ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 73/579 423/7206 1.39399378539e-10 ko05032 Morphine addiction 31/579 110/7206 2.62767559076e-10 ko04724 Glutamatergic synapse 36/579 152/7206 1.90683421347e-09 ko04725 Cholinergic synapse 36/579 160/7206 8.33564442385e-09 ko04727 GABAergic synapse 27/579 110/7206 9.49900089808e-08 ko04726 Serotonergic synapse 30/579 137/7206 2.82206140527e-07 ko04020 Calcium signaling pathway 46/579 265/7206 4.03392026165e-07 ko04921 Oxytocin signaling pathway 39/579 209/7206 4.49352235812e-07 ko04713 Circadian entrainment 29/579 136/7206 8.05345159992e-07 ko04024 cAMP signaling pathway 46/579 279/7206 2.48788632551e-06 ko04728 Dopaminergic synapse 34/579 185/7206 3.5744635063e-06 ko05033 Nicotine addiction 16/579 56/7206 4.90563282552e-06 ko04723 Retrograde endocannabinoid signaling 32/579 175/7206 7.78466885994e-06 ko04710 Circadian rhythm 13/579 43/7206 1.94946092709e-05 ko04070 Phosphatidylinositol signaling system 23/579 112/7206 2.13284636108e-05 ko04911 Insulin secretion 23/579 117/7206 4.43797845074e-05 ko04721 Synaptic vesicle cycle 18/579 80/7206 4.71760982032e-05 ko03040 Spliceosome 1/579 145/7206 0.00014018571007 ko04072 Phospholipase D signaling pathway 32/579 197/7206 0.00014451656805 ko03010 Ribosome 1/579 129/7206 0.000439611691426 ko05203 Viral carcinogenesis 8/579 277/7206 0.00062093583654 ko04720 Long-term potentiation 18/579 99/7206 0.00102615134347 ko03013 RNA transport 3/579 166/7206 0.00120534448576 ko05031 Amphetamine addiction 17/579 91/7206 0.00126283429 ko04360 Axon guidance 33/579 233/7206 0.00126587363569 ko04744 Phototransduction 9/579 36/7206 0.0017185236746 ko04750 Inflammatory mediator regulation of TRP channels 20/579 122/7206 0.0019861749691 ko00010 Glycolysis / Gluconeogenesis 14/579 74/7206 0.00199223368968 ko04970 Salivary secretion 16/579 95/7206 0.00375882080018 ko04922 Glucagon signaling pathway 20/579 128/7206 0.00439595399396 ko00680 Methane metabolism 8/579 34/7206 0.00461046521437 ko04514 Cell adhesion molecules (CAMs) 20/579 130/7206 0.00477247228297 ko00562 Inositol phosphate metabolism 15/579 89/7206 0.00505269036096 ko04014 Ras signaling pathway 35/579 279/7206 0.00689885665128 ko04022 cGMP-PKG signaling pathway 29/579 216/7206 0.00699086469377 ko04742 Taste transduction 11/579 61/7206 0.00848492309234 ko04745 Phototransduction - fly 8/579 38/7206 0.0093467777223 ko04925 Aldosterone synthesis and secretion 16/579 105/7206 0.0106744823973 ko04141 Protein processing in endoplasmic reticulum 6/579 184/7206 0.0126596730123 ko04110 Cell cycle 4/579 145/7206 0.0129855897869 ko04971 Gastric acid secretion 15/579 98/7206 0.0135247916928 ko04010 MAPK signaling pathway 38/579 321/7206 0.0151384733256 ko04711 Circadian rhythm - fly 4/579 13/7206 0.0164108806386 ko04610 Complement and coagulation cascades 1/579 79/7206 0.0199416361326 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/579 14/7206 0.0215460910303 ko04923 Regulation of lipolysis in adipocytes 12/579 77/7206 0.0309437638469 ko03015 mRNA surveillance pathway 2/579 93/7206 0.032643678229 ko00471 D-Glutamine and D-glutamate metabolism 2/579 4/7206 0.0346685807392 ko05230 Central carbon metabolism in cancer 12/579 81/7206 0.0362655476668 ko05168 Herpes simplex infection 7/579 182/7206 0.0368638046272 ko04930 Type II diabetes mellitus 9/579 54/7206 0.0373933203803 ko00030 Pentose phosphate pathway 6/579 32/7206 0.0393875935581 ko04972 Pancreatic secretion 15/579 111/7206 0.0495978887694