120/7206 0.0483235967595