ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	212/1316	423/7206	1.02479575406e-53
ko04724	Glutamatergic synapse	94/1316	152/7206	2.35995436719e-33
ko05033	Nicotine addiction	50/1316	56/7206	5.72355004534e-31
ko04713	Circadian entrainment	81/1316	136/7206	3.0721586889e-27
ko05032	Morphine addiction	71/1316	110/7206	4.39662742101e-27
ko04727	GABAergic synapse	70/1316	110/7206	3.68414964604e-26
ko04721	Synaptic vesicle cycle	54/1316	80/7206	2.93575652116e-22
ko04728	Dopaminergic synapse	87/1316	185/7206	1.06152679477e-19
ko04020	Calcium signaling pathway	110/1316	265/7206	3.1227593746e-19
ko04725	Cholinergic synapse	78/1316	160/7206	6.10541905246e-19
ko04024	cAMP signaling pathway	112/1316	279/7206	3.38605634982e-18
ko04911	Insulin secretion	61/1316	117/7206	7.39799230225e-17
ko04723	Retrograde endocannabinoid signaling	79/1316	175/7206	1.08511552962e-16
ko04742	Taste transduction	40/1316	61/7206	3.93268651863e-16
ko04726	Serotonergic synapse	65/1316	137/7206	3.05756659274e-15
ko04744	Phototransduction	28/1316	36/7206	1.09924764529e-14
ko04921	Oxytocin signaling pathway	85/1316	209/7206	1.93264282362e-14
ko05031	Amphetamine addiction	45/1316	91/7206	1.00045294226e-11
ko04970	Salivary secretion	46/1316	95/7206	1.50585641125e-11
ko04720	Long-term potentiation	47/1316	99/7206	2.18580401759e-11
ko04261	Adrenergic signaling in cardiomyocytes	77/1316	205/7206	4.01892501464e-11
ko04740	Olfactory transduction	40/1316	80/7206	9.26055282602e-11
ko03040	Spliceosome	2/1316	145/7206	1.35539378323e-10
ko04022	cGMP-PKG signaling pathway	77/1316	216/7206	8.73746616436e-10
ko04360	Axon guidance	79/1316	233/7206	6.85222578603e-09
ko05203	Viral carcinogenesis	19/1316	277/7206	4.66334494878e-08
ko04925	Aldosterone synthesis and secretion	43/1316	105/7206	5.48816209587e-08
ko03013	RNA transport	7/1316	166/7206	7.24027665944e-08
ko05030	Cocaine addiction	33/1316	73/7206	9.56937441353e-08
ko05168	Herpes simplex infection	10/1316	182/7206	4.99588079785e-07
ko05322	Systemic lupus erythematosus	7/1316	151/7206	1.02744669899e-06
ko04971	Gastric acid secretion	38/1316	98/7206	1.91381533982e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1316	74/7206	2.10694950591e-06
ko04540	Gap junction	46/1316	128/7206	2.26576023068e-06
ko04730	Long-term depression	32/1316	78/7206	2.26983766453e-06
ko04060	Cytokine-cytokine receptor interaction	12/1316	191/7206	2.34735890123e-06
ko04924	Renin secretion	34/1316	86/7206	3.35508235713e-06
ko04966	Collecting duct acid secretion	15/1316	26/7206	7.91719844294e-06
ko04972	Pancreatic secretion	39/1316	111/7206	1.84734530585e-05
ko04010	MAPK signaling pathway	89/1316	321/7206	2.21427726954e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1316	79/7206	2.85666831255e-05
ko04120	Ubiquitin mediated proteolysis	8/1316	138/7206	2.94735412744e-05
ko04745	Phototransduction - fly	18/1316	38/7206	3.73048000064e-05
ko04141	Protein processing in endoplasmic reticulum	14/1316	184/7206	4.32721816979e-05
ko04110	Cell cycle	9/1316	145/7206	4.52806692271e-05
ko04514	Cell adhesion molecules (CAMs)	43/1316	130/7206	4.57657584149e-05
ko04976	Bile secretion	30/1316	80/7206	5.21610388634e-05
ko05110	Vibrio cholerae infection	25/1316	63/7206	5.64418819676e-05
ko04070	Phosphatidylinositol signaling system	38/1316	112/7206	6.13025611045e-05
ko04621	NOD-like receptor signaling pathway	11/1316	157/7206	6.28454497531e-05
ko05140	Leishmaniasis	2/1316	75/7206	6.43793236954e-05
ko04064	NF-kappa B signaling pathway	4/1316	96/7206	8.08256711652e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1316	79/7206	9.54056288225e-05
ko04260	Cardiac muscle contraction	34/1316	98/7206	9.80272188173e-05
ko04750	Inflammatory mediator regulation of TRP channels	40/1316	122/7206	0.000120633142363
ko04371	Apelin signaling pathway	53/1316	177/7206	0.000154787056753
ko05164	Influenza A	13/1316	167/7206	0.000155036393081
ko05414	Dilated cardiomyopathy	37/1316	112/7206	0.000169519731057
ko04014	Ras signaling pathway	76/1316	279/7206	0.000185255135315
ko04072	Phospholipase D signaling pathway	57/1316	197/7206	0.000233727770876
ko05169	Epstein-Barr virus infection	19/1316	206/7206	0.000332414708852
ko04923	Regulation of lipolysis in adipocytes	27/1316	77/7206	0.000485981534684
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1316	59/7206	0.00051596689694
ko04146	Peroxisome	5/1316	89/7206	0.000798094621598
ko04710	Circadian rhythm	17/1316	43/7206	0.00103644742673
ko04610	Complement and coagulation cascades	4/1316	79/7206	0.00105920116141
ko05162	Measles	9/1316	120/7206	0.00116509214255
ko05205	Proteoglycans in cancer	30/1316	271/7206	0.00128969393599
ko04612	Antigen processing and presentation	4/1316	77/7206	0.00154036771259
ko05410	Hypertrophic cardiomyopathy (HCM)	31/1316	100/7206	0.00166389640989
ko03420	Nucleotide excision repair	1/1316	46/7206	0.00174383531318
ko00310	Lysine degradation	4/1316	73/7206	0.00216325685879
ko05131	Shigellosis	5/1316	82/7206	0.00228278327325
ko00480	Glutathione metabolism	2/1316	55/7206	0.00239632301356
ko03022	Basal transcription factors	1/1316	44/7206	0.00266342056381
ko05161	Hepatitis B	17/1316	173/7206	0.00266463722827
ko04915	Estrogen signaling pathway	38/1316	131/7206	0.00274256828902
ko05144	Malaria	1/1316	45/7206	0.0028150282822
ko00071	Fatty acid degradation	1/1316	45/7206	0.0028150282822
ko04964	Proximal tubule bicarbonate reclamation	12/1316	29/7206	0.00315338682587
ko04922	Glucagon signaling pathway	37/1316	128/7206	0.00359090991414
ko04930	Type II diabetes mellitus	19/1316	54/7206	0.00380211302445
ko00240	Pyrimidine metabolism	9/1316	110/7206	0.00399583602224
ko05166	HTLV-I infection	35/1316	292/7206	0.00409616214318
ko04330	Notch signaling pathway	3/1316	62/7206	0.00425562547852
ko04622	RIG-I-like receptor signaling pathway	3/1316	62/7206	0.00425562547852
ko04657	IL-17 signaling pathway	6/1316	87/7206	0.00468175507112
ko05133	Pertussis	6/1316	87/7206	0.00468175507112
ko00562	Inositol phosphate metabolism	27/1316	89/7206	0.00529716527512
ko03018	RNA degradation	6/1316	84/7206	0.00634850504947
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1316	14/7206	0.00690653084995
ko05321	Inflammatory bowel disease (IBD)	3/1316	56/7206	0.00849486034594
ko04640	Hematopoietic cell lineage	4/1316	64/7206	0.00884440166552
ko04626	Plant-pathogen interaction	8/1316	18/7206	0.00933781001723
ko00630	Glyoxylate and dicarboxylate metabolism	1/1316	38/7206	0.00959609437343
ko05145	Toxoplasmosis	12/1316	126/7206	0.00995616049221
ko04658	Th1 and Th2 cell differentiation	8/1316	96/7206	0.0107556650174
ko04270	Vascular smooth muscle contraction	41/1316	154/7206	0.0109218201266
ko00860	Porphyrin and chlorophyll metabolism	1/1316	34/7206	0.0138021000356
ko05217	Basal cell carcinoma	5/1316	68/7206	0.0171185417051
ko05132	Salmonella infection	9/1316	98/7206	0.0172837881699
ko00590	Arachidonic acid metabolism	3/1316	52/7206	0.0176700676712
ko04210	Apoptosis	21/1316	180/7206	0.0188468929757
ko04711	Circadian rhythm - fly	6/1316	13/7206	0.0195457637263
ko04015	Rap1 signaling pathway	66/1316	278/7206	0.021345197065
ko04115	p53 signaling pathway	6/1316	74/7206	0.022269328612
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1316	40/7206	0.0238683888881
ko04213	Longevity regulating pathway - multiple species	24/1316	86/7206	0.024447439279
ko04142	Lysosome	17/1316	151/7206	0.0248486791014
ko04214	Apoptosis - fly	6/1316	72/7206	0.0304352121977
ko04932	Non-alcoholic fatty liver disease (NAFLD)	22/1316	182/7206	0.0319378847688
ko00280	Valine, leucine and isoleucine degradation	4/1316	54/7206	0.0341938426776
ko03410	Base excision repair	2/1316	38/7206	0.0346065807748
ko04620	Toll-like receptor signaling pathway	10/1316	100/7206	0.0358459316422
ko05219	Bladder cancer	3/1316	48/7206	0.0365655329822
ko01524	Platinum drug resistance	7/1316	76/7206	0.0369484486948
ko04217	Necroptosis	22/1316	178/7206	0.0389518475476
ko04960	Aldosterone-regulated sodium reabsorption	13/1316	41/7206	0.0394871496712
ko04630	Jak-STAT signaling pathway	15/1316	132/7206	0.0401277703449
ko03320	PPAR signaling pathway	6/1316	69/7206	0.0406763060449
ko05231	Choline metabolism in cancer	34/1316	134/7206	0.0412916734745
ko04113	Meiosis - yeast	6/1316	70/7206	0.041474666753
ko05230	Central carbon metabolism in cancer	22/1316	81/7206	0.0427461283892
ko04973	Carbohydrate digestion and absorption	13/1316	42/7206	0.0432640482446
ko01212	Fatty acid metabolism	5/1316	60/7206	0.0440759061896
ko00330	Arginine and proline metabolism	5/1316	61/7206	0.0443530989781
ko04912	GnRH signaling pathway	31/1316	122/7206	0.0443639383511
ko05215	Prostate cancer	12/1316	111/7206	0.0465186471049
ko04918	Thyroid hormone synthesis	23/1316	86/7206	0.0485459298057
ko05320	Autoimmune thyroid disease	1/1316	29/7206	0.0491830186493