ko pathway ratio_in_study ratio_in_pop p_value ko03030 DNA replication 28/376 38/7206 1.35305510908e-28 ko04110 Cell cycle 44/376 145/7206 8.91068598065e-23 ko04111 Cell cycle - yeast 35/376 90/7206 2.28701850489e-22 ko03040 Spliceosome 42/376 145/7206 6.59195370403e-21 ko03430 Mismatch repair 15/376 22/7206 5.38491973413e-15 ko04113 Meiosis - yeast 24/376 70/7206 3.10514222839e-14 ko03410 Base excision repair 16/376 38/7206 1.70903744801e-11 ko03013 RNA transport 31/376 166/7206 3.27845242666e-10 ko03420 Nucleotide excision repair 16/376 46/7206 5.18118944672e-10 ko03460 Fanconi anemia pathway 15/376 51/7206 2.493476315e-08 ko03440 Homologous recombination 13/376 41/7206 8.02604600357e-08 ko00240 Pyrimidine metabolism 21/376 110/7206 1.7345908151e-07 ko03015 mRNA surveillance pathway 19/376 93/7206 2.22541880417e-07 ko04144 Endocytosis 1/376 342/7206 2.77558861567e-07 ko03008 Ribosome biogenesis in eukaryotes 13/376 79/7206 0.000196872806107 ko00230 Purine metabolism 23/376 194/7206 0.000203125660127 ko04120 Ubiquitin mediated proteolysis 18/376 138/7206 0.000275353634487 ko05166 HTLV-I infection 30/376 292/7206 0.000369214860271 ko04062 Chemokine signaling pathway 1/376 201/7206 0.000521755602803 ko04060 Cytokine-cytokine receptor interaction 1/376 191/7206 0.000735959825605 ko04218 Cellular senescence 20/376 177/7206 0.00092922828915 ko04022 cGMP-PKG signaling pathway 2/376 216/7206 0.00152536953605 ko04723 Retrograde endocannabinoid signaling 1/376 175/7206 0.00156375465675 ko03050 Proteasome 9/376 54/7206 0.00171384944687 ko04921 Oxytocin signaling pathway 2/376 209/7206 0.00220941274579 ko04114 Oocyte meiosis 16/376 139/7206 0.00283217440716 ko04621 NOD-like receptor signaling pathway 1/376 157/7206 0.00329314229331 ko04725 Cholinergic synapse 1/376 160/7206 0.00333818662498 ko04270 Vascular smooth muscle contraction 1/376 154/7206 0.00495507326918 ko05012 Parkinson's disease 1/376 155/7206 0.00503372952916 ko04024 cAMP signaling pathway 5/376 279/7206 0.00552460754564 ko04612 Antigen processing and presentation 10/376 77/7206 0.00637164636615 ko05217 Basal cell carcinoma 9/376 68/7206 0.00836260925054 ko04371 Apelin signaling pathway 2/376 177/7206 0.00897874584525 ko04340 Hedgehog signaling pathway 8/376 58/7206 0.00990409817447 ko04713 Circadian entrainment 1/376 136/7206 0.0101740251737 ko03010 Ribosome 1/376 129/7206 0.0148057826108 ko04514 Cell adhesion molecules (CAMs) 1/376 130/7206 0.0149405493981 ko04915 Estrogen signaling pathway 1/376 131/7206 0.0151183389531 ko00670 One carbon pool by folate 4/376 20/7206 0.0181720609918 ko04810 Regulation of actin cytoskeleton 6/376 264/7206 0.0236093347133 ko04972 Pancreatic secretion 1/376 111/7206 0.030570036965 ko04550 Signaling pathways regulating pluripotency of stem cells 15/376 165/7206 0.0319870664723 ko04911 Insulin secretion 1/376 117/7206 0.0321243066806 ko04910 Insulin signaling pathway 3/376 172/7206 0.0356030614354 ko05169 Epstein-Barr virus infection 18/376 206/7206 0.0363624775672 ko05206 MicroRNAs in cancer 16/376 177/7206 0.0371441667867 ko04014 Ras signaling pathway 7/376 279/7206 0.0381938906966 ko03450 Non-homologous end-joining 3/376 15/7206 0.0401650371858 ko04330 Notch signaling pathway 7/376 62/7206 0.0414708563789 ko04139 Mitophagy - yeast 5/376 37/7206 0.0415409259484 ko04925 Aldosterone synthesis and secretion 1/376 105/7206 0.0442234456507 ko04659 Th17 cell differentiation 1/376 106/7206 0.0445002562507 ko04012 ErbB signaling pathway 1/376 109/7206 0.0459924891879 ko04712 Circadian rhythm - plant 2/376 7/7206 0.0478971862304 ko04630 Jak-STAT signaling pathway 2/376 132/7206 0.048077988524 ko04933 AGE-RAGE signaling pathway in diabetic complications 2/376 135/7206 0.0484030618673 ko04071 Sphingolipid signaling pathway 3/376 162/7206 0.0484828815088 ko04611 Platelet activation 3/376 163/7206 0.0485802801844 ko04931 Insulin resistance 2/376 137/7206 0.0490811716104