ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 34/521 191/7206 6.5767626844e-07 ko04512 ECM-receptor interaction 17/521 79/7206 3.66784334953e-05 ko04710 Circadian rhythm 11/521 43/7206 0.000173786359574 ko05322 Systemic lupus erythematosus 1/521 151/7206 0.000328010808768 ko04510 Focal adhesion 32/521 240/7206 0.000817123813672 ko05203 Viral carcinogenesis 7/521 277/7206 0.000830748048294 ko04020 Calcium signaling pathway 34/521 265/7206 0.00095923809346 ko04022 cGMP-PKG signaling pathway 29/521 216/7206 0.00114781861043 ko00643 Styrene degradation 3/521 4/7206 0.00142261390772 ko03010 Ribosome 1/521 129/7206 0.00152614661783 ko00350 Tyrosine metabolism 8/521 33/7206 0.00195151158584 ko04921 Oxytocin signaling pathway 27/521 209/7206 0.00266955120681 ko03040 Spliceosome 2/521 145/7206 0.00294091578648 ko03013 RNA transport 3/521 166/7206 0.00342501202648 ko00590 Arachidonic acid metabolism 10/521 52/7206 0.00356606263689 ko04925 Aldosterone synthesis and secretion 16/521 105/7206 0.00371916039165 ko04120 Ubiquitin mediated proteolysis 2/521 138/7206 0.00411366866238 ko04270 Vascular smooth muscle contraction 21/521 154/7206 0.00416708614585 ko05146 Amoebiasis 15/521 99/7206 0.00526517221499 ko04640 Hematopoietic cell lineage 11/521 64/7206 0.0056418916619 ko04070 Phosphatidylinositol signaling system 16/521 112/7206 0.00846383093887 ko04014 Ras signaling pathway 32/521 279/7206 0.00894464762564 ko04110 Cell cycle 3/521 145/7206 0.00921895287831 ko04974 Protein digestion and absorption 14/521 96/7206 0.00941129850553 ko04933 AGE-RAGE signaling pathway in diabetic complications 18/521 135/7206 0.0106570134327 ko04711 Circadian rhythm - fly 4/521 13/7206 0.0114141202497 ko00120 Primary bile acid biosynthesis 5/521 20/7206 0.0120926903284 ko04610 Complement and coagulation cascades 12/521 79/7206 0.0132468033279 ko03015 mRNA surveillance pathway 1/521 93/7206 0.0139982370848 ko04810 Regulation of actin cytoskeleton 30/521 264/7206 0.0146105793633 ko05230 Central carbon metabolism in cancer 12/521 81/7206 0.015143769414 ko05034 Alcoholism 8/521 238/7206 0.0151955995956 ko04151 PI3K-Akt signaling pathway 41/521 390/7206 0.015278838614 ko04745 Phototransduction - fly 7/521 38/7206 0.0175634631923 ko04072 Phospholipase D signaling pathway 23/521 197/7206 0.0241378753839 ko00140 Steroid hormone biosynthesis 7/521 41/7206 0.0259737458069 ko04960 Aldosterone-regulated sodium reabsorption 7/521 41/7206 0.0259737458069 ko05169 Epstein-Barr virus infection 7/521 206/7206 0.028260770111 ko00051 Fructose and mannose metabolism 7/521 42/7206 0.029298885602 ko04725 Cholinergic synapse 19/521 160/7206 0.0294316833926 ko00710 Carbon fixation in photosynthetic organisms 5/521 27/7206 0.041550369552 ko04380 Osteoclast differentiation 16/521 134/7206 0.0419731750787 ko05130 Pathogenic Escherichia coli infection 1/521 77/7206 0.0429533937081 ko04713 Circadian entrainment 16/521 136/7206 0.0449015370793 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/521 5/7206 0.0450602188499 ko04672 Intestinal immune network for IgA production 6/521 37/7206 0.0474787516817 ko04919 Thyroid hormone signaling pathway 17/521 143/7206 0.0475485988857